公开(公告)号：US20100175994A1

公开(公告)日：2010-07-15

申请号：US12555188

申请日：2009-09-08

Applicant: Jung-nam LEE ,  Beom-seok LEE ,  Jae-chan PARK ,  Jeong-gun LEE

Inventor： Jung-nam LEE ,  Beom-seok LEE ,  Jae-chan PARK ,  Jeong-gun LEE

IPC: G01N27/333

CPC classification number: B01L3/502753 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/0409 ,  B01L2400/0677 ,  G01N27/333 ,  G01N33/4915

Abstract: Provided is a rotatable disc-shaped microfluidic device which can electrochemically detect electrolytes comprised in a specimen. The microfluidic device including: a specimen chamber which accommodates a specimen; a detection chamber which receives the specimen from the specimen chamber; and an ion sensor which is formed in the detection chamber to electrochemically detect electrolytes in the specimen and includes an indicator electrode, a standard electrode and an ion selective film formed on a portion of the indicator electrode. The standard specimen is accommodated in the detection chamber, and a standard potential is measured. Then, the specimen is accommodated in the detection chamber, and a measurement potential is obtained to detect the concentration of the electrolytes comprised in the specimen.

公开(公告)号：US20100175993A1

公开(公告)日：2010-07-15

申请号：US12555187

申请日：2009-09-08

Applicant: Jung-nam LEE ,  Beom-seok LEE ,  Jae-chan PARK ,  Jeong-gun LEE

Inventor： Jung-nam LEE ,  Beom-seok LEE ,  Jae-chan PARK ,  Jeong-gun LEE

IPC: G01N27/26

CPC classification number: B01L3/502753 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/0409 ,  B01L2400/0677 ,  G01N27/333 ,  G01N33/4915

Abstract: Provided is a rotatable disc-shaped microfluidic device which can electrochemically detect electrolytes comprised in a specimen. The microfluidic device including: a specimen chamber which accommodates a specimen; a detection chamber which receives the specimen from the specimen chamber; and an ion sensor which is formed in the detection chamber to electrochemically detect electrolytes in the specimen and includes an indicator electrode, a standard electrode and an ion selective film formed on a portion of the indicator electrode. The standard specimen is accommodated in the detection chamber, and a standard potential is measured. Then, the specimen is accommodated in the detection chamber, and a measurement potential is obtained to detect the concentration of the electrolytes comprised in the specimen.

Abstract translation: 提供了一种可旋转的盘形微流体装置，其可以电化学地检测包含在样品中的电解质。 所述微流体装置包括：容纳样本的样本室; 检测室，其从所述样本室接收所述样本; 以及离子传感器，其形成在所述检测室中以电化学检测所述检体中的电解质，并且包括在所述指示电极的一部分上形成的指示电极，标准电极和离子选择膜。 将标准样品容纳在检测室中，并测量标准电位。 然后，将样本容纳在检测室中，并且获得测量电位以检测包含在样品中的电解质的浓度。

公开(公告)号：US20100159483A1

公开(公告)日：2010-06-24

申请号：US12579484

申请日：2009-10-15

Applicant: Ji Won KIM ,  Beom Seok LEE ,  In Wook KIM ,  Kui Hyun KIM

Inventor： Ji Won KIM ,  Beom Seok LEE ,  In Wook KIM ,  Kui Hyun KIM

IPC: G01N33/542 ,  C12N11/00 ,  C12Q1/28

CPC classification number: G01N33/54366

Abstract: Disclosed are an article for assaying a target, wherein the article includes a solid surface on which a first binding member, a blocking material, and a second binding member are immobilized, a method of manufacturing the article, and a method of detecting a target using the article.

Abstract translation: 公开了一种用于测定靶的制品，其中所述制品包括其上固定有第一结合构件，阻挡材料和第二结合构件的固体表面，制造所述制品的方法，以及使用 文章。

公开(公告)号：US20100060697A1

公开(公告)日：2010-03-11

申请号：US12620856

申请日：2009-11-18

Applicant: Beom-seok LEE ,  Jeong-gun LEE ,  In-seok KANG ,  Jin-seok HONG ,  Dustin MOON

Inventor： Beom-seok LEE ,  Jeong-gun LEE ,  In-seok KANG ,  Jin-seok HONG ,  Dustin MOON

IPC: B41J2/14

CPC classification number: B41J2/06 ,  B41J2/14

Abstract: A method of printing droplets using capillary electric charge concentration includes: providing a capillary nozzle comprising a back-end part and a front-end part disposed substantially opposite the back-end part; spacing a target member apart from the front-end part of the capillary nozzle at a predetermined distance; immersing the back-end part in a solution; and supplying a voltage to the solution. The back-end part transmits the solution to the front-end part.

Abstract translation: 使用毛细管电荷浓度印刷液滴的方法包括：提供包括后端部分和基本上与后端部分相对设置的前端部分的毛细管喷嘴; 将目标构件与毛细管喷嘴的前端部隔开预定距离; 将后端部分浸入溶液中; 并向该溶液提供电压。 后端部分将解决方案传输到前端部分。

公开(公告)号：US20100050751A1

公开(公告)日：2010-03-04

申请号：US12546302

申请日：2009-08-24

Applicant: Beom-seok LEE

Inventor： Beom-seok LEE

IPC: G01N1/00

CPC classification number: G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00495 ,  Y10T137/206 ,  Y10T137/2224

Abstract: Provided is a microfluidic device. The microfluidic device includes a sample chamber in which a sample is accommodated. The sample chamber includes: an introduction portion including a loading hole through which the sample is loaded; an accommodation portion including a discharge hole; and a neck portion forming a boundary between the introduction portion and the accommodation portion. The neck portion provides a capillary pressure for controlling flow of the sample between the introduction portion and the accommodation portion.

Abstract translation: 提供了一种微流体装置。 微流体装置包括容纳样品的样品室。 样品室包括：引入部分，其包括加载样品的加载孔; 一个容纳部分，包括排放孔; 以及形成导入部和容纳部之间的边界的颈部。 颈部提供用于控制在引入部分和容纳部分之间的样品流动的毛细管压力。

公开(公告)号：US07600840B2

公开(公告)日：2009-10-13

申请号：US11503786

申请日：2006-08-14

Applicant: Su-hyeon Kim ,  Jeong-gun Lee ,  Jong-suk Chung ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

Inventor： Su-hyeon Kim ,  Jeong-gun Lee ,  Jong-suk Chung ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

IPC: B41J29/38

CPC classification number: B41J2/06 ,  B01J19/0046 ,  B01J2219/00364 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00743 ,  B41J2/04535 ,  B41J2/0456 ,  B41J2/04576

Abstract: A device for printing a droplet onto a substrate includes: a droplet generating member which is needle-shaped and comprises a receiving portion disposed vertically to receive a solution, and a discharge hole connected to the receiving portion and formed on a bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate disposed below the droplet generating member, the substrate includes a target portion to which the droplet discharged from the discharge hole of the droplet generating member is dropped and attached; a voltage applier applying a voltage to the droplet so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet.

Abstract translation: 用于将液滴印刷到基板上的装置包括：液滴产生构件，其为针状并且包括垂直设置以接收溶液的接收部分，以及连接到接收部分并形成在接收部分的底部上的排出孔 使得溶液可以从接收部分排出; 设置在所述液滴产生部件下方的基板，所述基板包括从所述液滴产生部件的排出孔排出的液滴滴落并附着到的目标部分; 电压施加器，向所述液滴施加电压，使得所述液滴能够落到所述基板的所述目标部分上; 体积测量单元，测量液滴的体积; 以及液滴控制单元，其基于所测量的液滴体积将液滴的体积保持在预定水平。

公开(公告)号：US20080252905A1

公开(公告)日：2008-10-16

申请号：US11875973

申请日：2007-10-22

Applicant: Jeong-gun LEE ,  Beom-seok LEE ,  Jong-myeon PARK ,  Jung-suk Yoo

Inventor： Jeong-gun LEE ,  Beom-seok LEE ,  Jong-myeon PARK ,  Jung-suk Yoo

IPC: G01B11/14

CPC classification number: G01N35/00069 ,  B01L3/5027 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2400/0409 ,  G01N35/0092 ,  G01N2035/00574

Abstract: Provided is a centrifugal force based microfluidic system including: a microfluidic device including a rotatable platform and an optical path formed to extend horizontally in a straight line from a circumference of the platform; a motor rotating so as to control the microfluidic device; a light emitting unit emitting light towards the microfluidic device; a light receiving unit detecting the light emitted from the light emitting unit; and a controller determining a home position to be the position of the microfluidic device at a point of time when the light emitted from the light emitting unit is detected by the light receiving unit, wherein the light emitted from the light emitting unit passes through the optical path to be incident on the light receiving unit only when the microfluidic device is located in a predetermined position.

Abstract translation: 提供了一种基于离心力的微流体系统，包括：微流体装置，其包括可旋转平台和形成为从平台的圆周以直线水平延伸的光路; 旋转的马达以控制微流体装置; 向所述微流体装置发射光的发光单元; 光接收单元，检测从所述发光单元发射的光; 以及控制器，其在从所述光接收单元检测到从所述发光单元发射的光的时刻，将所述微流体装置的位置确定为所述位置，其中，从所述发光单元发射的光通过所述光 仅当微流体装置位于预定位置时入射在光接收单元上的路径。

公开(公告)号：US20080225087A1

公开(公告)日：2008-09-18

申请号：US11970301

申请日：2008-01-07

Applicant: Beom-seok LEE ,  Jeong-gun LEE ,  Hye-jung CHO ,  In-seok KANG ,  Jae-suk MOON ,  Jin-seok HONG

Inventor： Beom-seok LEE ,  Jeong-gun LEE ,  Hye-jung CHO ,  In-seok KANG ,  Jae-suk MOON ,  Jin-seok HONG

IPC: B41J2/06

CPC classification number: B01L3/0262 ,  B01J19/0046 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00689 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01J2219/00743 ,  B01L2300/0819 ,  B01L2300/0838 ,  B01L2400/027 ,  Y10T436/11 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/25 ,  Y10T436/2575

Abstract: Disclosed is an apparatus and method for ejecting droplets using charge concentration and liquid bridge breakup. The droplet ejection apparatus includes a reservoir storing a liquid; a capillary nozzle having a lower end submerged in the liquid stored in the reservoir and an upper end exposed outside the surface of the liquid, the capillary nozzle transferring the liquid to the upper end using capillary force; a potentiostat for applying a voltage to the liquid; a substrate mount on which a substrate is disposed to face the upper end of the capillary nozzle; and a distance adjusting unit for reciprocatingly moving the substrate between first and second positions with respect to the capillary nozzle, wherein the first position denotes a position where a distance between the upper end of the capillary nozzle and the surface of the substrate is less than a effective distance.

Abstract translation: 公开了一种使用电荷浓度和液桥分解喷射液滴的装置和方法。 液滴喷射装置包括储存液体的储存器; 毛细喷嘴，其下端浸没在存储在储存器中的液体中，上端暴露在液体表面之外，毛细喷嘴使用毛细管力将液体传送到上端; 用于向液体施加电压的恒电位仪; 基板安装件，基板设置在其上面对毛细管喷嘴的上端; 以及距离调节单元，用于使所述基板相对于所述毛细管喷嘴在第一位置和所述第二位置之间往复移动，其中所述第一位置表示所述毛细管喷嘴的上端与所述基板的表面之间的距离小于 有效距离。

公开(公告)号：US20080112855A1

公开(公告)日：2008-05-15

申请号：US11937135

申请日：2007-11-08

Applicant: Beom-seok Lee ,  Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park

Inventor： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park

IPC: B01J19/00 ,  F16K13/10

CPC classification number: B01L3/502738 ,  B01L2300/0806 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677 ,  Y10T137/4643 ,  Y10T436/2575

Abstract: Provided are a valve unit and a microfluidic device including the valve unit. The valve unit includes: a valve substance container containing a valve substance, the valve substance including a phase change material that is solid at ambient temperature and melts by absorbing energy; a valve connection path connecting the valve substance container to a channel forming a fluid passage; and a pair of drain chambers formed along the channel at both sides of the valve connection path.

Abstract translation: 提供了包括阀单元的阀单元和微流体装置。 所述阀单元包括：阀体物质容器，其容纳阀门物质，所述阀门物质包括在环境温度下为固体并通过吸收能量而熔化的相变材料; 将阀体容器连接到形成流体通道的通道的阀连接路径; 以及在阀连接路径的两侧沿着通道形成的一对排水室。

公开(公告)号：US20070035587A1

公开(公告)日：2007-02-15

申请号：US11503721

申请日：2006-08-14

Applicant: Jeong-gun Lee ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

Inventor： Jeong-gun Lee ,  Hye-jung Cho ,  Nam Huh ,  In-seok Kang ,  Beom-seok Lee

IPC: B41J2/06

CPC classification number: B01L3/0262 ,  B01J19/0046 ,  B01J2219/00364 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00574 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00743 ,  B01L2300/0838 ,  B01L2400/027

Abstract: A device and method for printing biomolecules on a substrate uses an electric charge concentration effect. The device overcomes limitations of the material and surface characteristics of a substrate, enables accurate dropping of a biomolecular droplet onto a target surface of the substrate, prevents electric discharge, and thus allows the manufacturing of a high density biochip by depositing numerous biomolecular droplets, which are small in size and volume, onto a substrate. The device includes: a needle-shaped electric field forming electrode; a substrate which is grounded and disposed below the electric field forming electrode, the substrate including a target surface; and an open circuit type voltage applying unit which supplies first electric charges to the electric field forming electrode to drop the biomolecular droplet onto the target surface of the substrate.

Abstract translation: 用于在基板上印刷生物分子的装置和方法使用电荷浓度效应。 该器件克服了衬底的材料和表面特性的局限性，能够将生物分子液滴精确地滴落到衬底的靶表面上，防止放电，从而允许通过沉积许多生物分子液滴来制造高密度生物芯片， 尺寸和体积小到衬底上。 该装置包括：针状电场形成电极; 基板，其接地并设置在所述电场形成电极下方，所述基板包括目标表面; 以及开路型电压施加单元，其向所述电场形成电极提供第一电荷，以将所述生物分子液滴落到所述基板的所述目标表面上。