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公开(公告)号：US10407472B2
公开(公告)日：2019-09-10
申请号：US15842062
申请日：2017-12-14
Applicant: Spogen Biotech Inc.
Inventor： Brian Thompson , Ashley Siegel
IPC: C07K14/32 , A01N37/44 , A61L2/18 , C09K8/62 , E21B43/16 , A23K20/147 , C12P21/02 , C12N1/20 , C12N3/00 , C12N15/62 , C12N15/75 , A01N63/02 , C02F3/34 , A23K10/18 , A61K39/00 , C02F103/00 , C02F103/06 , C02F103/10 , C02F103/14 , C02F103/16 , C02F103/26 , C02F103/28 , C02F101/10 , C02F101/30
Abstract: Fusion proteins containing a targeting sequence, an exosporium protein, or an exosporium protein fragment that targets the fusion protein to the exosporium of a Bacillus cereus family member are provided. Recombinant Bacillus cereus family members expressing such fusion proteins are also provided. Genetically inactivated Bacillus cereus family members and recombinant Bacillus cereus family members that overexpress exosporium proteins are also provided. Seeds coated with the recombinant Bacillus cereus family members and methods for using the recombinant Bacillus cereus family members (e.g., for stimulating plant growth) are also provided. Various modifications of the recombinant Bacillus cereus family members that express the fusion proteins are further provided. Fusion proteins comprising a spore coat protein and a protein or peptide of interest, recombinant bacteria that express such fusion proteins, seeds coated with such recombinant bacteria, and methods for using such recombinant bacteria (e.g., for stimulating plant growth) are also provided.
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公开(公告)号：US10092009B2
公开(公告)日：2018-10-09
申请号：US15414050
申请日：2017-01-24
Applicant: Spogen Biotech Inc.
Inventor： Brian Thompson , Katie Thompson
Abstract: The present invention is generally directed to fusion proteins containing a targeting sequence that targets the fusion protein to the exosporium of a Bacillus cereus family member. The invention also relates to recombinant Bacillus cereus family members expressing such fusion proteins, formulations containing the recombinant Bacillus cereus family members expressing the fusion proteins. Methods for stimulating plant growth and for protecting plants from pathogens by applying the recombinant Bacillus cereus family members or the formulations to plants or a plant growth medium are also described. The invention also relates to methods for immobilizing spores of a recombinant Bacillus cereus family member expressing a fusion protein on plant roots.
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公开(公告)号：US20160262402A1
公开(公告)日：2016-09-15
申请号：US14775858
申请日：2014-03-17
Applicant: SPOGEN BIOTECH INC.
Inventor： Brian Thompson , Katie Thompson , Brittany Angle
CPC classification number: A01N63/00 , A01H3/00 , A01N63/02 , C12R1/01 , C12R1/05 , C12R1/07 , C12R1/075 , C12R1/085 , C12R1/125 , A01N25/00
Abstract: The present invention generally relates to bacteriologically pure bacterial cultures of novel strains of plant growth-promoting bacteria, and inoculums comprising the same. The invention is also directed to plant seeds coated with the inoculums, kits comprising the inoculums and methods for stimulating plant growth by applying the biologically pure bacterial culture or the inoculum to a plant, plant seed, or plant growth medium.
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34.发明申请FUSION PROTEINS, RECOMBINANT BACTERIA, AND METHODS FOR USING RECOMBINANT BACTERIA 有权融合蛋白，重组细菌和使用重组细菌的方法公开(公告)号：US20160108096A1
公开(公告)日：2016-04-21
申请号：US14857606
申请日：2015-09-17
Applicant: SPOGEN BIOTECH INC.
Inventor： Brian Thompson , Ashley Siegel
IPC: C07K14/32 , A23K1/16 , C12N9/18 , A01N63/00 , E21B43/16 , A61L2/18 , A23K1/00 , C09K8/62 , C02F3/34 , A61K39/07 , A01N37/44
CPC classification number: C07K14/32 , A01N37/44 , A01N63/02 , A23K10/18 , A23K20/147 , A61K39/00 , A61L2/18 , C02F3/342 , C02F3/348 , C02F2101/10 , C02F2101/30 , C02F2103/002 , C02F2103/003 , C02F2103/007 , C02F2103/06 , C02F2103/10 , C02F2103/14 , C02F2103/16 , C02F2103/26 , C02F2103/28 , C07K2319/01 , C07K2319/035 , C07K2319/40 , C09K8/62 , C09K2208/24 , C12N1/20 , C12N3/00 , C12N15/62 , C12N15/75 , C12P21/02 , E21B43/16
Abstract: Fusion proteins containing a targeting sequence, an exosporium protein, or an exosporium protein fragment that targets the fusion protein to the exosporium of a Bacillus cereus family member are provided. Recombinant Bacillus cereus family members expressing such fusion proteins are also provided. Genetically inactivated Bacillus cereus family members and recombinant Bacillus cereus family members that overexpress exosporium proteins are also provided. Seeds coated with the recombinant Bacillus cereus family members and methods for using the recombinant Bacillus cereus family members (e.g., for stimulating plant growth) are also provided. Various modifications of the recombinant Bacillus cereus family members that express the fusion proteins are further provided. Fusion proteins comprising a spore coat protein and a protein or peptide of interest, recombinant bacteria that express such fusion proteins, seeds coated with such recombinant bacteria, and methods for using such recombinant bacteria (e.g., for stimulating plant growth) are also provided.
Abstract translation: 提供了含有将融合蛋白靶向蜡状芽孢杆菌家族成员的外源的靶向序列，外切蛋白或外切蛋白片段的融合蛋白。 还提供了表达这种融合蛋白的重组蜡状芽孢杆菌家族成员。 还提供遗传灭活的蜡样芽孢杆菌家族成员和过表达外胚蛋白的重组蜡状芽孢杆菌家族成员。 还提供了用重组蜡状芽孢杆菌家族成员包被的种子和使用重组蜡状芽孢杆菌家族成员的方法（例如刺激植物生长）。 还提供了表达融合蛋白的重组蜡状芽孢杆菌家族成员的各种修饰。 还提供了包含孢子外壳蛋白和感兴趣的蛋白质或肽的融合蛋白，表达这种融合蛋白的重组细菌，用这种重组细菌包被的种子，以及使用这种重组细菌（例如刺激植物生长）的方法。
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公开(公告)号：US20240316173A1
公开(公告)日：2024-09-26
申请号：US18654255
申请日：2024-05-03
Applicant: Spogen Biotech Inc. , Bayer CropScience LP
Inventor： Damian Curtis , Brian Thompson
IPC: A61K39/07 , A61K35/00 , A61K35/742
CPC classification number: A61K39/07 , A61K35/742 , A61K2035/115
Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular fungicide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
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Patent Agency Ranking
公开(公告)号：US20240285745A1
公开(公告)日：2024-08-29
申请号：US18654243
申请日：2024-05-03
Applicant: Spogen Biotech Inc. , Bayer CropScience LP
Inventor： Damian Curtis , Brian Thompson
IPC: A61K39/07 , A61K35/00 , A61K35/742
CPC classification number: A61K39/07 , A61K35/742 , A61K2035/115
Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular fungicide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
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公开(公告)号：US20240285743A1
公开(公告)日：2024-08-29
申请号：US18644663
申请日：2024-04-24
Applicant: Spogen Biotech Inc. , Bayer CropScience LP
Inventor： Damian Curtis , Brian Thompson
IPC: A61K39/07 , A61K35/00 , A61K35/742
CPC classification number: A61K39/07 , A61K35/742 , C12Y301/01 , C12Y302/01004 , C12Y302/01132 , A61K2035/115 , Y02A50/30
Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
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公开(公告)号：US12016912B2
公开(公告)日：2024-06-25
申请号：US17356958
申请日：2021-06-24
Applicant: Bayer CropScience LP , Spogen Biotech Inc.
Inventor： Damian Curtis , Brian Thompson
IPC: A61K39/07 , A61K35/00 , A61K35/742
CPC classification number: A61K39/07 , A61K35/742 , C12Y301/01 , C12Y302/01004 , C12Y302/01132 , A61K2035/115 , Y02A50/30 , A01N63/50 , A01N63/22 , A01N63/50 , A01N43/22 , A01N43/56 , A01N43/90 , A01N47/22 , A01N47/40 , A01N53/00
Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
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公开(公告)号：US20240199709A1
公开(公告)日：2024-06-20
申请号：US18398650
申请日：2023-12-28
Applicant: Spogen Biotech Inc.
Inventor： Brian Thompson , Ashley Siegel
IPC: C07K14/32 , A01H3/00 , A01N37/44 , A01N63/10 , A01N63/20 , A01N63/50 , A23K10/18 , A23K20/147 , A61K39/00 , A61L2/18 , C02F3/34 , C02F101/10 , C02F101/30 , C02F103/00 , C02F103/06 , C02F103/10 , C02F103/14 , C02F103/16 , C02F103/26 , C02F103/28 , C09K8/62 , C12N1/20 , C12N3/00 , C12N15/62 , C12N15/75 , C12P21/02 , E21B43/16
CPC classification number: C07K14/32 , A01H3/00 , A01N37/44 , A01N63/10 , A01N63/50 , A23K20/147 , A61L2/18 , C02F3/342 , C02F3/348 , C09K8/62 , C12N1/20 , C12N3/00 , C12N15/62 , C12N15/75 , C12P21/02 , E21B43/16 , A01N63/20 , A23K10/18 , A61K39/00 , C02F2101/10 , C02F2101/30 , C02F2103/002 , C02F2103/003 , C02F2103/007 , C02F2103/06 , C02F2103/10 , C02F2103/14 , C02F2103/16 , C02F2103/26 , C02F2103/28 , C07K2319/01 , C07K2319/035 , C07K2319/40 , C09K2208/24
Abstract: Fusion proteins containing a targeting sequence, an exosporium protein, or an exosporium protein fragment that targets the fusion protein to the exosporium of a Bacillus cereus family member are provided. Recombinant Bacillus cereus family members expressing such fusion proteins are also provided. Genetically inactivated Bacillus cereus family members and recombinant Bacillus cereus family members that overexpress exosporium proteins are also provided. Seeds coated with the recombinant Bacillus cereus family members and methods for using the recombinant Bacillus cereus family members (e.g., for stimulating plant growth) are also provided. Various modifications of the recombinant Bacillus cereus family members that express the fusion proteins are further provided. Fusion proteins comprising a spore coat protein and a protein or peptide of interest, recombinant bacteria that express such fusion proteins, seeds coated with such recombinant bacteria, and methods for using such recombinant bacteria (e.g., for stimulating plant growth) are also provided.
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公开(公告)号：US11905315B2
公开(公告)日：2024-02-20
申请号：US17079942
申请日：2020-10-26
Applicant: Spogen Biotech Inc
Inventor： Brian Thompson , Ashley Siegel
IPC: C12N15/62 , A01H3/00 , A01N63/20 , C07K14/32 , A01N37/44 , A61L2/18 , C09K8/62 , E21B43/16 , C12P21/02 , C12N1/20 , C12N3/00 , C12N15/75 , C02F3/34 , A23K20/147 , A01N63/50 , A01N63/10 , A61K39/00 , C02F103/00 , C02F103/06 , C02F103/10 , C02F103/14 , C02F103/16 , C02F103/26 , C02F103/28 , A23K10/18 , C02F101/10 , C02F101/30
CPC classification number: C07K14/32 , A01H3/00 , A01N37/44 , A01N63/10 , A01N63/50 , A23K20/147 , A61L2/18 , C02F3/342 , C02F3/348 , C09K8/62 , C12N1/20 , C12N3/00 , C12N15/62 , C12N15/75 , C12P21/02 , E21B43/16 , A01N63/20 , A23K10/18 , A61K39/00 , C02F2101/10 , C02F2101/30 , C02F2103/002 , C02F2103/003 , C02F2103/007 , C02F2103/06 , C02F2103/10 , C02F2103/14 , C02F2103/16 , C02F2103/26 , C02F2103/28 , C07K2319/01 , C07K2319/035 , C07K2319/40 , C09K2208/24 , A01N63/50 , A01N63/22
Abstract: Fusion proteins containing a targeting sequence, an exosporium protein, or an exosporium protein fragment that targets the fusion protein to the exosporium of a Bacillus cereus family member are provided. Recombinant Bacillus cereus family members expressing such fusion proteins are also provided. Genetically inactivated Bacillus cereus family members and recombinant Bacillus cereus family members that overexpress exosporium proteins are also provided. Seeds coated with the recombinant Bacillus cereus family members and methods for using the recombinant Bacillus cereus family members (e.g., for stimulating plant growth) are also provided. Various modifications of the recombinant Bacillus cereus family members that express the fusion proteins are further provided. Fusion proteins comprising a spore coat protein and a protein or peptide of interest, recombinant bacteria that express such fusion proteins, seeds coated with such recombinant bacteria, and methods for using such recombinant bacteria (e.g., for stimulating plant growth) are also provided.
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