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公开(公告)号：US20250127611A1
公开(公告)日：2025-04-24
申请号：US18508702
申请日：2023-11-14
Inventor： Yu-Chong Tai , Mark S. Humayun
IPC: A61F2/16
Abstract: An accommodating intraocular lens (IOL) is formed from an anterior or posterior half molded as a chambered, polymer sack with a mouth opening smaller than its largest width that is mated to another half molded as a pliable bowl having a rim larger than the rest of the half. The resulting shell has a seam that is parallel to and does not cross or touch the equator such that the IOL is asymmetric between its front and back. A circular depression around the optical axis can be made in the anterior and/or posterior half such that a surrounding capsular bag seals against the rim of the depression, and an interior of the depression(s) does not touch the capsular bag.
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公开(公告)号：US12239374B2
公开(公告)日：2025-03-04
申请号：US18344118
申请日：2023-06-29
Inventor： Yu-Chong Tai , Nicholas E. Scianmarello , Mark S. Humayun
Abstract: A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.
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3.发明公开公开(公告)号：US20240100334A1
公开(公告)日：2024-03-28
申请号：US17766600
申请日：2020-10-28
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： Mark S. Humayun , Gianluca Lazzi , Bodour Salhia , Manjunath Machnoor , Javad Paknahad
IPC: A61N1/36 , A61N1/04 , A61N1/40 , C12Q1/6874 , C12Q1/6883
CPC classification number: A61N1/36046 , A61N1/0476 , A61N1/36014 , A61N1/40 , C12Q1/6874 , C12Q1/6883 , C12Q2600/106 , C12Q2600/154
Abstract: Methods, systems, and apparatus for causing changes to cells or tissue within or adjacent to an eye. The system includes an external RF coil configured to transmit RF signals. The system also includes a wearable device configured to be removably disposed on the eye, the wearable device including a plurality of internal radiofrequency (RF) coils configured to receive the RF signals from the external RF coil and a plurality of stimulating electrodes configured to electromagnetically stimulate a portion of the eye or an area adjacent to the eye, causing changes to cells or tissue within or adjacent to the eye.
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公开(公告)号：US11122975B2
公开(公告)日：2021-09-21
申请号：US15948187
申请日：2018-04-09
Inventor： Damien C. Rodger , Yu-Chong Tai , Mark S. Humayun , Aubrey M. Shapero , Abhinav Agarwal , Azita Emami
Abstract: A miniature, low power electronic pressure sensor with a first, oil-filled chamber to protect its microelectromechanical systems (MEMS) pressure sensitive membrane and a second chamber filled with saline or body fluids connected by tube into an organ in the body, such as an eyeball, that needs pressure sensing, is described. The tube carries pressure from a sensitive area within the organ to the electronic pressure sensor. The pressure sensor may communicate wirelessly with external readers and pass data to a server or other computer. Running alongside the tube is another tube for draining and pressure relief. The tubes, or cannulas, can share an opening into the organ in order to minimize the number of holes needed. The tubes may be molded into a single oval cross section, combined coaxially, or share a lumen for a portion that enters the wall of an organ so as to promote healing.
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公开(公告)号：US10849788B2
公开(公告)日：2020-12-01
申请号：US15074909
申请日：2016-03-18
Applicant: University of Southern California
Inventor： Mark S. Humayun , Aldo Oregon , Yi Zhang
Abstract: Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.
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Patent Agency Ranking
公开(公告)号：US10768444B2
公开(公告)日：2020-09-08
申请号：US16017667
申请日：2018-06-25
Inventor： Yu-Chong Tai , Nicholas E. Scianmarello , Charles M. T. DeBoer , Mark S. Humayun
Abstract: A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.
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公开(公告)号：US20190254705A1
公开(公告)日：2019-08-22
申请号：US16280956
申请日：2019-02-20
Applicant: University of Southern California
Inventor： Mark S. Humayun
Abstract: A surgical instrument, and methods for its use, is described that includes clamp heads that can be nestled within or extended from a tubular sheath by longitudinal movement of the clamp heads' tines with respect to the tubular sheath. One of the tines includes an arch that slides against a mouth and inside wall of the tubular sheath, causing the clamp heads to open or close. The clamp heads close lightly, to within a predetermined (or zero) distance from one another, gently grasp an ultrathin polymer substrate seeded with cells, and pulls it within the sheath such that the substrate curls and folds to protect the cells.
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公开(公告)号：US10342698B2
公开(公告)日：2019-07-09
申请号：US15685353
申请日：2017-08-24
Applicant: California Institute of Technology , University of Southern California , Doheny Eye Institute
Inventor： Yu-Chong Tai , Nicholas E. Scianmarello , Karthik Murali , Mark S. Humayun , Ramiro Magalhaes Ribeiro
Abstract: An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
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公开(公告)号：US20160109726A1
公开(公告)日：2016-04-21
申请号：US14881935
申请日：2015-10-13
Inventor： Yu-Chong Tai , Nicholas E. Scianmarello , Charles M. T. DeBoer , Mark S. Humayun
CPC classification number: G02C7/049 , A61K9/0051 , G02C7/04 , G02C7/041 , G02C7/085
Abstract: A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.
Abstract translation: 描述了具有与流量调节器连接到通道的液体储存器的隐形眼镜流体输送装置。 本文描述了其他眼睛水合和可变屈光力隐形眼镜。 还描述了具有通过流量调节器连接到通道的液体储存容器的可植入液体输送装置。 这些装置和装置可用于对象内治疗液体的特定目标递送。 在一些实施例中，装置包括致动室，其提供将流体释放到目标区域（例如眼睛）中的驱动力。 本文所述的致动室可以包含相变材料或渗透室或其组合以驱动流体的释放。
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公开(公告)号：US20150366707A1
公开(公告)日：2015-12-24
申请号：US14744439
申请日：2015-06-19
Inventor： Yu-Chong Tai , Nicholas Scianmarello , Dongyang Kang , Jungwook Park , Mark S. Humayun , Karthik Murali , Amir H. Kashani , Hossein Nazari Khanamiri
CPC classification number: A61F9/0017 , A61F2240/001 , A61F2250/0068 , B29C39/10 , B29C41/36 , B29C65/02 , B29C66/1142 , B29C66/3242 , B29C66/54 , B29C66/71 , B29C66/73754 , B29C66/919 , B29C66/949 , B29K2083/005 , B29L2031/7548
Abstract: A medical device having a permeable bag connected by a non-permeable cannula to a discharge sac is described along with a manufacturing process and surgical implantation method. The permeable portions of the device have pores that are sized to be permeable to a predetermined class of small molecules, such as oxygen, nitrous oxide, or other therapeutic agents. Once absorbed inside the device, the small molecules are then passively transported, by a concentration gradient of the small molecules, to the discharge sac to be disbursed. A metal tube or other strip can be included in the cannula to assist a surgeon in orienting the device within the body.
Abstract translation: 具有通过非渗透性套管连接到排出囊的可渗透袋的医疗装置与制造过程和手术植入方法一起被描述。 装置的可渗透部分具有尺寸适于对预定类型的小分子例如氧气，一氧化二氮或其它治疗剂可渗透的孔。 一旦被吸收在设备内部，小分子就被小分子的浓度梯度被动地运送到排出囊。 套管中可以包括金属管或其它条，以帮助外科医生将装置定向在体内。
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