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公开(公告)号：US07577538B2
公开(公告)日：2009-08-18
申请号：US10554768
申请日：2004-04-28
Applicant: Yongdong Wang
Inventor： Yongdong Wang
IPC: G06F19/00
CPC classification number: G06K9/0057 , H01J49/0036
Abstract: A method for analyzing data from a mass spectrometer including obtaining calibrated mass spectral data involving at least one ion with its isotopes, by processing raw spectral data; obtaining library spectral data which has been processed to form calibrated library data; and performing a regression analysis, preferably using matrix operations, between the calibrated mass spectral data and the calibrated library data; and reporting at least one regression coefficient representative of a relative concentrations of a component in a sample which generated the raw spectral data. The invention is also directed to a mass spectrometer system that operates in accordance with the method, a data library of transformed mass spectra, and a method for producing the data library.
Abstract translation: 一种用于分析来自质谱仪的数据的方法，包括通过处理原始光谱数据获得涉及至少一种具有其同位素的离子的校准质谱数据; 获得已经处理以形成校准库数据的库光谱数据; 并且在校准的质谱数据和校准的库数据之间执行优选使用矩阵运算的回归分析; 并且报告至少一个回归系数，其代表生成原始光谱数据的样品中组分的相对浓度。 本发明还涉及根据该方法操作的质谱仪系统，变换质谱的数据库以及用于产生数据库的方法。
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公开(公告)号：US07529629B2
公开(公告)日：2009-05-05
申请号：US10554863
申请日：2004-04-28
Applicant: Yongdong Wang
Inventor： Yongdong Wang
CPC classification number: G06F19/703 , G06F19/18
Abstract: A method for analyzing data obtained from at least one sample in a separation system (10, 50, 60) that has a capability for separating components of a sample containing more than one component as a function of at least two different variables including obtaining data representative of the at least one sample from the system, the data being expressed as a function of the two variables; forming a data stack (70, 74, 78, 82, 84) having successive levels, each level containing successive data representative of the at least one sample; forming a data array (R) representative of a compilation of all of the data in the data stack; and separating the data array into a series of matrixes. A chemical analysis system that operates in accordance with the method, and a medium having computer readable program code for causing the system to perform the method.
Abstract translation: 一种用于分析从分离系统（10,50,60）中的至少一个样本获取的数据的方法，所述分离系统具有分离包含多于一个分量的样本的分量的能力，作为至少两个不同变量的函数，包括获得数据代表 来自系统的至少一个样本，数据被表示为两个变量的函数; 形成具有连续级别的数据堆栈（70,74,88,82,84），每个级别包含表示所述至少一个样本的连续数据; 形成代表数据堆中所有数据的汇编的数据阵列（R）; 并将数据阵列分成一系列矩阵。 根据该方法操作的化学分析系统和具有用于使系统执行该方法的计算机可读程序代码的介质。
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公开(公告)号：US20060288339A1
公开(公告)日：2006-12-21
申请号：US10554863
申请日：2004-04-28
Applicant: Yongdong Wang
Inventor： Yongdong Wang
IPC: G06F9/45
CPC classification number: G06F19/703 , G06F19/18
Abstract: A method for analyzing data obtained from at least one sample in a separation system (10, 50, 60) that has a capability for separating components of a sample containing more than one component as a function of at least two different variables comprising obtaining data representative of the at least one sample from the system, the data being expressed as a function of the two variables; forming a data stack (70, 74, 78, 82, 84) having successive levels, each level containing successive data representative of the at least one sample; forming a data array (R) representative of a compilation of all of the data in the data stack; and separating the data array into a series of matrixes. A chemical analysis system that operates in accordance with the method, and a medium having computer readable program code for causing the system to perform the method.
Abstract translation: 一种用于分析从分离系统（10,50,60）中的至少一个样本获得的数据的方法，所述分离系统具有分离包含多于一个组分的样品的组分作为至少两个不同变量的函数的能力，包括获得数据代表 来自系统的至少一个样本，数据被表示为两个变量的函数; 形成具有连续级别的数据堆栈（70,74,88,82,84），每个级别包含表示所述至少一个样本的连续数据; 形成代表数据堆中所有数据的汇编的数据阵列（R）; 并将数据阵列分成一系列矩阵。 根据该方法操作的化学分析系统和具有用于使系统执行该方法的计算机可读程序代码的介质。
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公开(公告)号：US20060217911A1
公开(公告)日：2006-09-28
申请号：US10554768
申请日：2004-04-28
Applicant: Yongdong Wang
Inventor： Yongdong Wang
IPC: G06F19/00
CPC classification number: G06K9/0057 , H01J49/0036
Abstract: A method for analyzing data from a mass spectrometer comprising obtaining calibrated continuum spectral data by processing raw spectral data; obtaining library spectral data which has been processed to form calibrated library data; and performing a least squares fit, preferably using matrix operations (equation 1), between the calibrated continuum spectral data and the calibrated library data to determine concentrations of components in a sample which generated the raw spectral data. A mass spectrometer system (FIG. 1) that operates in accordance with the method, a data library of transformed mass spectra, and a method for producing the data library.
Abstract translation: 一种用于分析来自质谱仪的数据的方法，包括通过处理原始光谱数据获得校准的连续谱光谱数据; 获得已经处理以形成校准库数据的库光谱数据; 并且在校准的连续谱数据和校准的库数据之间优选使用矩阵运算（等式1）进行最小二乘拟合，以确定产生原始光谱数据的样本中的分量的浓度。 根据该方法操作的质谱仪系统（图1），变换质谱的数据库以及用于产生数据库的方法。
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公开(公告)号：US6049762A
公开(公告)日：2000-04-11
申请号：US993482
申请日：1997-12-18
Applicant: Alan M. Ganz , Yongdong Wang , David H. Tracy , Robert A. Hoult , Jerry E. Cahill , David A. Huppler
Inventor： Alan M. Ganz , Yongdong Wang , David H. Tracy , Robert A. Hoult , Jerry E. Cahill , David A. Huppler
CPC classification number: G01J3/453 , G01J2003/2866
Abstract: Standardization is achieved for FTIR spectrometric instruments that effect an intrinsic distortion in spectral information, the distortion being associated with an aperture size. An idealized function of spectral line shape is specified. With a small calibration aperture, spectral data is obtained for a basic sample having known "true" spectral data, and standard spectral data also is obtained for a standard sample. With a larger, normal sized aperture, standard spectral data is obtained again for the calibration sample. A transformation factor, that is a function of this data and the standardized function, is applied to spectral data for test samples to effect standardized information. In another embodiment, the standard sample has known true spectral data, and the basic sample is omitted. In either case, the transformation factor is applied to the sample data in logarithm form, the antilogarithm of the result effects the standardized information.
Abstract translation: 对于影响光谱信息中的固有失真的FTIR光谱仪器实现标准化，失真与孔径尺寸相关联。 规定了光谱线形状的理想化功能。 使用小的校准孔径，获得具有已知“真实”光谱数据的基本样品的光谱数据，并且还为标准样品获得标准光谱数据。 对于较大的正常尺寸的孔径，再次为校准样品获得标准光谱数据。 作为该数据和标准化函数的函数的变换因子被应用于测试样本的光谱数据以实现标准化信息。 在另一个实施例中，标准样品具有已知的真实光谱数据，并省略了基本样品。 在任一种情况下，转换因子以对数形式应用于样本数据，结果的反对数效应影响标准化信息。
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Patent Agency Ranking
公开(公告)号：US5559728A
公开(公告)日：1996-09-24
申请号：US237368
申请日：1994-05-03
Applicant: Bruce R. Kowalski , Yongdong Wang
Inventor： Bruce R. Kowalski , Yongdong Wang
CPC classification number: G01N21/274 , G01N30/8672 , G01N2030/025 , G01N2030/626
Abstract: A method for calibrating two-dimensional responses measured on multiple instruments or on a single instrument under different operating conditions. The method calculates two separate banded diagonal transformation matrices using the responses of a common standard sample to simultaneously correct for the response channel shift and intensity variations in both dimensions or orders. The two transformational matrices are estimated from a set of simultaneous non-linear equations via the Gauss-Newton method. The effects of noise and transformation matrix bandwidth on the standardization performance were studied through computer simulation. From computer simulation and experimental data, it was found that the design of the standard sample is crucial for the parameter estimations and response standardization.
Abstract translation: 用于校准在不同操作条件下在多个仪器或单个仪器上测量的二维响应的方法。 该方法使用公共标准样本的响应来计算两个单独的带状对角线变换矩阵，以同时校正两个维度或次序中的响应信道偏移和强度变化。 通过高斯 - 牛顿法从一组同时的非线性方程估计出两个变换矩阵。 通过计算机模拟研究噪声和变换矩阵带宽对标准化性能的影响。 从计算机仿真和实验数据可以看出，标准样本的设计对参数估计和响应标准化至关重要。
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37.发明授权公开(公告)号：US08819512B1
公开(公告)日：2014-08-26
申请号：US12357304
申请日：2009-01-21
Applicant: Yongdong Wang , Hao Zhuang
Inventor： Yongdong Wang , Hao Zhuang
IPC: G08C25/02
CPC classification number: H04L1/08 , H04L49/552 , H04L69/163 , H04L69/166
Abstract: A computer-implemented method for detecting TCP packet losses and expediting packet retransmission is disclosed. The method includes assigning to each packet transmitted or retransmitted a sequential order number; determining from an ACK packet or SACK segment thereof the sequential order number of a received packet; recording the determined sequential order number as a highest order number in case the determined sequential order number is greater than a current received order number, and retransmitting all unacknowledged packets having sequential order numbers less than the highest received order number.
Abstract translation: 公开了一种用于检测TCP分组丢失并加快分组重传的计算机实现的方法。 该方法包括分配发送或重传的每个分组的顺序订单号码; 从ACK分组或其SACK分段确定接收分组的顺序序号; 在确定的顺序号大于当前接收到的订单号码的情况下，将所确定的顺序号码记录为最高订单号码，并且重新发送具有小于最高接收订单号的顺序订单号码的所有未确认的包。
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38.发明授权公开(公告)号：US07670848B2
公开(公告)日：2010-03-02
申请号：US11251873
申请日：2005-10-18
Applicant: Michael R. Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone, legal representative , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
Inventor： Michael R. Gambini , John C. Voyta , John Atwood , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
CPC classification number: G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
Abstract: In a luminescence detecting apparatus and method for analyzing luminescent samples, luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, an infrared filter, and a camera lens, whereupon a focused image is created by the optics on the camera. The use of an infrared filter suppresses stray IR radiation resulting from plate phosphorescence (which can result in abnormally high backgrounds and/or alteration of the image received by the camera).
Abstract translation: 在用于分析发光样品的发光检测装置和方法中，将发光样品放置在托盘中的多个样品孔中，并将该托盘放置在包含电荷耦合器件相机的可见光不透过室中。 在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，红外滤光镜和照相机镜头，由相机上的光学器件产生聚焦图像。 使用红外滤光器可抑制板状磷光产生的杂散红外辐射（可能导致摄像机接收的图像异常高的背景和/或变化）。
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公开(公告)号：US07656521B2
公开(公告)日：2010-02-02
申请号：US12119239
申请日：2008-05-12
Applicant: Yongdong Wang , Bernhard H. Radziuk , David H. Tracy
Inventor： Yongdong Wang , Bernhard H. Radziuk , David H. Tracy
IPC: G01J3/00
Abstract: In a spectroscopic process a sample for producing a test spectral line or spectrum of at least one component contained in the sample is stimulated and the transmitted and/or emitted electromagnetic rays are used to create the test spectral line or spectrum. In order to improve such a spectroscopic process to such an extent that variations of certain parameters, which alter the shape and/or occurrence of a spectral line, are compensated, a comparison spectral line or spectrum of a known comparison material is produced under substantially the same parameters as the sample. The comparison spectral line or spectrum is compared with an ideal comparison spectral line or spectrum in order to calculate a transfer function, andthe transfer function is applied to the test spectral line or spectrum in order to calculate a corrected test spectral line or spectrum.
Abstract translation: 在分光过程中，刺激用于产生测试谱线或样品中包含的至少一种组分的光谱的样品，并且使用透射和/或发射的电磁波来产生测试光谱线或光谱。 为了改进这种光谱过程，使得补偿了改变光谱线的形状和/或出现的某些参数的变化，已知比较材料的比较光谱线或光谱基本上在 与样品相同的参数。 将比较谱线或频谱与理想的比较谱线或频谱进行比较，以计算传递函数，并将传递函数应用于测试谱线或频谱，以便计算校正的测试谱线或频谱。
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公开(公告)号：US20060156792A1
公开(公告)日：2006-07-20
申请号：US11249722
申请日：2005-10-12
Applicant: Yongdong Wang
Inventor： Yongdong Wang
CPC classification number: G01N30/463 , G01N30/466 , G01N30/80 , G01N30/82
Abstract: A multi-dimensional separation system having parallel traps for effluent from prior separation dimension and parallel latter separation columns, the latter columns being coupled to the traps. At least one trap enriches components of effluent while at least one other trap is releasing trapped components to a detector, which may be a mass spectrometer. Internal standards may be provided, as in a release solvent, for the calibration of one of the chromatographic columns and the detection system. The system may comprise a multiple channel selector for multiple streams, wherein all of the streams flow at the same time.
Abstract translation: 一种多维分离系统，其具有用于来自先前分离尺寸和平行的后分离柱的流出物的平行捕集器，后者的塔联接到捕集器。 至少一个陷阱丰富了流出物的组分，而至少一个其他捕集器将捕获的组分释放到可以是质谱仪的检测器。 可以提供内部标准，如在释放溶剂中，用于校准色谱柱和检测系统之一。 该系统可以包括用于多个流的多信道选择器，其中所有流同时流动。
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