公开(公告)号：US20240234115A1

公开(公告)日：2024-07-11

申请号：US18151321

申请日：2023-01-06

Applicant: THERMO FINNIGAN LLC

Inventor： Paul R. Gazis

IPC: H01J49/00 ,  G01N33/68 ,  H01J49/02 ,  H01J49/16

CPC classification number: H01J49/0036 ,  G01N33/6848 ,  H01J49/025 ,  H01J49/165

Abstract: A mass spectrometry method comprises: identifying groups of charge state distributions (CSDs) within deconvoluted mass spectrometric data, wherein CSDs of each group comprise at least one common mass spectral peak that is assigned a different respective charge state within each CSD of each group; assigning, within each group, a respective weighting factor to each CSD; calculating, within each group and using the weighting factors, a score-weighted average molecular weight for each compound CSD; locating, within each group, a single target CSD that that corresponds to a molecular weight that is closest to the calculated average; for each common peak of each identified group, summing the intensities of the respective common assigned mass spectral peak across the group and assigning the summed intensity to the single target CSD of the group; discarding all CSDs other than the target CSDs; and calculating an abundance of each component compound using the summed intensities.

公开(公告)号：US11967495B2

公开(公告)日：2024-04-23

申请号：US17544599

申请日：2021-12-07

Applicant: Leidoc, Inc.

Inventor： Noah Peter Christian

IPC: H01J49/00 ,  H01J49/02 ,  H01J49/06 ,  H01J49/16 ,  H01J49/20 ,  H01J49/24 ,  H01J49/30

CPC classification number: H01J49/004 ,  H01J49/025 ,  H01J49/067 ,  H01J49/16 ,  H01J49/20 ,  H01J49/24 ,  H01J49/0013 ,  H01J49/30

Abstract: A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.

公开(公告)号：US11923182B2

公开(公告)日：2024-03-05

申请号：US17053506

申请日：2019-04-08

Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (GMBH) ,  Photonion GMBH

Inventor： Ralf Zimmermann ,  Johannes Passig ,  Sven Ehlert

IPC: H01J49/00 ,  H01J49/02 ,  H01J49/04 ,  H01J49/16

CPC classification number: H01J49/0463 ,  H01J49/0031 ,  H01J49/0095 ,  H01J49/025 ,  H01J49/162 ,  H01J49/164

Abstract: Devices and methods for mass spectroscopic analysis of particles are disclosed herein. An example device includes: a first irradiation unit configured to irradiate a particle with electromagnetic radiation to cause components of the particle to detach from the particle. The example device further includes a second irradiation unit configured to irradiate substantially simultaneously i) at least a part of the detached components, and optionally a residual core of the particle, with a first beam of electromagnetic radiation the first beam of electromagnetic radiation exhibiting a first intensity, and ii) at least a part of the residual core, of the particle with a second beam of electromagnetic radiation. The second beam of electromagnetic radiation exhibiting a second intensity, which is preferably larger than the first intensity. The example device further includes a mass spectrometer comprising an ion source region, a first detection channel, and optionally a second detection channel.

公开(公告)号：US20240071742A1

公开(公告)日：2024-02-29

申请号：US18455356

申请日：2023-08-24

Applicant: Thermo Finnigan LLC

Inventor： Christopher Mullen ,  John Syka

IPC: H01J49/42 ,  H01J49/02

CPC classification number: H01J49/429 ,  H01J49/025 ,  H01J49/4225

Abstract: This system and method disclosed herein are configured to improve high mass range ion trap performance by use of a multi-directional segmented scan approach. In some embodiments of the system and method disclosed herein, the mass range of conventional ion trap technology may be extended/increased without changing the hardware or compromising lower range mass/charge efficiency. Specifically, the system and methods disclosed herein use a segmented, bi-directional scan that increases the mass range of an ion trap mass spectrometer and circumvents the problem of mass discrimination during mass analysis in the high Thompson value range.

公开(公告)号：US11867700B2

公开(公告)日：2024-01-09

申请号：US18298514

申请日：2023-04-11

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Martin F. Jarrold ,  Corrine A. Lutomski

IPC: G01N33/68 ,  G01N33/92 ,  H01J49/42 ,  H01J49/00 ,  H01J49/02 ,  H01J49/40

CPC classification number: G01N33/6848 ,  G01N33/92 ,  H01J49/0068 ,  H01J49/025 ,  H01J49/40 ,  H01J49/4225

Abstract: The present disclosure relates to methods of identifying components present in intact lipoprotein particles. Methods provided include single particle mass spectrometry, such as charge detection mass spectrometry (CDMS). Distinct subtypes and subpopulations that exist within lipoprotein density classes are determined based on simultaneously measured m/z and charge of ionized lipoprotein particles.

公开(公告)号：US11846736B2

公开(公告)日：2023-12-19

申请号：US17617277

申请日：2019-07-10

Applicant: Hitachi High-Tech Corporation

Inventor： Eri Takahashi ,  Shin Imamura ,  Makoto Suzuki ,  Shunsuke Mizutani

IPC: G01T1/202 ,  H01J37/244 ,  H01J49/02 ,  H01J37/28 ,  H01J49/26

CPC classification number: G01T1/2023 ,  H01J37/244 ,  H01J49/025 ,  H01J37/28 ,  H01J49/26 ,  H01J2237/2443 ,  H01J2237/2448 ,  H01J2237/2803

Abstract: The purpose of the present invention is to provide a scintillator for a charged particle beam device and a charged particle beam device which achieve both an increase in emission intensity and a reduction in afterglow intensity. This scintillator for a charged particle beam device is characterized by comprising a substrate (13), a buffer layer (14) formed on a surface of the substrate (13), a stack (12) of a light emitting layer (15) and a barrier layer (16) formed on a surface of the buffer layer (14), and a conductive layer (17) formed on a surface of the stack (12) and by being configured such that the light emitting layer (15) contains InGaN, the barrier layer (16) contains GaN, and the ratio b/a of the thickness b of the barrier layer (16) to the thickness a of the light emitting layer (15) is 11 to 25.

公开(公告)号：US11728154B2

公开(公告)日：2023-08-15

申请号：US17535452

申请日：2021-11-24

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Peter Komander ,  Heinz Lerche

IPC: H01J49/02 ,  H01J49/26 ,  H03F3/04 ,  G01T1/24

CPC classification number: H01J49/022 ,  G01T1/247 ,  H01J49/025 ,  H01J49/26 ,  H03F3/04

Abstract: An ion detection current conversion circuit includes a conversion amplifier coupled with a conversion resistor assembly for converting an ion detection current produced by an ion detector into an ion detection voltage, the conversion resistor assembly comprising a resistor having a high resistance and a capacitive compensation element, and a compensation voltage circuit for deriving a compensation voltage from the ion detection voltage and feeding the compensation voltage to the capacitive compensation element, the compensation voltage circuit comprising a variable resistor for adjusting the compensation voltage.

公开(公告)号：US20230243846A1

公开(公告)日：2023-08-03

申请号：US18298514

申请日：2023-04-11

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Martin F. JARROLD ,  Corrine A. LUTOMSKI

IPC: G01N33/68 ,  G01N33/92 ,  H01J49/00 ,  H01J49/02 ,  H01J49/40 ,  H01J49/42

CPC classification number: G01N33/6848 ,  G01N33/92 ,  H01J49/0068 ,  H01J49/025 ,  H01J49/40 ,  H01J49/4225

Abstract: The present disclosure relates to methods of identifying components present in intact lipoprotein particles. Methods provided include single particle mass spectrometry, such as charge detection mass spectrometry (CDMS). Distinct subtypes and subpopulations that exist within lipoprotein density classes are determined based on simultaneously measured m/z and charge of ionized lipoprotein particles.

公开(公告)号：US11710627B2

公开(公告)日：2023-07-25

申请号：US17558925

申请日：2021-12-22

Applicant: Micromass UK Limited

Inventor： Emrys Jones ,  Steven Derek Pringle ,  Keith Richardson ,  James Ian Langridge ,  Zoltan Takats

IPC: G01N30/72 ,  H01J49/04 ,  A61B10/02 ,  A61B18/00 ,  A61B18/14 ,  A61B18/20 ,  G01N3/00 ,  G01N9/00 ,  G01N33/68 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  G16B20/50 ,  G01N27/623 ,  A61B90/13 ,  A61B1/04 ,  A61B1/273 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/055 ,  A61B6/03 ,  A61B8/13 ,  A61B10/00 ,  A61B17/00 ,  A61B18/04 ,  A61B18/18 ,  A61F13/38 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/22 ,  G01N27/624 ,  G01N33/487 ,  G01N33/92 ,  H01J49/02 ,  H01J49/10 ,  H01J49/14 ,  H01J49/24 ,  H01J49/26 ,  G16B20/00 ,  A61B17/32 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  A61B1/00 ,  A61B1/31 ,  A61B5/145

CPC classification number: H01J49/049 ,  A61B1/041 ,  A61B1/2736 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/055 ,  A61B5/0507 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B18/00 ,  A61B18/04 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/623 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G16B20/50 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/044 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26 ,  A61B1/00013 ,  A61B1/31 ,  A61B5/14542 ,  A61B17/320068 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00994 ,  A61B2218/002 ,  A61B2218/008 ,  G01N33/48735 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G16B20/00 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20

Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

公开(公告)号：US20180308674A1

公开(公告)日：2018-10-25

申请号：US15752871

申请日：2016-08-11

Applicant: Thermo Fisher Scientific (Bremen) GmbH ,  The University of Bristol

Inventor： Johannes SCHWIETERS ,  Timothy Richard ELLIOTT ,  Christopher David COATH

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/10

CPC classification number: H01J49/025 ,  H01J49/0045 ,  H01J49/105 ,  H01J49/28

Abstract: The present invention can be directed to a mass spectrometer, relevant parts thereof like replacement kits or upgrading kits and/or mass spectrometry methods. A mass spectrometer according to the present invention can comprise at least one ion source for generating a beam of ions from a sample. Moreover at least one mass filter downstream of the ion source can be provided and adapted to select ions from the beam by their mass-to-charge ratio (m/z). Furthermore at least one collision cell arranged downstream of the mass filter can be arranged. At least one sector field mass analyser arranged downstream of the collision cell can be further provided and at least one ion multicollector comprising a plurality of ion detectors arranged downstream of the mass analyser, for detecting a plurality of different ion species in parallel and/or simultaneously.