公开(公告)号：US20150147558A1

公开(公告)日：2015-05-28

申请号：US14404842

申请日：2013-06-03

Applicant: SYMATESE

Inventor： Vithuy Dao ,  Robert Michelot ,  Benjamin Herbage ,  Fabien Fuchez ,  Eric Perouse

IPC: D06M11/30

CPC classification number: D06M11/30 ,  A61L15/28 ,  A61L15/64 ,  C08B15/04 ,  D06M11/64 ,  D06M13/355 ,  D06M13/388 ,  D06M2101/06 ,  D10B2201/20 ,  Y02P20/582 ,  Y10T428/249921 ,  C08L1/04 ,  C08L1/24

Abstract: The present invention relates to a method of obtaining a solid material based on a polymer having its cellobiose units exhibiting the following characteristics: at least some of the cellobiose units have at least one carboxylic acid function attached to the C6 carbon, the other C6 carbons having a primary alcohol function attached thereto; and at least some of the cellobiose units have at least one of the two rings open between the C2 and C3 carbons, the other C2 and C3 carbons forming a ring and having an alcohol function attached thereto. Such a material, advantageously a textile, may be used as a compress.

Abstract translation: 本发明涉及一种获得基于具有其纤维二糖单元的聚合物的固体材料的方法，所述纤维二糖单元具有以下特征：至少一些纤维二糖单元具有至少一个连接到C 6碳上的羧酸官能团，其它C 6碳具有 附着于其上的伯醇功能; 并且至少一些纤维二糖单元具有两个环中的至少一个在C2和C3碳之间打开，另一个C2和C3碳形成环并具有连接到其上的醇官能团。 这种材料，有利地是织物可以用作压缩。

公开(公告)号：US08951989B2

公开(公告)日：2015-02-10

申请号：US13263364

申请日：2010-04-09

Applicant: Mark E. Wagman

Inventor： Mark E. Wagman

IPC: A61K31/70 ,  A61K31/715 ,  C08L5/08 ,  C08L5/12 ,  C08L71/02 ,  A61K31/717 ,  A61K31/718 ,  A61K31/719 ,  A61K31/721 ,  A61L24/00 ,  A61L24/04 ,  A61L31/04 ,  A61L31/14 ,  C08L1/04 ,  C08L3/10 ,  C08L5/02

CPC classification number: A61L24/0031 ,  A61L24/0042 ,  A61L24/043 ,  A61L31/041 ,  A61L31/145 ,  A61L31/148 ,  C08L1/04 ,  C08L3/10 ,  C08L5/02 ,  C08L5/08 ,  C08L5/12 ,  C08L71/02

Abstract: A hydrogel tissue adhesive having decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm polyether amine in the presence of an oligomer additive, which promotes the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, such as a hemostat sealant or to prevent undesired tissue-to-tissue adhesions resulting from trauma or surgery.

Abstract translation: 描述了具有降低的降解时间的水凝胶组织粘合剂。 水凝胶组织粘合剂通过使氧化多糖与水分散性多臂聚醚胺在低聚物添加剂的存在下反应形成，其促进水凝胶的降解。 水凝胶可用作用于医疗应用的组织粘合剂或密封剂，例如止血剂密封剂或用于防止由创伤或手术引起的不希望的组织与组织粘连。

公开(公告)号：US20140364514A1

公开(公告)日：2014-12-11

申请号：US14362652

申请日：2012-11-30

Applicant: FMC CORPORATION

Inventor： Zheng Tan ,  Michael Sestrick ,  Nadia Yaranossian ,  Jeremy Ondov

IPC: B01F17/00 ,  A61K47/38 ,  A61K8/73 ,  A01N25/22 ,  A23C9/154 ,  A23L1/0534 ,  A23L1/0522 ,  A23L1/054 ,  A23L2/62 ,  A61K47/36 ,  A23L1/0524

CPC classification number: C08L1/04 ,  A01N25/22 ,  A23C9/1544 ,  A23C11/103 ,  A23L2/52 ,  A23L2/62 ,  A23L2/66 ,  A23L29/262 ,  A23V2002/00 ,  A61K8/731 ,  A61K8/732 ,  A61K47/36 ,  A61K47/38 ,  A61K2800/10 ,  A61K2800/5922 ,  A61Q11/00 ,  A61Q19/00 ,  B01F17/0092 ,  C08L1/286 ,  C08L2205/02

Abstract: The present invention is directed to a co-attrited stabilizer composition comprising: a) microcrystalline cellulose in an amount of from 20%-90% by weight of the composition; b) a hydrocolloid in an amount of from 5%-50% by weight of the composition, wherein the hydrocolloid is selected from at least one member of the group consisting of carboxymethyl cellulose having a degree of substitution of at least 0.95, pectin, alginate, carrageenan, xanthan gum, agar gum, wellan gum, or gellan gum; and c) a starch in an amount of from 5%-50% by weight of the composition, wherein the stabilizer composition has a gel strength (G′) of at least 25 Pa when measured after 24 hours in a 2.6% solids water dispersion at 20° C. The composition is useful as a stabilizer, particularly in food and beverage products.

Abstract translation: 本发明涉及一种共磨性稳定剂组合物，其包含：a）组合物的20重量％-90重量％的微晶纤维素; b）组合物的5重量％-50重量％的水胶体，其中所述水胶体选自至少一种取代度至少为0.95的羧甲基纤维素，果胶，藻酸盐 ，角叉菜胶，黄原胶，琼脂，福冈胶或吉兰糖胶; 和c）组合物重量的5％-50％的淀粉，其中稳定剂组合物在2.6％固体水分散体中测定24小时后的凝胶强度（G'）至少为25Pa 在20℃下。该组合物可用作稳定剂，特别是在食品和饮料产品中。

公开(公告)号：US20140171521A1

公开(公告)日：2014-06-19

申请号：US14237688

申请日：2012-08-10

Applicant: Kouichirou Enatsu ,  Haruko Obata ,  Naoaki Yamasaki

Inventor： Kouichirou Enatsu ,  Haruko Obata ,  Naoaki Yamasaki

IPC: A23C3/08 ,  A61K47/38 ,  C09D7/12 ,  A23F5/14 ,  A23G1/56

CPC classification number: A23C3/08 ,  A23C9/1544 ,  A23F3/163 ,  A23F5/14 ,  A23F5/243 ,  A23G1/56 ,  A23L2/02 ,  A23L2/52 ,  A23L2/62 ,  A23L29/262 ,  A23V2002/00 ,  A61K9/0095 ,  A61K47/38 ,  C08L1/02 ,  C08L1/04 ,  C08L1/286 ,  C08L5/00 ,  C08L2203/02 ,  C08L2205/02 ,  C09D7/65

Abstract: A cellulose composite which contains a cellulose and a polysaccharide and which is characterized in that the median diameter of colloidal cellulose composites contained in the cellulose composite is 0.85 μm or more as measured by a dynamic light scattering method.

Abstract translation: 一种纤维素复合体，其含有纤维素和多糖，其特征在于，通过动态光散射法测定，所述纤维素复合体中所含的胶体纤维素复合体的中值粒径为0.85μm以上。

公开(公告)号：US20140148845A1

公开(公告)日：2014-05-29

申请号：US13878881

申请日：2011-10-11

Applicant: Evan Richard Geller

Inventor： Evan Richard Geller

IPC: A61B17/08

CPC classification number: A61L31/042 ,  A61B17/0493 ,  A61B17/08 ,  A61B2017/00004 ,  A61B2017/00893 ,  A61B2090/0816 ,  A61F2/0063 ,  A61F2002/009 ,  A61F2210/0004 ,  A61K31/10 ,  A61L31/10 ,  A61L31/14 ,  A61L31/148 ,  C08L1/04 ,  C08L1/26 ,  C08L5/08

Abstract: Surgical devices and methods are provided for preventing the formation of post-operative adhesions. In one device, an envelope of bioabsorbable material defines at least one opening, and a layer of bioabsorbable adhesion-preventing material is disposed on an exterior surface of the envelope. A rigid or semi-rigid barrier member is at least partially disposed in a space inside the envelope, without adhering to the envelope such that the barrier member can be pulled out of the envelope through the opening. In another device, a rigid or semi-rigid barrier member is removably attached to a layer of bioabsorbable adhesion-preventing material by a controlled adhesive. In another device, a rigid or semi-rigid bioabsorbable barrier member, such as compressed cellulose, is attached to a layer of bioabsorbable adhesion-preventing material. The envelope of bioabsorbable material may include cellulose or oxidized regenerated cellulose. The adhesion-preventing material may include chemically modified sodium hyaluronate and carboxymethylcellulose.

Abstract translation: 提供了用于防止术后粘连形成的手术装置和方法。 在一个装置中，生物可吸收材料的包膜限定至少一个开口，并且一层生物可吸收的防粘连材料设置在外壳的外表面上。 刚性或半刚性阻挡构件至少部分地设置在外壳内的空间中，而不粘附到外壳上，使得阻挡构件能够通过开口被拉出外壳。 在另一种装置中，刚性或半刚性阻挡构件通过受控粘合剂可移除地附接到生物可吸收的防粘连材料层。 在另一种装置中，刚性或半刚性的生物可吸收阻挡构件，例如压缩纤维素，附着在生物可吸收的防粘连材料层上。 生物可吸收材料的包膜可以包括纤维素或氧化再生纤维素。 防粘附材料可包括化学改性的透明质酸钠和羧甲基纤维素。

公开(公告)号：US20140005377A1

公开(公告)日：2014-01-02

申请号：US13927315

申请日：2013-06-26

Applicant: Covidien LP ,  Confluent Surgical, Inc.

Inventor： Valentino Tramontano ,  Phillip Blaskovich ,  Rachit Ohri ,  Daniel S. Costa ,  Joshua Kennedy ,  Sajida Farooqi

IPC: C08B15/00 ,  C08B15/02

CPC classification number: C08B15/00 ,  C08B1/003 ,  C08B15/02 ,  C08J3/14 ,  C08J2301/04 ,  C08L1/04

Abstract: A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one neutralizing agent to form a plurality of modified cellulose particles.

Abstract translation: 溶解改性纤维素的方法包括使改性纤维素溶液与至少一种中和剂接触以形成多个改性纤维素颗粒。

公开(公告)号：US20130345728A1

公开(公告)日：2013-12-26

申请号：US14003529

申请日：2012-03-16

Applicant: Julie Lecuivre

Inventor： Julie Lecuivre

IPC: A61F2/00

CPC classification number: A61F2/0063 ,  A61F2002/0068 ,  A61F2002/009 ,  A61F2210/0076 ,  A61F2230/0008 ,  A61F2240/001 ,  A61F2250/0031 ,  A61F2250/0051 ,  A61L27/16 ,  A61L27/34 ,  A61L31/06 ,  A61L31/08 ,  A61L31/146 ,  A61L31/148 ,  D04B21/12 ,  D10B2403/0213 ,  D10B2509/08 ,  C08L1/04 ,  C08L89/06 ,  C08L5/08

Abstract: The present invention relates to a prosthesis (100) comprising an openworked three-dimensional knit (101) comprising a front face and a rear face, each face being formed with one or more laps of yarns defining pores on said face, the front face being bound to the rear face by connecting yarns defining a spacer, characterized in that the connecting yarns are distributed so that they define an entanglement of yarns crossing each other at the spacer, without obstructing the pores of the front and rear faces.

Abstract translation: 本发明涉及一种假体（100），其包括开放的三维针织物（101），其包括前表面和后表面，每个面在所述面上形成一个或多个限定孔的纱线，前面是 通过连接限定了间隔件的纱线，将连接纱线分开，使得它们分开，使得它们限定了在间隔件处彼此交叉的纱线的缠结，而不妨碍前后面孔的孔。

公开(公告)号：US08580951B2

公开(公告)日：2013-11-12

申请号：US12996477

申请日：2010-07-01

Applicant: Helen S. M. Lu ,  Steven W. Shuey

Inventor： Helen S. M. Lu ,  Steven W. Shuey

IPC: C08B1/00 ,  C08B11/02 ,  C08B11/04 ,  C08B11/08 ,  C08B11/12 ,  C08B31/18 ,  C08B37/02 ,  C08B37/12 ,  C08B37/18 ,  C08L1/02 ,  C08L1/28 ,  C08L5/02 ,  C08L5/08 ,  C08L5/12

CPC classification number: C08B37/00 ,  C08B15/02 ,  C08B31/18 ,  C08B37/0021 ,  C08B37/0054 ,  C08L1/04 ,  C08L3/10 ,  C08L5/00 ,  C08L5/02

Abstract: Novel aldehyde-functionalized polysaccharide compositions are described that are more stable in aqueous solution than oxidized polysaccharides or other types of polysaccharides containing pendant aldehyde groups. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.

Abstract translation: 描述了新型醛官能化多糖组合物，其在水溶液中比氧化多糖或其它类型的含醛侧基的多糖更稳定。 醛官能化多糖可以与各种含胺聚合物反应以形成可用于医学应用的水凝胶组织粘合剂和密封剂，例如伤口闭合，补充或替换缝合或缝合在内部外科手术如肠吻合和血管吻合中 ，组织修复，防止流体如血液，胆汁，胃肠道液体和脑脊液的渗漏，眼科手术，药物递送和预防手术后粘连。

公开(公告)号：US20130256365A1

公开(公告)日：2013-10-03

申请号：US13433118

申请日：2012-03-28

Applicant: Frederick E. Shelton, IV ,  Jeffrey S. Swayze ,  Chunlin Yang ,  Cortney E. Henderson ,  Taylor W. Aronhalt ,  Charles J. Scheib ,  Jeffrey L. Aldridge ,  Katherine J. Schmid

Inventor： Frederick E. Shelton, IV ,  Jeffrey S. Swayze ,  Chunlin Yang ,  Cortney E. Henderson ,  Taylor W. Aronhalt ,  Charles J. Scheib ,  Jeffrey L. Aldridge ,  Katherine J. Schmid

IPC: A61B17/068

CPC classification number: A61B17/0643 ,  A61B17/00491 ,  A61B17/0644 ,  A61B17/0684 ,  A61B17/072 ,  A61B17/07207 ,  A61B17/07292 ,  A61B17/1155 ,  A61B17/2909 ,  A61B2017/00004 ,  A61B2017/00314 ,  A61B2017/00327 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/0053 ,  A61B2017/00818 ,  A61B2017/00884 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61B2017/00938 ,  A61B2017/00942 ,  A61B2017/00951 ,  A61B2017/07228 ,  A61B2017/07235 ,  A61B2017/07242 ,  A61B2017/07264 ,  A61B2017/07271 ,  A61B2017/07278 ,  A61B2017/07285 ,  A61B2017/2908 ,  A61B2017/2919 ,  A61B2017/2923 ,  A61B2017/2927 ,  A61B2017/2933 ,  A61B2017/2936 ,  A61B2017/2946 ,  A61B2017/320052 ,  A61B2090/037 ,  A61B2090/0811 ,  A61L31/042 ,  A61L31/129 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  C08L1/04

Abstract: In various embodiments, a tissue thickness compensator can comprise a plurality of fibers. In at least one embodiment, such fibers can include a plurality of first fibers comprised of a first material and a plurality of second fibers comprised of a second material. A tissue thickness compensator can comprise a plurality of layers wherein each layer can be comprised of one or more medicaments. Certain embodiments are disclosed herein for manufacturing a tissue thickness compensator comprising fibers, for example.

Abstract translation: 在各种实施例中，组织厚度补偿器可包括多根纤维。 在至少一个实施例中，这种纤维可以包括由第一材料和由第二材料组成的多个第二纤维组成的多个第一纤维。 组织厚度补偿器可以包括多个层，其中每个层可以由一种或多种药物组成。 本文公开了一些实施例来制造例如包含纤维的组织厚度补偿器。

公开(公告)号：US08377906B2

公开(公告)日：2013-02-19

申请号：US12359000

申请日：2009-01-23

Applicant: Uri Herzberg ,  Jie Jenny Yuan

Inventor： Uri Herzberg ,  Jie Jenny Yuan

IPC: A61K31/717 ,  A61K31/715

CPC classification number: A61L31/16 ,  A61L31/042 ,  A61L31/148 ,  A61L2300/41 ,  C08L1/04

Abstract: Disclosed are compositions and methods for preventing or reducing postoperative ileus and gastric stasis. Such compositions comprise a combination of an oxidized regenerated cellulose component and a non-steroidal anti-inflammatory drug (NSAID) which functions as an inhibitor of cyclooxygenase enzyme (Cox) activity. Such methods comprise administering an effective amount of the composition directly to the serosal surfaces of the gastrointestinal and other visceral organs.

Abstract translation: 公开了用于预防或减少术后肠梗阻和胃潴留的组合物和方法。 这样的组合物包含氧化再生纤维素组分和用作环氧合酶（Cox）活性抑制剂的非甾体抗炎药物（NSAID）的组合。 这样的方法包括将有效量的组合物直接施用于胃肠和其它内脏器官的浆膜表面。