公开(公告)号：US20190211272A1

公开(公告)日：2019-07-11

申请号：US16358545

申请日：2019-03-19

Applicant: The University of Wyoming Research Corporation dba Western Research Institute

Inventor： John F. Schabron ,  Joseph F. Rovani, JR. ,  Jean-Pascal Planche

IPC: C10G25/00 ,  B01D15/26 ,  B01D15/00 ,  G01N30/46 ,  C10G53/08 ,  G01N33/28 ,  B01J20/281 ,  B01J20/286 ,  B01J20/287 ,  C10G25/12 ,  G01N30/14 ,  B01J20/284 ,  B01J20/283

CPC classification number: C10G25/003 ,  B01D15/00 ,  B01D15/265 ,  B01J20/281 ,  B01J20/283 ,  B01J20/284 ,  B01J20/286 ,  B01J20/287 ,  C10G25/12 ,  C10G53/08 ,  C10G2400/30 ,  G01N30/14 ,  G01N30/461 ,  G01N30/468 ,  G01N33/2823 ,  G01N33/2835 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/143 ,  G01N2030/8854

Abstract: A method for determining asphaltene stability in a hydrocarbon-containing material having solvated asphaltenes therein is disclosed. In at least one embodiment, it involves the steps of: (a) precipitating an amount of the asphaltenes from a liquid sample of the hydrocarbon-containing material with an alkane mobile phase solvent in a column; (b) dissolving a first amount and a second amount of the precipitated asphaltenes by changing the alkane mobile phase solvent to a final mobile phase solvent having a solubility parameter that is higher than the alkane mobile phase solvent; (c) monitoring the concentration of eluted fractions from the column; (d) creating a solubility profile of the dissolved asphaltenes in the hydrocarbon-containing material; and (e) determining one or more asphaltene stability parameters of the hydrocarbon-containing material.

公开(公告)号：US20190204278A1

公开(公告)日：2019-07-04

申请号：US16302253

申请日：2017-05-25

Applicant: SHOWA DENKO K.K.

Inventor： Hideyuki KONDO ,  Junya KATO ,  Naoko MARUOKA

IPC: B01J20/281 ,  G01N30/56 ,  G01N30/32

CPC classification number: G01N30/482 ,  G01N30/26 ,  G01N30/32 ,  G01N30/56 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/324 ,  G01N2030/484 ,  G01N2030/562

Abstract: A liquid chromatography packing material employing crosslinked polymer particles, wherein the volume average particle size of the crosslinked polymer particles is at least 2 μm but not more than 10 μm, the amount of fine particles having a particle size of 1 μm or less among the crosslinked polymer particles is less than 1% by volume, and the identity coefficient in the particle size distribution is not more than 1.15.

公开(公告)号：US10234435B2

公开(公告)日：2019-03-19

申请号：US15251553

申请日：2016-08-30

Applicant: Sunghan Jung ,  Ami Choi ,  JungDae Park ,  Dong-Soo Lee ,  Ji-Won Eom ,  Kyung-Soo Chae ,  Kwang-Shin Lim

Inventor： Sunghan Jung ,  Ami Choi ,  JungDae Park ,  Dong-Soo Lee ,  Ji-Won Eom ,  Kyung-Soo Chae ,  Kwang-Shin Lim

IPC: G01N30/64 ,  G01N30/96 ,  B01J20/281

Abstract: A conductivity detector includes a flow channel, an electrode arrangement, and a detector. The flow channel has a tube shape with a channel diameter through which a solution including ion components flows. The electrode arrangement is on the flow channel and includes at least an anode and at least a cathode. The anode and cathode are spaced apart by an electrode gap less than or equal to the channel diameter. The detector is connected to the electrode arrangement to detect electrical conductivity of the ion components.

公开(公告)号：US20190070587A1

公开(公告)日：2019-03-07

申请号：US16054949

申请日：2018-08-03

Applicant: Masoud Agah ,  Muhammad Akbar ,  Apoorva Garg ,  Leyla Nazhandali ,  Hamza Shakeel

Inventor： Masoud Agah ,  Muhammad Akbar ,  Apoorva Garg ,  Leyla Nazhandali ,  Hamza Shakeel

IPC: B01J20/32 ,  G01N30/60 ,  B01J20/22 ,  B01J20/281

Abstract: The present invention provides a detector and method for detecting substances in complex mixtures. The detector includes a microfabricated preconcentrator, a separation column with an on-chip thermal conductivity detector, a controller for controlling flow and thermal management and a user interface. The thermal conductivity detector includes a first resistor located at an inlet of the separation column and a second resistor located at an outlet of the separation column.

公开(公告)号：US10221363B2

公开(公告)日：2019-03-05

申请号：US15167766

申请日：2016-05-27

Applicant: The University of Wyoming Research Corporation

Inventor： John F. Schabron ,  Ryan B. Boysen ,  Eric W. Kalberer ,  Joseph F. Rovani, Jr.

IPC: C10G53/08 ,  C10G25/00 ,  B01D15/26 ,  C10G25/12 ,  G01N30/46 ,  G01N33/28 ,  B01J20/281 ,  B01J20/283 ,  B01J20/284 ,  B01J20/286 ,  B01J20/287 ,  B01D15/00 ,  G01N30/14 ,  G01N30/08 ,  G01N30/88 ,  G01N30/02

Abstract: The inventive technology may involve, in particular embodiments, novel use of a non-porous, high surface energy stationary phase to adsorb, in reversible fashion, the most polar component of a resins fraction of an input hydrocarbon when a mobile phase is passed over the stationary phase. Such reversible adsorption prevents irreversibly adsorption of such components on active stationary phase(s) downflow of the non-porous, high surface energy stationary phase, thereby conserving stationary phase costs and increasing resolution of resins elutions, and accuracy of hydrocarbon component results. Aspects of the inventive technology may also involve a novel combination of a solubility based asphaltene component fractionating and analysis method and an adsorption chromatography method for separating and/or analyzing saturate, aromatics and resins components of an input hydrocarbon.

公开(公告)号：US20190023736A1

公开(公告)日：2019-01-24

申请号：US16070965

申请日：2017-01-17

Applicant: ASAHI KASEI MEDICAL CO., LTD.

Inventor： Yoshiro YOKOYAMA ,  Hiroki TANIGUCHI

IPC: C07K1/18 ,  B01J39/20 ,  B01J39/05 ,  C07K16/00 ,  B01J20/281 ,  B01D15/36 ,  B01D71/26 ,  B01D71/34

Abstract: The present invention provides a method for purifying a protein, comprising: providing a solution containing a monomer and aggregates of the protein of interest; a purification step of removing the aggregates of the protein of interest using a cation-exchange chromatographic support media to obtain a purified solution of the monomer, the cation-exchange chromatographic support media comprising at least one type of weak cation-exchange group and having a cation-exchange group density higher than 30 mmol/L; and a virus removal step of removing viruses from the purified solution using a virus removal membrane having a virus logarithmic reduction value of 3 or more.

公开(公告)号：US20180369812A1

公开(公告)日：2018-12-27

申请号：US16116174

申请日：2018-08-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christoph Boehm ,  Thorsten Brueckner ,  Sascha Lutz

IPC: B01L3/00 ,  G01N30/74 ,  B01J20/281

Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.

公开(公告)号：US20180259494A1

公开(公告)日：2018-09-13

申请号：US15914428

申请日：2018-03-07

Applicant: Waters Technologies Corporation

Inventor： Dimple D. Shah ,  Jacob N. Fairchild ,  Euan Ross ,  Benjamin Wuyts

IPC: B01J20/281 ,  G01N30/74 ,  G01N30/72 ,  G01N30/86

CPC classification number: G01N30/482 ,  G01N30/72 ,  G01N30/74 ,  G01N30/8631 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/884 ,  G01N2033/184

Abstract: The present disclosure relates to the determination of pesticides, e.g., polar pesticides, in a sample using chromatography. The present disclosure can provide direct analysis of polar pesticides, including anionic polar pesticides, using high performance liquid chromatography. The polar pesticides are sufficiently retained and resolved to allow for multiple polar pesticide determinations in a single analysis.

公开(公告)号：US20180223003A1

公开(公告)日：2018-08-09

申请号：US15937428

申请日：2018-03-27

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Mattias Algotsson ,  Lars C. Andersson ,  Eggert Brekkan ,  Lee Hedemyr ,  Jean-Luc Maloisel ,  Ronnie Palmgren

IPC: C08B37/00 ,  C07C323/60 ,  C07C237/10 ,  B01J20/32 ,  B01J20/281 ,  B01J20/289

CPC classification number: C08B37/0039 ,  B01J20/281 ,  B01J20/289 ,  B01J20/3219 ,  B01J20/3251 ,  B01J20/3265 ,  C07C237/10 ,  C07C323/60

Abstract: The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification of biomolecules. Dimeric chelators offer a cooperativity of binding of two adjacent immobilized metal ions simultaneously to a histidine-tagged biomolecule, which gives advantageous properties regarding strength of binding compared to a corresponding monomer chelator. In addition, a dimer increases the selectivity (ease of separation) against non-tagged biomolecules with low metal-ion affinity.

公开(公告)号：US20180209947A1

公开(公告)日：2018-07-26

申请号：US15123307

申请日：2015-03-03

Applicant: Bioway Scientific LLC

Inventor： James Wei Xu

IPC: B01J20/281 ,  B01J20/04 ,  B01J20/28 ,  B01J20/282 ,  B01J20/30 ,  C01B25/32

CPC classification number: G01N30/482 ,  B01J20/048 ,  B01J20/28004 ,  B01J20/28011 ,  B01J20/28019 ,  B01J20/28071 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/3021 ,  B01J20/3028 ,  B01J20/3085 ,  C01B25/322

Abstract: Highly spherical sorbents of porous hydroxyapatite materials and methods of producing these sorbents are disclosed. The sorbents of the present invention have good mechanical stability and are useful as chromatography media for the separation of biomolecules, such as proteins and nucleic acids.