公开(公告)号：US20140042313A1

公开(公告)日：2014-02-13

申请号：US14055440

申请日：2013-10-16

Applicant: Illinois State University

Inventor： Christopher C. Mulligan

IPC: H01J49/16

CPC classification number: H01J49/167 ,  H01J49/0445 ,  H01J49/0468

Abstract: A high sensitivity desorption electrospray ionization mass spectrometry system that employs a heated platform, along with means for directing a liquid stream containing an analyte of interest onto a target location on the heated platform to heat the stream, an electrospray emitter for generating an electrospray and directing the electrospray at the target location on the heated platform to produce an ionized, desorbed analyte, and a mass spectrometer for receiving and detecting the ionized, desorbed analyte.

Abstract translation: 采用加热平台的高灵敏度解吸电喷雾电离质谱系统，以及用于将含有感兴趣分析物的液体流引导到加热平台上的目标位置以加热流的装置，用于产生电喷雾和引导的电喷射发射器 在加热的平台上的目标位置处的电喷雾以产生离子化的解吸附的分析物，以及用于接收和检测电离的解吸附的分析物的质谱仪。

公开(公告)号：US08513598B2

公开(公告)日：2013-08-20

申请号：US12338623

申请日：2008-12-18

Applicant: David P. Fergenson ,  Eric E. Gard

Inventor： David P. Fergenson ,  Eric E. Gard

IPC: H01J49/40

CPC classification number: H01J49/40 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/164

Abstract: A system according to one embodiment includes a particle accelerator that directs a succession of polydisperse aerosol particles along a predetermined particle path; multiple tracking lasers for generating beams of light across the particle path; an optical detector positioned adjacent the particle path for detecting impingement of the beams of light on individual particles; a desorption laser for generating a beam of desorbing light across the particle path about coaxial with a beam of light produced by one of the tracking lasers; and a controller, responsive to detection of a signal produced by the optical detector, that controls the desorption laser to generate the beam of desorbing light. Additional systems and methods are also disclosed.

Abstract translation: 根据一个实施方案的系统包括颗粒促进剂，其引导一系列多分散气溶胶颗粒沿着预定的颗粒路径; 用于在颗粒路径上产生光束的多个跟踪激光器; 位于颗粒路径附近的光学检测器，用于检测单个颗粒上的光束的撞击; 解吸激光器，用于产生与所述跟踪激光器之一产生的光束同轴的所述粒子路径上的解吸光束; 以及控制器，响应于检测由光学检测器产生的信号，其控制解吸激光器以产生解吸光束。 还公开了附加的系统和方法。

公开(公告)号：US08438939B1

公开(公告)日：2013-05-14

申请号：US12881906

申请日：2010-09-14

Applicant: Daniel R. Wiederin

Inventor： Daniel R. Wiederin

IPC: B01L3/02

CPC classification number: B01F13/0222 ,  B01F13/0205 ,  B01F2215/0037 ,  G01N1/22 ,  G01N2035/00544 ,  H01J49/0445 ,  H01J49/105

Abstract: A sample introduction system provides mixing of a sample and a diluent within the container via gas injection. In one or more implementations, the sample introduction system causes a probe of an autosampler to be inserted into a container containing a sample and a diluent so that an end of the probe is submerged beneath a surface of the diluent and the sample. Gas is then injected through the probe to mix the sample and the diluent within the container. An aliquot of the mixed sample and diluent is then withdrawn through the probe.

Abstract translation: 样品引入系统通过气体注入提供容器内的样品和稀释剂的混合。 在一个或多个实施方案中，样品引入系统使得自动进样器的探针插入容纳样品和稀释剂的容器中，使得探针的一端浸没在稀释剂和样品的表面下方。 然后通过探针注入气体以将样品和稀释剂混合在容器内。 然后通过探针取出混合样品和稀释剂的等分试样。

公开(公告)号：US20120298858A1

公开(公告)日：2012-11-29

申请号：US13561365

申请日：2012-07-30

Applicant: Peter T.A. Reilly

Inventor： Peter T.A. Reilly

IPC: H01J49/26 ,  H01J49/40

CPC classification number: H01J49/04 ,  H01J49/0445 ,  H01J49/0481 ,  H01J49/161

Abstract: An aerosol particle analyzer includes a laser ablation chamber, a gas-filled conduit, and a mass spectrometer. The laser ablation chamber can be operated at a low pressure, which can be from 0.1 mTorr to 30 mTorr. The ablated ions are transferred into a gas-filled conduit. The gas-filled conduit reduces the electrical charge and the speed of ablated ions as they collide and mix with buffer gases in the gas-filled conduit. Preferably, the gas filled-conduit includes an electromagnetic multipole structure that collimates the nascent ions into a beam, which is guided into the mass spectrometer. Because the gas-filled conduit allows storage of vast quantities of the ions from the ablated particles, the ions from a single ablated particle can be analyzed multiple times and by a variety of techniques to supply statistically meaningful analysis of composition and isotope ratios.

Abstract translation: 气溶胶粒子分析仪包括激光烧蚀室，充气管道和质谱仪。 激光烧蚀室可以在低压下操作，其可以为0.1mTorr至30mTorr。 将烧蚀的离子转移到充气管道中。 充气导管减少了电荷和消融离子的速度，因为它们与气体填充导管中的缓冲气体碰撞并混合。 优选地，气体填充导管包括电磁多极结构，其将新生离子准直成束，其被引导到质谱仪中。 由于气体填充的管道允许从烧蚀的颗粒中储存大量的离子，可以多次分析来自单个消融颗粒的离子，并通过各种技术分析组成和同位素比率的统计学上有意义的分析。

公开(公告)号：US08288716B2

公开(公告)日：2012-10-16

申请号：US12418891

申请日：2009-04-06

Applicant: Peter T. A. Reilly

Inventor： Peter T. A. Reilly

IPC: H01J49/40

CPC classification number: H01J49/04 ,  H01J49/0445 ,  H01J49/0481 ,  H01J49/161

Abstract: An aerosol particle analyzer includes a laser ablation chamber, a gas-filled conduit, and a mass spectrometer. The laser ablation chamber can be operated at a low pressure, which can be from 0.1 mTorr to 30 mTorr. The ablated ions are transferred into a gas-filled conduit. The gas-filled conduit reduces the electrical charge and the speed of ablated ions as they collide and mix with buffer gases in the gas-filled conduit. Preferably, the gas filled-conduit includes an electromagnetic multipole structure that collimates the nascent ions into a beam, which is guided into the mass spectrometer. Because the gas-filled conduit allows storage of vast quantities of the ions from the ablated particles, the ions from a single ablated particle can be analyzed multiple times and by a variety of techniques to supply statistically meaningful analysis of composition and isotope ratios.

Abstract translation: 气溶胶粒子分析仪包括激光烧蚀室，充气管道和质谱仪。 激光烧蚀室可以在低压下操作，其可以为0.1mTorr至30mTorr。 将烧蚀的离子转移到充气管道中。 充气导管减少了电荷和消融离子的速度，因为它们与气体填充导管中的缓冲气体碰撞并混合。 优选地，气体填充导管包括电磁多极结构，其将新生离子准直成束，其被引导到质谱仪中。 由于气体填充的管道允许从烧蚀的颗粒中储存大量的离子，可以多次分析来自单个消融颗粒的离子，并通过各种技术分析组成和同位素比率的统计学上有意义的分析。

公开(公告)号：US20120018628A1

公开(公告)日：2012-01-26

申请号：US12742093

申请日：2008-11-13

Applicant: Arjan Laurens Wuijckhuijse ,  Charles Kientz ,  Carla Degenhardt-Langelaan

Inventor： Arjan Laurens Wuijckhuijse ,  Charles Kientz ,  Carla Degenhardt-Langelaan

IPC: H01J49/26

CPC classification number: H01J49/0418 ,  H01J49/0445 ,  Y10T436/24

Abstract: Matrix for real-time aerosol mass spectrometry of atmospheric aerosols and real-time aerosol MALDI MS method Abstract The invention is directed to a matrix material for MALDI mass spectrometry, to a matrix composition for MALDI mass spectrometry, in particular for aerosol MALDI mass spectrometry, to a MALDI mass spectrometry method, in particular an aerosol MALDI mass spectrometry method, to the use of a specific compound as a MALDI matrix material, and to the use of a MALDI matrix composition in a gas phase coating method. The matrix material of the invention comprises a 2-mercapto-4,5-dialkylthiazole according to formula (I), wherein X is chosen from S, O or N, and wherein R1 and R2 are independently chosen from hydrogen, methyl, methoxy, ethoxy, and propoxy, or wherein R1 and R2 are taken together to form an optionally substituted aromatic ring structure, optionally comprising one or more heteroatoms, or a tautomeric form thereof. A matrix composition preferably includes the matrix material and an alcohol. The alcohol can be halogenated. The MALDI MS method comprises contacting the analyte with the matrix material or the matrix composition; ionising at least part of the analyte, and separating the ionised components using a mass spectrometer, e.g. TOF-MS. Preferably, bioaerosols are contacted with the matrix material in the gas phase.

Abstract translation: 用于大气气溶胶和实时气溶胶的实时气溶胶质谱的基质MALDI MS方法摘要本发明涉及用于MALDI质谱法的基质材料，用于MALDI质谱法的基质组合物，特别是气相MALDI质谱法， 以MALDI质谱法，特别是气溶胶MALDI质谱法，使用特定化合物作为MALDI基质材料，以及在气相涂布法中使用MALDI基质组合物。 本发明的基质材料包含式（I）的2-巯基-4,5-二烷基噻唑，其中X选自S，O或N，并且其中R 1和R 2独立地选自氢，甲基，甲氧基， 乙氧基和丙氧基，或其中R 1和R 2一起形成任选取代的芳环结构，任选地包含一个或多个杂原子或其互变异构体。 基质组合物优选包括基质材料和醇。 酒精可以被卤化。 MALDI MS方法包括使分析物与基质材料或基质组合物接触; 电离至少部分分析物，并使用质谱仪分离离子化的组分，例如。 TOF-MS。 优选地，生物气溶胶在气相中与基质材料接触。

公开(公告)号：US08058611B2

公开(公告)日：2011-11-15

申请号：US12565598

申请日：2009-09-23

Applicant: Eloy R. Wouters ,  Christopher Mullen ,  Maurizio A. Splendore ,  R. Paul Atherton

Inventor： Eloy R. Wouters ,  Christopher Mullen ,  Maurizio A. Splendore ,  R. Paul Atherton

IPC: H01J49/26

CPC classification number: H01J49/0445

Abstract: A system for preventing backflow as part of an ion source arrangement is introduced. Such a system incorporates a novel continuous flow guide within a source, such as an API ion source. In the spray direction, the cross-sectional area that defines the first portion of the internal volume initially decreases in a convergent-like manner and thereafter increases in a divergent-like manner towards the exit opening of the source housing. Such a flow guide has been designed as an integral part of an ion source housing to provide for an optimal unidirectional flow past a sampling orifice of a mass spectrometer inlet. Accordingly, the novel design of the present invention prevents recirculation and thus minimizes carryover, chemical noise, and source turbulence and as an added benefit, enables a user to easily clean such a system during maintenance.

Abstract translation: 引入了用于防止作为离子源装置的一部分的回流的系统。 这样的系统在源内包含新颖的连续流动引导件，例如API离子源。 在喷射方向上，限定内部容积的第一部分的横截面面积首先以收敛方式减小，然后以发散方式朝向源壳体的出口开口增加。 这种流动引导件已被设计为离子源壳体的组成部分，以提供通过质谱仪入口的采样孔的最佳单向流动。 因此，本发明的新颖设计防止再循环，从而使携带，化学噪声和源湍流最小化，并且作为附加的益处，使得用户能够在维护期间容易地清洁这样的系统。

公开(公告)号：US08035088B2

公开(公告)日：2011-10-11

申请号：US12593313

申请日：2008-03-19

Applicant: Michael J. Tomany ,  Joseph A. Jarrell ,  Stanislaw Koziol ,  Wade P. Leveille

Inventor： Michael J. Tomany ,  Joseph A. Jarrell ,  Stanislaw Koziol ,  Wade P. Leveille

IPC: H01J49/04 ,  H01J49/26 ,  B01D59/44

CPC classification number: G01N30/724 ,  H01J49/0445 ,  Y10T29/49718 ,  Y10T137/85938

Abstract: The invention comprises apparatus for use with atmospheric pressure ionization sources in which an aerosol is formed from a solution of a sample. The aerosol is received in a hollow member and discharged outside the chamber of the ionization source in order to reduce contamination of the ionization source itself by involatile material in the solution and by previously analysed samples. The hollow member is easily removable from the ionization source to facilitate cleaning and replacement. Ionization sources, mass spectrometers, and ion mobility spectrometers comprising the apparatus are also described.

Abstract translation: 本发明包括与大气压电离源一起使用的装置，其中气溶胶由样品溶液形成。 气溶胶被容纳在中空构件中并且排出到电离源的室外，以便通过溶液中的非挥发性材料和先前分析的样品来减少电离源本身的污染。 中空构件容易从电离源移除，以便于清洁和更换。 还描述了包括该装置的电离源，质谱仪和离子迁移谱仪。

公开(公告)号：US20110204220A1

公开(公告)日：2011-08-25

申请号：US13059947

申请日：2009-08-21

Applicant: Arjan Laurens van Wuijckhuijse ,  Rene Parchen

Inventor： Arjan Laurens van Wuijckhuijse ,  Rene Parchen

IPC: H01J49/26

CPC classification number: G01N1/38 ,  G01N2035/1041 ,  H01J49/0445 ,  H01J49/164

Abstract: Biological material is detected in a sample using a MALDI-MS technique (Matrix Assisted Laser Desorption and Ionization-Mass Spectroscopy). A liquid comprising the sample and a MALDI matrix material is prepared and used to form a continuous stream of the liquid. The stream is separated into successive parts to form drops, which are launched into flight, or the stream is launched into flight and then separated into drops. Drop forming techniques may be used that are known from ink jet printers. Material from the drops is ionized while in flight. Mass spectra from the ionized material of respective drops are measured. Preferably, before the drops are formed the liquid is diluted to a level where the majority of drops at most one micro-organism is present per drop.

Abstract translation: 使用MALDI-MS技术（Matrix Assisted Laser Desorption and Ionization-Mass Spectroscopy）在样品中检测生物材料。 制备包含样品和MALDI基质材料的液体并用于形成连续的液体流。 流被分离成连续的部分以形成液滴，其被发射到飞行中，或者流被发射到飞行中，然后分离成液滴。 可以使用从喷墨打印机已知的液滴成形技术。 液滴中的物质在飞行中被电离。 测量各滴的离子化物质的质谱。 优选地，在液滴形成之前，将液体稀释到其中每滴存在多达一个微生物的大多数滴的水平。

公开(公告)号：US20110068263A1

公开(公告)日：2011-03-24

申请号：US12565598

申请日：2009-09-23

Applicant: Eloy R. WOUTERS ,  Christopher MULLEN ,  Maurizio A. SPLENDORE ,  R. Paul ATHERTON

Inventor： Eloy R. WOUTERS ,  Christopher MULLEN ,  Maurizio A. SPLENDORE ,  R. Paul ATHERTON

IPC: H01J49/26

CPC classification number: H01J49/0445

Abstract: A system for preventing backflow as part of an ion source arrangement is introduced. Such a system incorporates a novel continuous flow guide within a source, such as an API ion source. In the spray direction, the cross-sectional area that defines the first portion of the internal volume initially decreases in a convergent-like manner and thereafter increases in a divergent-like manner towards the exit opening of the source housing. Such a flow guide has been designed as an integral part of an ion source housing to provide for an optimal unidirectional flow past a sampling orifice of a mass spectrometer inlet. Accordingly, the novel design of the present invention prevents recirculation and thus minimizes carryover, chemical noise, and source turbulence and as an added benefit, enables a user to easily clean such a system during maintenance.

Abstract translation: 引入了用于防止作为离子源装置的一部分的回流的系统。 这样的系统在源内包含新颖的连续流动引导件，例如API离子源。 在喷射方向上，限定内部容积的第一部分的横截面面积首先以收敛方式减小，然后以发散方式朝向源壳体的出口开口增加。 这种流动引导件已被设计为离子源壳体的组成部分，以提供通过质谱仪入口的采样孔的最佳单向流动。 因此，本发明的新颖设计防止再循环，从而使携带，化学噪声和源湍流最小化，并且作为附加的益处，使得用户能够在维护期间容易地清洁这样的系统。