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公开(公告)号：US10890720B2
公开(公告)日：2021-01-12
申请号：US16179609
申请日：2018-11-02
Applicant: GEN-PROBE INCORPORATED
Inventor： Norbert D. Hagen , David Opalsky
Abstract: A method of measuring a time-varying signal emission, the method including subjecting the contents of a receptacle to a thermal cycling process. During the thermal cycling process, measuring a signal emission from the contents of the receptacle at regular time intervals and recording the measured signal emission and a time stamp at each time interval. Also during the thermal cycling process, determining a temperature of the thermal cycling process at regular time intervals and recording the determined temperature and a time stamp at each time interval. The measured signal emissions are synchronized with a specific temperature of the thermal cycling process by comparing the time stamps of the measured emission signals with the time stamps of the determined temperatures.
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公开(公告)号：US10829810B2
公开(公告)日：2020-11-10
申请号：US15720467
申请日：2017-09-29
Applicant: GEN-PROBE INCORPORATED
Inventor： Byron J. Knight , David Opalsky
Abstract: The disclosure provides solid compositions such as lyophilisates adhered to surfaces such as plasma-treated surfaces and related methods, uses, kits, intermediates, starting materials, and downstream products.
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公开(公告)号：US09810622B2
公开(公告)日：2017-11-07
申请号：US15094227
申请日：2016-04-08
Applicant: GEN-PROBE INCORPORATED
Inventor： Norbert D. Hagen , Byron J. Knight , David Opalsky
CPC classification number: G01N21/15 , B08B1/00 , B08B9/00 , B08B2240/02 , G01N35/00623 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2021/152 , G01N2035/00277 , G02B6/3866
Abstract: A sample testing system includes a test receptacle support structure, an optical element positioned for transmitting electromagnetic radiation emitted or reflected by a sample disposed in a test receptacle supported by the test receptacle support structure, a cleaning member, and an automated transport arm configured to (i) detachably couple the cleaning member, (ii) move the detachably-coupled cleaning member into a position proximate to and/or contacting the optical element, and (iii) decouple the cleaning member.
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公开(公告)号：US09588069B2
公开(公告)日：2017-03-07
申请号：US13956060
申请日：2013-07-31
Applicant: Gen-Probe Incorporated
Inventor： David Opalsky , Norbert D. Hagen , Rolf Silbert , Sean Siyao Chiu , Haitao Li
CPC classification number: G01N25/04 , B01L7/5255 , B01L9/06 , B01L2200/028 , B01L2300/0627 , B01L2300/1827 , G01N21/6428 , G01N2021/6432 , G01N2021/6439
Abstract: The present disclosure provides apparatus, systems, and methods for conducting rapid, accurate, and consistent heated amplifications and/or thermal melt analyses.
Abstract translation: 本公开提供用于进行快速，准确和一致的加热放大和/或热熔融分析的装置，系统和方法。
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公开(公告)号：US12110535B2
公开(公告)日：2024-10-08
申请号：US18385300
申请日：2023-10-30
Applicant: Gen-Probe Incorporated
Inventor： David A. Buse , Norbert D. Hagen , David Opalsky
IPC: C12Q1/6806 , B01L3/00 , B01L7/00 , C12Q1/686 , G01N35/04
CPC classification number: C12Q1/6806 , B01L3/50825 , B01L3/565 , B01L7/5255 , C12Q1/686 , G01N35/04 , B01L3/527 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , G01N2035/0418 , G01N2035/0436
Abstract: A method for reconstituting a reagent within a reagent pack including one or more wells and at least one of the wells containing a lyophilized reagent comprises the steps of receiving reagent packs into a reagent pack input carousel, transferring one reagent pack with a rotary distributor from the input carousel to a reagent pack storage carousel, retrieving the reagent pack from the storage carousel with the rotary distributor and placing the reagent pack into a reagent pack loading station, and dispensing a reconstitution reagent with an automated pipettor into the well containing the lyophilized reagent to form a reconstituted reagent.
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Patent Agency Ranking
36.发明公开公开(公告)号：US20240150822A1
公开(公告)日：2024-05-09
申请号：US18386976
申请日：2023-11-03
Applicant: Gen-Probe Incorporated
Inventor： David BUSE , David Howard Combs , Norbert D. Hagen , David Opalsky , Bruce Richardson , Anita Frasad , Keith Moravick , Tyler Moore
CPC classification number: C12Q1/686 , B01L7/52 , G01N21/6452 , B01L9/06 , B01L2200/141 , B01L2200/142 , B01L2300/042 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/1822
Abstract: An apparatus comprises a thermally conductive receptacle holder including a plurality of receptacle wells configured to receive receptacles, a plurality of optical fibers having first and second ends, wherein each first end is in optical communication with one of the receptacle wells and each second end is in optical communication with an excitation signal source and/or an emission signal detector, one or more thermal elements positioned proximal to the receptacle holder for altering the temperature of the receptacle holder, a heat sink in thermal communication with the receptacle holder, and one or more thermal devices disposed within the heat sink for pre-heating the heat sink.
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公开(公告)号：US20240060114A1
公开(公告)日：2024-02-22
申请号：US18385300
申请日：2023-10-30
Applicant: Gen-Probe Incorporated
Inventor： David A. BUSE , Norbert D. Hagen , David Opalsky
IPC: C12Q1/6806 , G01N35/04 , B01L3/00 , B01L7/00 , C12Q1/686
CPC classification number: C12Q1/6806 , G01N35/04 , B01L3/50825 , B01L3/565 , B01L7/5255 , C12Q1/686 , G01N2035/0418 , G01N2035/0436 , B01L3/527 , B01L2200/026 , B01L2200/0689 , B01L2300/046
Abstract: A method for reconstituting a reagent within a reagent pack including one or more wells and at least one of the wells containing a lyophilized reagent comprises the steps of receiving reagent packs into a reagent pack input carousel, transferring one reagent pack with a rotary distributor from the input carousel to a reagent pack storage carousel, retrieving the reagent pack from the storage carousel with the rotary distributor and placing the reagent pack into a reagent pack loading station, and dispensing a reconstitution reagent with an automated pipettor into the well containing the lyophilized reagent to form a reconstituted reagent.
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公开(公告)号：US11809947B2
公开(公告)日：2023-11-07
申请号：US17694436
申请日：2022-03-14
Applicant: GEN-PROBE INCORPORATED
Inventor： Norbert D. Hagen , David Opalsky , Rolf Silbert
CPC classification number: G06K7/10732 , G01N35/00732 , G01N35/026 , G06K7/10811 , G06K7/10861 , G06K7/1413 , G06K7/1417 , G06K7/1447 , G06K19/06028 , G06K19/06037 , G01N2035/00752 , G01N2035/00801 , G01N2035/00831 , G01N2035/00851 , G01N2035/0413 , G01N2035/0493
Abstract: Method and associated system for reading machine-readable labels on a plurality of sample receptacles held by a sample rack. In the method, a machine-readable label associated each of the plurality of sample receptacles is read with a first label reader when the rack is at a first location. The sample rack is then moved from the first location to a second location, where a rack identifier on the sample rack is sensed with a sensor separate from the first label reader. Finally, the rack identifier is associated with the machine-readable labels of the plurality of sample receptacles.
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公开(公告)号：US11726041B2
公开(公告)日：2023-08-15
申请号：US17840388
申请日：2022-06-14
Applicant: GEN-PROBE INCORPORATED
Inventor： David Opalsky , Srajan Raghuwanshi , James Bui
CPC classification number: G01N21/645 , G01N21/0332 , G01N21/276 , G01N21/75 , G01N35/025 , G01N35/00732 , G01N2021/6441 , G01N2035/00356 , G01N2035/0455 , G01N2035/0475 , G01N2035/0484 , G01N2201/0407 , G01N2201/0415 , G01N2201/12723
Abstract: A method for measuring optical signal detector performance that includes directing light emitted from an optical signal detector onto a first non-fluorescent surface portion in a first detection zone of the optical signal detector. A first characteristic of light detected by a first sensor of the first optical signal detector is measured while the first non-fluorescent surface portion is in the first detection zone of the optical signal detector. Light emitted from the optical signal detector is directed into a first void in the first detection zone of the optical signal detector. A second characteristic of light detected by the first sensor of the optical signal detector is measured while the first void is in the first detection zone of the optical signal detector. And an operational performance status of the optical signal detector is determined based on at least one of the first characteristic and the second characteristic.
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公开(公告)号：US11693190B2
公开(公告)日：2023-07-04
申请号：US17144880
申请日：2021-01-08
Applicant: Gen-Probe Incorporated
Inventor： Norbert D. Hagen , David Opalsky
CPC classification number: G02B6/3668 , G01N21/253 , G01N21/6452 , G02B6/06 , G02B6/08 , G02B6/3672 , G02B6/4214 , G02B6/4246 , G02B6/4269 , G01N2021/6484
Abstract: An apparatus for detecting an emission signal from each of a plurality of emission signal sources includes one or more excitation sources configured to generate an excitation light of an excitation wavelength and one or more associated emission detectors configured to detect light of an emission wavelength. A transmission fiber is associated with each of the emission signal sources. A carrier is configured to move the one or more excitation sources and the one or more emission detectors relative to the transmission fibers to sequentially place each emission detector and associated excitation source in an operative position with respect to each transmission fiber. Each transmission fiber transmits both the excitation light from the excitation source and the corresponding emission light to the associated emission detector.
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