公开(公告)号：US20170365456A1

公开(公告)日：2017-12-21

申请号：US15695969

申请日：2017-09-05

Applicant: LECO Corporation

Inventor： Anatoly N. Verenchikov

IPC: H01J49/28 ,  H01J49/06 ,  H01J49/00 ,  H01J49/42 ,  H01J49/40

CPC classification number: H01J49/282 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/062 ,  H01J49/40 ,  H01J49/401 ,  H01J49/406 ,  H01J49/4245

Abstract: An apparatus 41 and operation method are provided for an electrostatic trap mass spectrometer with measuring frequency of multiple isochronous ionic oscillations. For improving throughput and space charge capacity, the trap is substantially extended in one Z-direction forming a reproduced two-dimensional field. Multiple geometries are provided for trap Z-extension. The throughput of the analysis is improved by multiplexing electrostatic traps. The frequency analysis is accelerated by the shortening of ion packets and either by Wavelet-fit analysis of the image current signal or by using a time-of-flight detector for sampling a small portion of ions per oscillation. Multiple pulsed converters are suggested for optimal ion injection into electrostatic traps.

公开(公告)号：US09548195B2

公开(公告)日：2017-01-17

申请号：US15093152

申请日：2016-04-07

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Christian Albrecht Hock ,  Dmitry Grinfeld ,  Richard Heming

IPC: H01J49/00 ,  H01J49/42 ,  H01J49/04 ,  H01J49/06 ,  H01J49/28 ,  H01J49/40

CPC classification number: H01J49/427 ,  H01J49/0031 ,  H01J49/0481 ,  H01J49/063 ,  H01J49/282 ,  H01J49/40 ,  H01J49/4225 ,  H01J49/424 ,  H01J49/4245

Abstract: A method of ejecting ions to be analyzed from a quadrupole ion trap in which a trapping field is created by one or more RF voltages applied to one or more electrodes of the trap, the method comprising the steps of cooling the ions to be analyzed within the quadrupole ion trap until the ions are thermalized, reducing the amplitude of one or more RF voltages applied to the quadrupole ion trap and applying the reduced amplitude RF voltages for one half cycle after the one or more RF voltages have reached a zero crossing point, turning off the RF voltages applied to the quadrupole ion trap, and ejecting the ions to be analyzed from the quadrupole ion trap.

Abstract translation: 从四极离子阱中排出要分析的离子的方法，其中通过施加到阱的一个或多个电极的一个或多个RF电压产生捕获场，该方法包括以下步骤：将待分析的离子冷却在 四极离子阱，直到离子被热化，减少施加到四极离子阱的一个或多个RF电压的幅度，并且在一个或多个RF电压已经达到过零点之后将减小幅度的RF电压施加一个半周期，转动 关闭施加到四极离子阱的RF电压，并从四极离子阱中喷射待分析的离子。

公开(公告)号：US09437412B2

公开(公告)日：2016-09-06

申请号：US14801642

申请日：2015-07-16

Applicant: Thermo Finnigan LLC

Inventor： Alexander Alekseevich Makarov

IPC: H01J49/00 ,  H01J49/28 ,  H01J49/42 ,  H01J49/22

CPC classification number: H01J49/282 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/22 ,  H01J49/424 ,  H01J49/425

Abstract: This invention relates generally to multi-reflection electrostatic systems, and more particularly to improvements in and relating to the Orbitrap electrostatic ion trap. A method of operating an electrostatic ion trapping device having an array of electrodes operable to mimic a single electrode is proposed, the method comprising determining three or more different voltages that, when applied to respective electrodes of the plurality of electrodes, generate an electrostatic trapping field that approximates the field that would be generated by applying a voltage to the single electrode, and applying the three or more so determined voltages to the respective electrodes. Further improvements lie in measuring a plurality of features from peaks with different intensities from one or more collected mass spectra to derive characteristics, and using the measured characteristics to improve the voltages to be applied to the plurality of electrodes.

公开(公告)号：US20160240363A1

公开(公告)日：2016-08-18

申请号：US15087534

申请日：2016-03-31

Applicant: LECO Corporation

Inventor： Anatoly N. Verenchikov

IPC: H01J49/40 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/406 ,  H01J49/0036 ,  H01J49/06 ,  H01J49/282 ,  H01J49/40 ,  H01J49/401 ,  H01J49/4245 ,  H01J49/48

Abstract: An open electrostatic trap mass spectrometer is disclosed for operation with wide and diverging ion packets. Signal on detector is composed of signals corresponding to multiplicity of ion cycles, called multiplets. Using reproducible distribution of relative intensity within multiplets, the signal can be unscrambled for relatively sparse spectra, such as spectra past fragmentation cell of tandem mass spectrometer, past ion mobility and differential ion mobility separators. Various embodiments are provided for particular pulsed ion sources and pulsed converters such as orthogonal accelerators, ion guides, and ion traps. The method and apparatus enhance the duty cycle of pulsed converters, improve space charge tolerance of the open trap analyzer and extends the dynamic range of time-of-flight detectors.

公开(公告)号：US20160005584A1

公开(公告)日：2016-01-07

申请号：US14795453

申请日：2015-07-09

Applicant: LECO Corporation

Inventor： Anatoly N. Verenchikov

IPC: H01J49/28 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/282 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/062 ,  H01J49/40 ,  H01J49/401 ,  H01J49/406 ,  H01J49/4245

Abstract: An electrostatic mass spectrometer and a method of mass spectrometric analysis utilizing novel traps are disclosed. The mass spectrometer includes an ion source, an ion pulse injector, an ion detector, a set of analyzer electrodes connected to a set of power supplies, and a vacuum chamber enclosing the set of analyzer electrodes. The analyzer electrodes have multiple sets of elongated slits forming an array of elongated volumes. Each elongated volume is formed by a single set of slits aligned between the electrodes, and each volume forms a two-dimensional electrostatic field in an X-Y plane and is extended in a locally orthogonal Z-direction. Each two-dimensional field is arranged to trap moving ions in the X-Y plane and to enable isochronous ion motion along a mean ion trajectory within the X-Y plane.

Abstract translation: 公开了静电质谱仪和利用新型捕集阱的质谱分析方法。 质谱仪包括离子源，离子脉冲注入器，离子检测器，连接到一组电源的一组分析器电极，以及包围该组分析器电极的真空室。 分析器电极具有形成细长体积阵列的多组细长狭缝。 每个细长体积由在电极之间排列的单组狭缝形成，并且每个体积在X-Y平面中形成二维静电场，并在局部正交的Z方向上延伸。 每个二维场布置成捕获X-Y平面中的移动离子，并使得能够沿着X-Y平面内的平均离子轨迹进行同步离子运动。

公开(公告)号：US09190254B1

公开(公告)日：2015-11-17

申请号：US14570529

申请日：2014-12-15

Applicant: UNIVERSITY OF NORTHERN IOWA RESEARCH FOUNDATION

Inventor： Curtiss Dwight Hanson

IPC: B01D59/46 ,  B01D59/44 ,  H01J49/28 ,  H01J49/00 ,  H01J49/06 ,  H01J49/10 ,  H01J9/14

CPC classification number: H01J49/065 ,  H01J9/14 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/10 ,  H01J49/282 ,  H01J49/42 ,  H01J49/4225 ,  H01J49/4235 ,  H01J49/425

Abstract: In one aspect of the invention, an ion trap mass analyzer includes a variable- or multi-potential type ion guide (MPIG) assembly which has been pre-configured to produce a parabolic-type potential field. Each MPIG electrode has a resistive coating of designed characteristics. In one example the coating varies in thickness along the length of an underlying uniform substrate. The MPIG assembly can be a single MPIG electrode or an array of a plurality of MPIG electrodes. An array can facilitate delocalization for improved performance. This chemical modification of a uniform underlying substrate promotes cheaper and flexible instruments. The modified MPIG electrodes also allow miniaturization (e.g. micro and perhaps even nano-scale), which allows miniaturization of the instrument in which the single or plural modified MPIG electrode(s) are placed. This promotes portability and field use instead of limitation to laboratory settings.

Abstract translation: 在本发明的一个方面，离子阱质量分析器包括已经预配置成产生抛物线型电场的可变或多电位型离子导向器（MPIG）组件。 每个MPIG电极具有设计特性的电阻涂层。 在一个实例中，涂层沿着下面的均匀基底的长度的厚度变化。 MPIG组件可以是单个MPIG电极或多个MPIG电极的阵列。 阵列可以促进离域化以提高性能。 统一的底层衬底的这种化学改性促进了便宜和灵活的仪器。 改进的MPIG电极还允许小型化（例如微量甚至是纳米尺度），这允许其中放置单个或多个修改的MPIG电极的仪器的小型化。 这促进了可移植性和现场使用，而不是限于实验室设置。

公开(公告)号：US20130056627A1

公开(公告)日：2013-03-07

申请号：US13582535

申请日：2010-12-30

Applicant: Anatoly Verenchikov

Inventor： Anatoly Verenchikov

IPC: H01J49/40

CPC classification number: H01J49/406 ,  H01J49/0036 ,  H01J49/06 ,  H01J49/282 ,  H01J49/40 ,  H01J49/401 ,  H01J49/4245 ,  H01J49/48

Abstract: An open electrostatic trap mass spectrometer is disclosed for operation with wide and diverging ion packets. Signal on detector is composed of signals corresponding to multiplicity of ion cycles, called multiplets. Using reproducible distribution of relative intensity within multiplets, the signal can be unscrambled for relatively sparse spectra, such as spectra past fragmentation cell of tandem mass spectrometer, past ion mobility and differential ion mobility separators. Various embodiments are provided for particular pulsed ion sources and pulsed converters such as orthogonal accelerators, ion guides, and ion traps. The method and apparatus enhance the duty cycle of pulsed converters, improve space charge tolerance of the open trap analyzer and extends the dynamic range of time-of-flight detectors.

Abstract translation: 公开了一种开放的静电阱质谱仪用于具有宽而分散的离子包的操作。 检测器上的信号由对应于多个离子循环的信号组成，称为多重点。 使用多重相关强度的可重复分布，对于相对稀疏的光谱，例如串联质谱仪过去的碎片单元，过去的离子迁移率和差分离子迁移分离器，信号可以被解扰。 针对特定脉冲离子源和诸如正交加速器，离子导向器和离子阱的脉冲转换器提供了各种实施例。 该方法和装置增强了脉冲转换器的占空比，提高了开路阱分析仪的空间电容容限，并扩展了飞行时间探测器的动态范围。

公开(公告)号：US20100258714A1

公开(公告)日：2010-10-14

申请号：US12820889

申请日：2010-06-22

Applicant: Alexander Alekseevich MAKAROV

Inventor： Alexander Alekseevich MAKAROV

IPC: H01J49/26 ,  H01J49/02

CPC classification number: H01J49/282 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/22 ,  H01J49/424 ,  H01J49/425

Abstract: This invention relates generally to multi-reflection electrostatic systems, and more particularly to improvements in and relating to the Orbitrap electrostatic ion trap. A method of operating an electrostatic ion trapping device having an array of electrodes operable to mimic a single electrode is proposed, the method comprising determining three or more different voltages that, when applied to respective electrodes of the plurality of electrodes, generate an electrostatic trapping field that approximates the field that would be generated by applying a voltage to the single electrode, and applying the three or more so determined voltages to the respective electrodes. Further improvements lie in measuring a plurality of features from peaks with different intensities from one or more collected mass spectra to derive characteristics, and using the measured characteristics to improve the voltages to be applied to the plurality of electrodes.

Abstract translation: 本发明一般涉及多反射静电系统，更具体地涉及Orbitrap静电离子阱的改进和涉及。 提出了一种操作具有可操作以模拟单个电极的电极阵列的静电离子捕获装置的方法，所述方法包括确定当施加到多个电极的各个电极时产生静电捕获场的三个或更多个不同的电压 其近似于将通过向单个电极施加电压而产生的场，以及将三个或更多个如此确定的电压施加到各个电极。 进一步的改进在于从具有不同强度的峰与一个或多个收集的质谱测量多个特征以导出特性，并且使用测量的特性来改善施加到多个电极的电压。

公开(公告)号：US07767960B2

公开(公告)日：2010-08-03

申请号：US11994095

申请日：2006-06-27

Applicant: Alexander Alekseevich Makarov

Inventor： Alexander Alekseevich Makarov

IPC: B01D59/44

CPC classification number: H01J49/282 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/22 ,  H01J49/424 ,  H01J49/425

Abstract: This invention relates generally to multi-reflection electrostatic systems, and more particularly to improvements in and relating to the Orbitrap electrostatic ion trap. A method of operating an electrostatic ion trapping device having an array of electrodes operable to mimic a single electrode is proposed, the method comprising determining three or more different voltages that, when applied to respective electrodes of the plurality of electrodes, generate an electrostatic trapping field that approximates the field that would be generated by applying a voltage to the single electrode, and applying the three or more so determined voltages to the respective electrodes. Further improvements lie in measuring a plurality of features from peaks with different intensities from one or more collected mass spectra to derive characteristics, and using the measured characteristics to improve the voltages to be applied to the plurality of electrodes.

Abstract translation: 本发明一般涉及多反射静电系统，更具体地涉及Orbitrap静电离子阱的改进和涉及。 提出了一种操作具有可操作以模拟单个电极的电极阵列的静电离子捕获装置的方法，所述方法包括确定当施加到多个电极的各个电极时产生静电捕获场的三个或更多个不同的电压 其近似于将通过向单个电极施加电压而产生的场，以及将三个或更多个如此确定的电压施加到各个电极。 进一步的改进在于从具有不同强度的峰与一个或多个收集的质谱测量多个特征以导出特性，并且使用测量的特性来改善施加到多个电极的电压。

公开(公告)号：US20080128613A1

公开(公告)日：2008-06-05

申请号：US11818913

申请日：2007-06-15

Applicant: Sidney E. Buttrill

Inventor： Sidney E. Buttrill

IPC: H01J49/40

CPC classification number: H01J49/282 ,  H01J49/408

Abstract: The invention provides apparatus and methods for performing time-of-flight (TOF) mass spectrometry. A TOF mass spectrometer of the present invention comprises one or more ion focusing electric sectors. At least one of the electric sectors is associated with an ion optical element. The ion optical elements comprise at least one adjustable electrode, such that the adjustable electrode is able to modify the potential experienced by an ion entering or exiting the electric sector with which it is associated.

Abstract translation: 本发明提供了用于执行飞行时间（TOF）质谱的装置和方法。 本发明的TOF质谱仪包括一个或多个离子聚焦电扇区。 电扇区中的至少一个与离子光学元件相关联。 离子光学元件包括至少一个可调电极，使得可调节电极能够改变进入或离开与其相关联的电扇区的离子所经历的电位。