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公开(公告)号：US10251780B2
公开(公告)日：2019-04-09
申请号：US14749487
申请日：2015-06-24
Inventor： Yu-Chong Tai , Yu Zhao , Mark S. Humayun , James D. Weiland
Abstract: A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a receiver coil buried within the body to improve efficiency and robustness to misalignments. One or more of the coils can be manufactured using micromechanical machining techniques to lay out conductors in a ribbon of biocompatible insulator, folding lengths of the insulated conductor traces longitudinally over one another, and then spiraling them into a ring. The traces change axial position in the ring by shifting across fold lines. One or more U-shaped sections on the traces can be folded so that adjacent traces can project opposite one another, lengthening the resulting ribbon that can be wound into a coil.
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公开(公告)号：US20190025610A1
公开(公告)日：2019-01-24
申请号：US16017667
申请日：2018-06-25
Inventor： Yu-Chong Tai , Nicholas E. Scianmarello , Charles M. T. DeBoer , Mark S. Humayun
CPC classification number: G02C7/049 , A61K9/0051 , G02C7/04 , G02C7/041 , G02C7/085
Abstract: A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.
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公开(公告)号：US20180325373A1
公开(公告)日：2018-11-15
申请号：US15948187
申请日：2018-04-09
Inventor： Damien C. Rodger , Yu-Chong Tai , Mark S. Humayun , Aubrey M. Shapero , Abhinav Agarwal , Azita Emami
CPC classification number: A61B3/16 , A61B2562/0247 , A61B2562/166 , A61B2562/168 , A61M1/008 , A61M2205/04 , A61M2210/0612
Abstract: A miniature, low power electronic pressure sensor with a first, oil-filled chamber to protect its microelectromechanical systems (MEMS) pressure sensitive membrane and a second chamber filled with saline or body fluids connected by tube into an organ in the body, such as an eyeball, that needs pressure sensing, is described. The tube carries pressure from a sensitive area within the organ to the electronic pressure sensor. The pressure sensor may communicate wirelessly with external readers and pass data to a server or other computer. Running alongside the tube is another tube for draining and pressure relief. The tubes, or cannulas, can share an opening into the organ in order to minimize the number of holes needed. The tubes may be molded into a single oval cross section, combined coaxially, or share a lumen for a portion that enters the wall of an organ so as to promote healing.
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公开(公告)号：US10117774B2
公开(公告)日：2018-11-06
申请号：US13931007
申请日：2013-06-28
Applicant: University of Southern California
Inventor： Mark S. Humayun , Sean Caffey
Abstract: In various embodiments, a drug-delivery device includes one or more reservoirs that may each contain a therapeutic agent for delivery to a patient.
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公开(公告)号：US20250127610A1
公开(公告)日：2025-04-24
申请号：US18508701
申请日：2023-11-14
Inventor： Yu-Chong Tai , Mark S. Humayun
IPC: A61F2/16
Abstract: An intraocular lens (IOL) has a small, central lens suspended within a pliable housing and, when the housing is filled with liquid, is coaxially aligned with a second small lens embedded in the wall of the housing. The suspension is on a dome- or other-shaped webbing attached to an inner circumference of the wall. When filled with liquid, forces squeezing or pulling the equator of the housing, as with ciliary muscles in the eye, adjust a distance between the lenses in order to adjust focus. Optional haptics may project from points on or above and below the equator. A recess in the posterior hemisphere of the housing can keep cell growth away from an optical axis of the lens system. A third small lens can be embedded in an opposite wall of the housing and coaxially aligned with the other lenses to form a three-lens, ultra-zoom system.
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Patent Agency Ranking
公开(公告)号：US20240149077A1
公开(公告)日：2024-05-09
申请号：US18272774
申请日：2022-01-20
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： Mark S. Humayun , Qifa Zhou , Xuejun Qian , Biju Thomas , Gengxi Lu
IPC: A61N7/00
CPC classification number: A61N7/00 , A61N2007/0026 , A61N2007/0056
Abstract: Retinal disease is responsible for many instances of vision impairment. Often, individuals with vision impaired due to retinal disease continue to have functioning retinal neurons. Thus, systems, methods, and devices to stimulate retinal neurons may restore sight for vision-impaired individuals. Systems, methods, and devices provided herein direct ultrasound energy into retinal neurons and modulate phase and amplitude of ultrasound energy in time and space domains in order to variously stimulate various retinal neurons, generating neural responses consistent with visual reproduction of intended images.
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公开(公告)号：US20240058625A1
公开(公告)日：2024-02-22
申请号：US18210978
申请日：2023-06-16
Applicant: University of Southern California
Inventor： Qifa Zhou , Mark S. Humayun , Gengxi Lu
CPC classification number: A61N7/00 , G02C11/10 , A61N2007/0026
Abstract: Present implementations can include a high-precision neural stimulation device with a high voltage ASIC with an array of transmit control cells, a 2D array of ultrasound transducers, and a coupling for interfacing the high voltage ASIC to the 2D array, where the high voltage ASIC is disposed to receive and store programmable voltage levels. A contact lens structure can include the high-precision neural stimulation device and one or more fluid channels at least partially surrounding the high-precision neural stimulation device.
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38.发明授权公开(公告)号：US11533908B2
公开(公告)日：2022-12-27
申请号：US16658457
申请日：2019-10-21
Applicant: University of Southern California
Inventor： Danhong Zhu , David R. Hinton , Ashish Ahuja , Mark S. Humayun
Abstract: Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
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39.发明申请公开(公告)号：US20220280777A1
公开(公告)日：2022-09-08
申请号：US17685186
申请日：2022-03-02
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： Mark S. Humayun , Gianluca Lazzi , Bodour Salhia , Manjunath Machnoor , Javad Paknahad , Alejandra Gonzalez-Calle , Ben Yi Tew
Abstract: Bioelectronic lens (E-lens) systems for inducing neuroprotective changes in neurons, in particular the retina. A system may include a stimulating electrode configured to be placed on an eye or skin around the eye. The system may further include a return electrode configured such that voltage distribution is focalized to the eye and induced electric fields to an area of interest on the eye or on the skin around the eye are maximized. The electric fields provide neuroprotection and reinnervation.
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公开(公告)号：US20200260946A1
公开(公告)日：2020-08-20
申请号：US16786377
申请日：2020-02-10
Inventor： Yu-Chong Tai , Nicholas E. Scianmarello , Mark S. Humayun
Abstract: A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.
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