公开(公告)号：US20130264473A1

公开(公告)日：2013-10-10

申请号：US13993316

申请日：2011-12-14

Applicant: Alexander A. Makarov

Inventor： Alexander A. Makarov

IPC: H01J49/28

CPC classification number: H01J49/282 ,  H01J49/027 ,  H01J49/08 ,  H01J49/38 ,  H01J49/4245

Abstract: Mass analysers and methods of ion detection for a mass analyser are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.

Abstract translation: 提供了用于质量分析仪的质量分析仪和离子检测方法。 静电场发生器提供静电场，使离子包沿着一个方向振荡。 在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。 还检测到谐波瞬态信号。 然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。

公开(公告)号：US20130068942A1

公开(公告)日：2013-03-21

申请号：US13522458

申请日：2010-11-24

Applicant: Anatoly Verenchikov

Inventor： Anatoly Verenchikov

IPC: H01J49/28 ,  H01J49/40

CPC classification number: H01J49/282 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/062 ,  H01J49/40 ,  H01J49/401 ,  H01J49/406 ,  H01J49/4245

Abstract: Electrostatic trap mass spectrometers are disclosed that may comprise at least two parallel sets of electrodes separated by a field-free space, wherein said at least two parallel electrode sets extend along a curved Z-direction locally orthogonal to said X-Y plane such that each of said two electrode sets define a volume with a two-dimensional electrostatic field in an X-Y plane and define either planar or torroidal field regions; means for adjusting the torroidal field regions to provide both (i) stable trapping of ions passing between said fields within said X-Y plane and (ii) isochronous repetitive ion oscillations within said X-Y plane such that the stable ion motion does not require any orbital or side motion; and an ion bounding means in the curved Z-direction configured to compensate time-of-flight distortions at Z-edges of the trap.

Abstract translation: 公开了静电捕获质谱仪，其可以包括由无场空间分开的至少两个平行的电极组，其中所述至少两个平行电极组沿着与所述XY平面正交的局部弯曲的Z方向延伸，使得每个所述 两个电极组限定了在XY平面中具有二维静电场的体积并且限定了平面或环形场区域; 用于调节环形场区以提供（i）在所述XY平面内的所述场之间通过的离子的稳定捕获和（ii）所述XY平面内的同步重复离子振荡的装置，使得稳定的离子运动不需要任何轨道或​​侧面 运动; 并且弯曲Z方向上的离子界限装置被配置为补偿陷阱的Z边缘处的飞行时间失真。

公开(公告)号：US20130048852A1

公开(公告)日：2013-02-28

申请号：US13695388

申请日：2011-04-14

Applicant: Anatoly N. Verenchikov

Inventor： Anatoly N. Verenchikov

IPC: H01J49/28

CPC classification number: H01J49/401 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/22 ,  H01J49/40 ,  H01J49/406

Abstract: A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (E-trap) or a multi-pass TOF mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups. The method is particularly useful for tandem mass spectrometry wherein spectra are sparse. The method improves the duty cycle, the dynamic range and the space charge throughput of the analyzer and of the detector, so as the response time of the E-trap analyzer. It allows flight extension without degrading E-trap sensitivity.

Abstract translation: 公开了用于操作具有扩展飞行路径的开放式静电捕集器（E-trap）或多遍TOF质谱仪的方法，装置和算法。 采用一串具有不等时间间隔的起始脉冲来触发分析仪中的离子包注入，获取长谱以接收整个串中的离子，并通过在数据分析阶段消除或计算重叠信号来重建真实的光谱 同时使用峰值组的逻辑分析。 该方法对于其中光谱稀疏的串联质谱特别有用。 该方法提高了分析仪和检测器的占空比，动态范围和空间电荷吞吐量，以及E-trap分析仪的响应时间。 它允许飞行延长，而不会降低E-trap灵敏度。

公开(公告)号：US08319177B2

公开(公告)日：2012-11-27

申请号：US12774869

申请日：2010-05-06

Applicant: Paul Boyle ,  Andrew H. Koehl ,  David Ruiz-Alonso

Inventor： Paul Boyle ,  Andrew H. Koehl ,  David Ruiz-Alonso

IPC: H01J49/28

CPC classification number: G01N27/624

Abstract: An ion mobility spectrometer is described having an ion filter in the form of at least one ion channel having a plurality of electrodes. A time-varying electric potential applied to the conductive layers allows the filler to selectively admit ion species. The electric potential has a drive and a transverse component, and in preferred embodiments each of the electrodes is involved in generating a component of both the drive and transverse fields. The device may be used without a drift gas flow. Microfabrication techniques are described for producing microscale spectrometers, as are various uses of the spectrometer.

Abstract translation: 描述了一种离子迁移谱仪，其具有至少一个具有多个电极的离子通道形式的离子过滤器。 施加到导电层的时变电位允许填料选择性地允许离子种类。 电位具有驱动和横向分量，并且在优选实施例中，每个电极参与产生驱动和横向场的分量。 该装置可以在没有漂移气流的情况下使用。 描述了用于生产微量光谱仪的微加工技术，以及光谱仪的各种用途。

公开(公告)号：US20110133075A1

公开(公告)日：2011-06-09

申请号：US13058054

申请日：2009-08-25

Applicant: Yuichiro Hashimoto ,  Hideki Hasegawa ,  Masuyuki Sugiyama

Inventor： Yuichiro Hashimoto ,  Hideki Hasegawa ,  Masuyuki Sugiyama

IPC: H01J49/26 ,  H01J49/34 ,  H01J49/28 ,  H01J49/10 ,  B01D59/46

CPC classification number: H01J49/4225

Abstract: The mass spectrometer is characterized in that a linear ion trap, that consists of electrodes for mass-selective discharge, is provided with a mechanism that excites ions in a first direction that is perpendicular to the rod axes and a mechanism that simultaneously generates an electric field on the axes in a second direction that is perpendicular to the axial direction and the first direction in order to generate an electric field on the central axis. Highly efficient, high-speed scanning can be achieved using this configuration.

Abstract translation: 质谱仪的特征在于，由用于质量选择性放电的电极组成的线性离子阱设置有在垂直于杆轴的第一方向上激发离子的机构和同时产生电场的机构 在垂直于轴向方向和第一方向的第二方向上的轴上，以便在中心轴线上产生电场。 使用此配置可​​以实现高效，高速扫描。

公开(公告)号：US20100065738A1

公开(公告)日：2010-03-18

申请号：US12506605

申请日：2009-07-21

Applicant: Andrew BOWDLER

Inventor： Andrew BOWDLER

IPC: H01J49/28 ,  H01J49/26

CPC classification number: H01J49/40 ,  H01J49/06 ,  H01J49/067

Abstract: The present invention provides a mass spectrometer including an ion source for generating pre-cursor ions, ion fragmentation means for generating fragment ions from the pre-cursor ions, a reflectron for focusing the kinetic energy distribution of the ions, and an ion detector wherein the mass spectrometer also includes axial spatial distribution focusing means which in use acts on the ions after the ion fragmentation means and before the reflectron, the axial spatial distribution focusing means being operable to reduce the spatial distribution of the ions in the direction of the ion optical axis of the spectrometer. Suitably the axial spatial distribution focusing means comprising a cell with two electrodes 52, 54 which may be apertures or high transmission grids. A pulsed electrostatic field is generated by applying a high voltage pulse 60 to the first electrode 52 at the time when the pre-cursor ions of interest 56, 58 have just passed into the pulser 50. The second electrode 54 is maintained at 0V during this time.

Abstract translation: 本发明提供了一种质谱仪，其包括用于产生前体离子的离子源，用于从前体离子产生碎片离子的离子碎裂装置，用于聚焦离子的动能分布的反射器，以及离子检测器，其中 质谱仪还包括轴向空间分布聚焦装置，其在使用中作用于离子碎片装置之后的离子并且在反射体之前，轴向空间分布聚焦装置可操作以减少离子在离子光轴方向上的空间分布 的光谱仪。 适当地，轴向空间分布聚焦装置包括具有两个电极52,54的单元，其可以是孔或高传输格栅。 当感兴趣的前置离子56,58刚刚进入脉冲发生器50时，通过将高电压脉冲60施加到第一电极52来产生脉冲静电场。在此期间，第二电极54保持在0V 时间。

公开(公告)号：US20080272293A1

公开(公告)日：2008-11-06

申请号：US11742693

申请日：2007-05-01

Applicant: Marvin L. Vestal

Inventor： Marvin L. Vestal

IPC: H01J49/28 ,  H01J49/16 ,  H01J49/02

CPC classification number: H01J49/164 ,  H01J49/406

Abstract: The TOF mass spectrometer disclosed places an even number of ion mirrors in close proximity to a MALDI ion source and a field-free drift space between the exit from the mirrors and an ion detector. This “reversed geometry” configuration may be distinguished from a conventional reflecting TOF analyzer employing a single ion mirror where a large fraction of the total drift space is located between the ion source and the mirror.

Abstract translation: 所公开的TOF质谱仪将偶数数量的离子反射镜靠近MALDI离子源和从反射镜出口和离子检测器之间的无场漂移空间。 这种“反转几何”配置可以与使用单个离子镜的常规反射TOF分析仪区分开，其中大部分总漂移空间位于离子源和反射镜之间。

公开(公告)号：US20080272289A1

公开(公告)日：2008-11-06

申请号：US11742685

申请日：2007-05-01

Applicant: Marvin L. Vestal

Inventor： Marvin L. Vestal

IPC: H01J49/28 ,  H01J49/16

CPC classification number: H01J49/164 ,  H01J49/025 ,  H01J49/40

Abstract: The present invention provides a time-of-flight (TOF) mass analyzer. The system includes an analyzer vacuum housing isolated from the evacuated ion source vacuum housing by a gate valve maintained at ground potential. A pulsed ion source is located within the ion source housing, and the gate valve is located in a first field-free region at ground potential. A second field-free drift space within the analyzer housing is biased at high voltage with opposite polarity to the voltage applied to the pulsed ion source. Novel ion detectors are provided with input surfaces in electrical contact with the second field-free drift space with output connected to an external digitizer at ground potential.

Abstract translation: 本发明提供了飞行时间（TOF）质量分析仪。 该系统包括通过保持在地电位的闸阀与真空离子源真空壳体隔离的分析器真空壳体。 脉冲离子源位于离子源壳体内，闸阀位于地电势的第一无场区域。 分析仪外壳内的第二无场漂移空间以与施加到脉冲离子源的电压极性相反的高电压偏置。 新型离子检测器设置有与第二无场漂移空间电接触的输入表面，其输出连接到地电位的外部数字化仪。

公开(公告)号：US07439498B2

公开(公告)日：2008-10-21

申请号：US11260663

申请日：2005-10-28

Applicant: Albert Edward Litherland ,  Jonathan P. Doupe ,  William Edward Kieser ,  Xiao-Lei Zhao ,  Gholamreza Javahery ,  Lisa Cousins ,  Ilia Tomski ,  Charles Jolliffe

Inventor： Albert Edward Litherland ,  Jonathan P. Doupe ,  William Edward Kieser ,  Xiao-Lei Zhao ,  Gholamreza Javahery ,  Lisa Cousins ,  Ilia Tomski ,  Charles Jolliffe

IPC: H01J49/40 ,  H01J49/28

CPC classification number: H01J49/0086 ,  B01D59/44 ,  H01J49/0077 ,  H01J49/06

Abstract: This invention relates to a method and apparatus for separation of rare stable or radioactive isotopes from their atomic or molecular isobars in mass spectrometry (MS). In the present invention, the approach taken to removing atomic isobars utilizes a high transmission device for decelerating ions in combination with low energy reactions, such as ion-molecule reactions or near resonant electron transfer, in RF ion guides. The isobar is selectively depleted by electron transfer or other reactions between negative ions and gaseous targets in pressurized RF ion guides at low energies. The energy is controlled in such a way as to prevent reaction of the ion of interest while inducing reactions with the undesired isobar interference. The technique is of particular relevance to accelerator mass spectrometry (AMS) for which it allows substantial reductions in the necessary terminal voltage. The effect is to allow reductions in the size and cost of AMS installations.

Abstract translation: 本发明涉及在质谱（MS）中从其原子或分子等值线分离稀有稳定或放射性同位素的方法和装置。 在本发明中，用于除去原子等压线的方法利用高传输装置，用于在RF离子导向器中结合低能量反应（例如离子分子反应或接近谐振电子转移）来减速离子。 在低能量下，加压RF离子导向器中的等离子体被电子转移或负离子与气态靶之间的其它反应选择性地耗尽。 控制能量以防止感兴趣的离子的反应，同时诱导与不期望的等压线干涉的反应。 该技术与加速器质谱（AMS）特别相关，其能够显着降低必需的终端电压。 其效果是可以减少AMS安装的尺寸和成本。

公开(公告)号：US20060226355A1

公开(公告)日：2006-10-12

申请号：US11375063

申请日：2006-03-15

Applicant: Fumio Watanabe ,  Reiki Watanabe

Inventor： Fumio Watanabe ,  Reiki Watanabe

IPC: H01J49/28

CPC classification number: H01J49/147 ,  H01J41/10 ,  H01J49/4215

Abstract: In a quadrupole mass spectrometer which measures partial pressure strength according to a gas type in a vacuum system from ion current intensity, a quadrupole mass spectrometer with a total pressure measurement electrode has a total pressure measurement electrode for examining an ion density disposed in a demarcation space which is comprised of a grid electrode and an ion focusing electrode. And, a vacuum system is provided with only the quadrupole mass spectrometer which measures partial pressure strength according to a gas type in the vacuum system from an ion current intensity and does not have an ionization vacuum gauge other than the quadrupole mass spectrometer.

Abstract translation: 在根据离子电流强度根据真空系统中的气体类型测量分压强度的四极杆质谱仪中，具有总压力测量电极的四极质谱仪具有用于检查设置在分界空间中的离子密度的总压力测量电极 其由栅电极和离子聚焦电极组成。 并且，仅具有四极质谱仪的真空系统，该四极质谱仪根据离子电流强度根据真空系统中的气体类型测量分压强度，并且除四极质谱仪之外不具有电离真空计。