Antibiotic composition from alcaligenes species and method for making and using the same
    37.
    发明授权
    Antibiotic composition from alcaligenes species and method for making and using the same 失效
    来自产碱杆菌种的抗生素组合物及其制备和使用方法

    公开(公告)号:US06224863B1

    公开(公告)日:2001-05-01

    申请号:US09201754

    申请日:1998-12-01

    CPC classification number: A61K35/74 C12P1/04 C12R1/05

    Abstract: A method and composition for treating a bacterial infection in humans and animals is disclosed. The composition contains an anti-bacterial agent that inhibits or kills a variety of Gram-negative and Gram-positive pathogenic bacteria, including several previously shown to be drug-resistant. In particular, the anti-bacterial agent comprises an antibiotic produced by members of the Alcaligenes genus. For instance, in one embodiment, the antibiotic is produced by the M3A strain of Alcaligenes faecalis. The antibiotic of the present invention can be administered parenterally or via a mucosal route.

    Abstract translation: 公开了用于治疗人和动物细菌感染的方法和组合物。 该组合物包含抑制或杀死各种革兰氏阴性和革兰氏阳性病原菌的抗菌剂,包括先前显示为耐药性的几种。 特别地,抗菌剂包括由产碱杆菌属的成员产生的抗生素。 例如,在一个实施方案中,抗生素由粪肠杆菌的M3A菌株产生。 本发明的抗生素可以肠胃外给药或通过粘膜途径给药。

    Biologically pure culture of Alcaligenes faecalis DSM 6335
    39.
    发明授权
    Biologically pure culture of Alcaligenes faecalis DSM 6335 失效
    产碱乳杆菌DSM 6335的生物学纯培养

    公开(公告)号:US5270203A

    公开(公告)日:1993-12-14

    申请号:US903765

    申请日:1992-06-25

    Applicant: Andreas Kiener

    Inventor: Andreas Kiener

    CPC classification number: C12R1/05 C12P17/12

    Abstract: The invention is a biologically pure culture of Alcaligenes faecalis DSM 6335. Furthermore, the culture or a mutant thereof, is capable of growing with 2-cyanopyridine as the sole carbon, nitrogen and energy source in order to produce 6-hydroxypicolinic acid. The specific reaction is the conversion of 2-cyanopyridine as the substrate into 6-hydroxypicolinic acid.

    Abstract translation: 本发明是粪肠杆菌DSM 6335的生物学纯培养物。此外,培养物或其突变体能够以2-氰基吡啶作为唯一的碳,氮和能源生长,以产生6-羟基吡啶甲酸。 具体的反应是将2-氰基吡啶作为底物转化为6-羟基吡啶甲酸。

    Alcaligenes faecalis strains useful for the microbiological process for
the production of 6-hydroxypicolinic acid
    40.
    发明授权
    Alcaligenes faecalis strains useful for the microbiological process for the production of 6-hydroxypicolinic acid 失效
    产碱杆菌粪便菌株可用于生产6-羟基吡啶甲酸的微生物过程

    公开(公告)号:US5268294A

    公开(公告)日:1993-12-07

    申请号:US887884

    申请日:1992-05-26

    CPC classification number: C12R1/05 C12P17/12 Y10S435/829

    Abstract: A microbiological process for the production of 6-hydroxypicolinic acid starting from picolinic acid and/or its salts. The concentration of picolinic acid and/or its salts is selected so that the 6-hydroxypicolinic acid is not further metabolized. The process is performed either by microorganisms of genus Pseudomonas, Bacillus, Alcaligenes, Aerococcus, or Rhodotorula, or with biomass using picolinic acid, which grow with picolinic acid as the sole carbon, nitrogen and energy source.

    Abstract translation: 从吡啶甲酸和/或其盐开始生产6-羟基吡啶甲酸的微生物过程。 选择吡啶甲酸和/或其盐的浓度使得6-羟基吡啶甲酸不被进一步代谢。 该方法由假单胞菌属,芽孢杆菌属,产碱杆菌属,Aerococcus属或红酵母属的微生物或与使用吡啶甲酸作为唯一碳,氮和能源生长的吡啶甲酸的生物质进行。

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