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41.发明授权公开(公告)号：US09081082B2
公开(公告)日：2015-07-14
申请号：US13299866
申请日：2011-11-18
Applicant: Xinyu Zhang , Bin Ye
Inventor： Xinyu Zhang , Bin Ye
CPC classification number: G01S5/14 , A61B6/4494 , A61B6/547 , A61B6/563 , G01S5/0252
Abstract: A system for wireless detector application in a medical system is provided. The system includes at least three host wire adapters configured to receive beacon messages broadcast periodically by a wireless detector, and obtain information about the wireless detector based on the received beacon messages. The system further includes a controller configured to receive information about the wireless detector from the at least three host wire adapters, and determine a position of the wireless detector based on the received information.
Abstract translation: 提供了一种用于医疗系统中的无线检测器应用的系统。 该系统包括被配置为接收由无线检测器周期性广播的信标消息的至少三个主机线适配器，并且基于接收到的信标消息获得关于无线检测器的信息。 该系统还包括控制器，其被配置为从至少三个主机线适配器接收关于无线检测器的信息，并且基于接收到的信息来确定无线检测器的位置。
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公开(公告)号：US08642347B2
公开(公告)日：2014-02-04
申请号：US12865508
申请日：2009-01-30
Applicant: Bin Ye , Daniel Cramer
Inventor： Bin Ye , Daniel Cramer
CPC classification number: G01N33/57449 , C07K14/4748
Abstract: The present invention is directed to diagnostic methods based upon the detection of peptides derived from the degradation of CA125. In particular, it is concerned with assays of urine samples collected from women for the purpose of determining whether they are at increased risk for having ovarian cancer, have decreased their risk as the result of clinical or non-clinical procedures, to monitor the efficacy of a treatment method, or to determine whether cancer has recurred or advanced.
Abstract translation: 本发明涉及基于检测衍生自CA125降解的肽的诊断方法。 特别地，它涉及从妇女收集的尿液样品的测定，以确定它们是否具有增加的患有卵巢癌的风险，降低其作为临床或非临床程序的结果的风险，以监测其功效 治疗方法，或确定癌症是否复发或进展。
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43.发明申请公开(公告)号：US20130127613A1
公开(公告)日：2013-05-23
申请号：US13299866
申请日：2011-11-18
Applicant: Xinyu Zhang , Bin Ye
Inventor： Xinyu Zhang , Bin Ye
IPC: G08B1/08
CPC classification number: G01S5/14 , A61B6/4494 , A61B6/547 , A61B6/563 , G01S5/0252
Abstract: A system for wireless detector application in a medical system is provided. The system includes at least three host wire adapters configured to receive beacon messages broadcast periodically by a wireless detector, and obtain information about the wireless detector based on the received beacon messages. The system further includes a controller configured to receive information about the wireless detector from the at least three host wire adapters, and determine a position of the wireless detector based on the received information.
Abstract translation: 提供了一种用于医疗系统中的无线检测器应用的系统。 该系统包括被配置为接收由无线检测器周期性广播的信标消息的至少三个主机线适配器，并且基于接收到的信标消息获得关于无线检测器的信息。 该系统还包括控制器，其被配置为从至少三个主机线适配器接收关于无线检测器的信息，并且基于接收到的信息来确定无线检测器的位置。
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公开(公告)号：US07828481B2
公开(公告)日：2010-11-09
申请号：US12238093
申请日：2008-09-25
IPC: A61B6/04
CPC classification number: A61B6/4283 , A61B6/0457 , A61B6/105 , G03B42/025
Abstract: A medical table wherein a top board on which a patient is placed is supported by a base having an internal instrument so as to be movable parallel to the board surface, the medical table includes a detecting device that detects the possibility that a hand or fingers, which grip the top board, come in contact with the internal instrument during the movement of the top board or internal instrument, and a preventing device that prevents the movement of the top board or the internal instrument on the basis of a detection signal of the detecting device.
Abstract translation: 一种医用台，其中放置有患者的顶板由具有内部器具的基座支撑以平行于所述板表面移动，所述医用台包括检测装置，其检测手或手指的可能性， 在顶板或内部仪器的运动过程中抓住顶板与内部仪器接触，防止装置根据检测的检测信号防止顶板或内部仪器的移动 设备。
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公开(公告)号：US07794145B2
公开(公告)日：2010-09-14
申请号：US12238176
申请日：2008-09-25
IPC: A61B6/04
Abstract: A medical table in which a top plate for a patient to lie on is supported by a pedestal base in a manner to be able to move parallel to a plate surface, includes a detecting device for detecting that fingers holding the top plate are about to collide against the pedestal base when moving the top plate, and a stopping device for stopping movement of the top plate according to a detection signal from the detecting device.
Abstract translation: 一种医疗台，其中用于患者躺着的顶板以能够平行于板表面的方式由基座支撑，包括检测装置，用于检测保持顶板的手指即将碰撞 在移动顶板时抵靠基座;以及停止装置，用于根据来自检测装置的检测信号停止顶板的移动。
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Patent Agency Ranking
公开(公告)号：US20070155726A1
公开(公告)日：2007-07-05
申请号：US11644244
申请日：2006-12-22
Applicant: Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye
Inventor： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye
IPC: A61K31/551 , A61K31/495 , A61K31/46 , A61K31/445 , A61K31/407
CPC classification number: C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04
Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
Abstract translation: 本发明涉及式（I）化合物：其中r，q，R，R 2，R 3，R 4，R R 5，R 5b，R 5c，R 6a，R 6b，R 6b，R 6b，R 6b，R 6b， 本文描述了作为单一立体异构体或作为其中R 1，R 2，R 8和R 9的混合物 立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药; 其是白三烯A 4水解酶抑制剂，因此可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。
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公开(公告)号：US06841673B2
公开(公告)日：2005-01-11
申请号：US10121886
申请日：2002-04-12
Applicant: Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
Inventor： Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
IPC: C07D403/14 , A61K31/506 , A61K31/5377 , A61K31/547 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D213/00 , C07D233/00 , C07D239/00 , C07D241/02 , C07D265/00 , C07D279/00 , C07D317/44 , C07D319/00 , C07D333/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D521/00 , C07D239/70
CPC classification number: C07D231/12 , C07D233/56 , C07D249/08
Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
Abstract translation: 式（I）的N-杂环衍生物：本文描述以及其它N-杂环作为一氧化氮合酶的抑制剂。 含有这些化合物的药物组合物，使用这些化合物作为一氧化氮合酶抑制剂的方法以及合成这些化合物的方法也在本文中描述。
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公开(公告)号：US06670473B2
公开(公告)日：2003-12-30
申请号：US10121808
申请日：2002-04-12
Applicant: Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
Inventor： Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
IPC: C07D47316
CPC classification number: C07D231/12 , C07D233/56 , C07D249/08
Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
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公开(公告)号：US06498185B1
公开(公告)日：2002-12-24
申请号：US09631452
申请日：2000-08-03
Applicant: Damian O. Arnaiz , Yuo-Ling Chou , Brian D. Griedel , Rushad E. Karanjawala , Monica J. Kochanny , Wheeseong Lee , Amy Mei Liang , Michael M. Morrissey , Gary B. Phillips , Karna Lyn Sacchi , Steven T. Sakata , Kenneth J. Shaw , R. Michael Snider , Shung C. Wu , Bin Ye , Zuchun Zhao
Inventor： Damian O. Arnaiz , Yuo-Ling Chou , Brian D. Griedel , Rushad E. Karanjawala , Monica J. Kochanny , Wheeseong Lee , Amy Mei Liang , Michael M. Morrissey , Gary B. Phillips , Karna Lyn Sacchi , Steven T. Sakata , Kenneth J. Shaw , R. Michael Snider , Shung C. Wu , Bin Ye , Zuchun Zhao
IPC: A01N4306
CPC classification number: C07D401/04 , C07D333/38 , C07D333/70 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/06 , C07D473/34
Abstract: This invention is directed to compounds of formula (III): wherein B, C, D, E, R1, R2 and R3 are disclosed herein. These compounds are disclosed as being useful as anti coagulants.
Abstract translation: 本发明涉及式（III）化合物：其中B，C，D，E，R 1，R 2和R 3在本文中公开。 公开了这些化合物作为抗凝剂。
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50.发明授权O-malonyltryrosyl compounds, O-malonyltryrosyl compound-containing peptides, and use thereof 失效O-丙二酰基酪酰基化合物，含有O-丙二酰基特异性基化合物的肽及其用途
公开(公告)号：US5688992A
公开(公告)日：1997-11-18
申请号：US414520
申请日：1995-03-31
Applicant: Terrence R. Burke, Jr. , Bin Ye , Miki Akamatsu , Hemanta K. Kole , Xinjian Yan , Peter R. Roller
Inventor： Terrence R. Burke, Jr. , Bin Ye , Miki Akamatsu , Hemanta K. Kole , Xinjian Yan , Peter R. Roller
IPC: A61K38/00 , A61K31/195 , A61K31/215 , A61P3/08 , A61P3/10 , A61P35/00 , A61P37/04 , A61P43/00 , C07C229/36 , C07C237/20 , C07C271/22 , C07K5/065 , C07K7/06 , C07K14/47 , C07K14/705 , C07C57/145 , A61K31/19
CPC classification number: C07C271/22 , C07C229/36 , C07C237/20 , C07K14/705 , C07K5/06078 , A61K38/00 , C07C2103/18
Abstract: The present invention relates to non-phosphorus containing O-malonyltryrosyl compounds, derivatives thereof, uses of the O-malonyltryrosyl compounds in the synthesis of peptides, and O-malonyltryrosyl compound-containing peptides. The O-malonyltyrosyl malonyltyrosyl compounds and O-malonyltryrosyl compound-containing peptides of the present invention are uniquely stable to phosphotases, capable of crossing cell membranes, suitable for application to peptide synthesis of O-malonyltryrosyl compound-containing peptides, and amenable to prodrag defivatization for delivery into cells. The present invention also provides for O-malonyltryrosyl compound-containing peptides which exhibit inhibitory potency against binding interactions of receptor domains with phosphotyrosyl-containing peptide ligands.
Abstract translation: 本发明涉及不含磷的O-壬二酰基特异性基团的化合物，其衍生物，O-丙二酰基二辛基化合物在肽的合成中的应用，以及含有O-丙二酰基二酰基化合物的肽。 本发明的O-丙二酰基特异酰基丙二酰基酪氨酸化合物和含O-丙二酰基酪酰基化合物的肽对于能够与细胞膜交叉的磷酸酶是独特稳定的，适用于肽合成含有O-丙二酰基二酰基化合物的肽，并且适于产生衍生化 用于送入细胞。 本发明还提供了对具有含磷酰基的肽配体的受体结构域的结合相互作用具有抑制效力的含有O-丙二酰基二酰基化合物的肽。
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