公开(公告)号：US09850495B2

公开(公告)日：2017-12-26

申请号：US14384695

申请日：2013-03-14

Applicant: E I DU PONT DE NEMOURS AND COMPANY ,  COLD SPRING HARBOR LABORATORY ,  IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

Inventor： Stephen M Allen ,  David Peter Jackson ,  Mai Komatsu ,  Michael Pautler ,  Hajime Sakai ,  Erik Vollbrecht ,  Rebecca Weeks

IPC: C12N15/87 ,  C12N15/82 ,  A01H5/10 ,  C07K14/415 ,  C12Q1/68

CPC classification number: C12N15/8261 ,  A01H5/10 ,  C07K14/415 ,  C12N15/8216 ,  C12N15/8229 ,  C12Q1/6895 ,  C12Q2600/13 ,  C12Q2600/156 ,  Y02A40/146

Abstract: Methods and compositions for modulating shoot apical meristem size are provided. Methods are provided for modulating the expression of Fea4 sequence in a host plant or plant cell to modulate agronomic characteristics such as altered size and number of organs, including plant seeds.

公开(公告)号：US09815849B2

公开(公告)日：2017-11-14

申请号：US13934843

申请日：2013-07-03

Applicant: Dana-Farber Cancer Institute, Inc. ,  Cold Spring Harbor Laboratory

Inventor： James Elliott Bradner ,  Johannes Zuber ,  Junwei Shi ,  Christopher R. Vakoc ,  Scott W. Lowe ,  Constantine S. Mitsiades

IPC: A61K31/55 ,  C07D495/14 ,  C12N15/11 ,  C12N15/113 ,  A61K31/5517 ,  C12Q1/68

CPC classification number: C07D495/14 ,  A61K31/5517 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2330/51 ,  C12Q1/6886

Abstract: The invention provides compositions, methods, and kits for the treatment of acute myeloid leukemia in a subject.

公开(公告)号：US20170296561A1

公开(公告)日：2017-10-19

申请号：US15514415

申请日：2015-09-23

Applicant: Cold Spring Harbor Laboratory

Inventor： Nicholas Tonks ,  Navasona Krishnan

IPC: A61K31/662 ,  C12Q1/68

CPC classification number: A61K31/662 ,  C07F9/3808 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The present invention relates to agents and methods for treating autism spectrum disorders, such as Rett Syndrome. This invention addresses the need mentioned above by providing agents and methods for treating or ameliorating symptoms of neurologic diseases, such as autism spectrum disorders and Rett Syndrome. In one aspect, the invention provides a method for treating a neurologic disease associated with one or more mutations in the MECP2 gene.

公开(公告)号：US20170275642A1

公开(公告)日：2017-09-28

申请号：US15612106

申请日：2017-06-02

Applicant: E I Du Pont de Nemours and Company ,  Cold Spring Harbor Laboratory

Inventor： Stephen M. Allen ,  David Peter Jackson ,  Byoung IL Je ,  Mai Komatsu ,  Young Koung Lee ,  Hajime Sakai

IPC: C12N15/82 ,  A01H5/10

CPC classification number: C12N15/8261 ,  A01H5/10 ,  C12N15/8229 ,  C12N15/8241

Abstract: Methods and compositions for modulating shoot apical meristem size are provided. Methods are provided for modulating the expression of fea3 sequence in a host plant or plant cell to modulate agronomic characteristics such as altered size and number of organs, including plant seeds.

公开(公告)号：US09717750B2

公开(公告)日：2017-08-01

申请号：US14617388

申请日：2015-02-09

Applicant: Biogen MA Inc. ,  Cold Spring Harbor Laboratory

Inventor： C. Frank Bennett ,  Gene Hung ,  Frank Rigo ,  Adrian R. Krainer ,  Yimin Hua ,  Marco A. Passini ,  Lamya Shihabuddin ,  Seng H. Cheng ,  Katherine W. Klinger

IPC: C07H21/02 ,  C07H21/04 ,  A61K31/70 ,  A61K31/7088 ,  C12N15/113 ,  C12Q1/68 ,  A61K31/712

CPC classification number: A61K31/7088 ,  A61K31/712 ,  C12N15/113 ,  C12N2310/11 ,  C12N2320/33

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.

公开(公告)号：US20170121770A1

公开(公告)日：2017-05-04

申请号：US15258078

申请日：2016-09-07

Applicant: Cold Spring Harbor Laboratory

Inventor： Joshua Dubnau ,  Wanhe Li ,  Lisa Prazak ,  Molly Hammell ,  Ying Jin

IPC: C12Q1/68 ,  C12N15/113

CPC classification number: C12Q1/6883 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/141 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: A method that includes measuring the expression level of at least one transposon in a biological sample from a subject; and determining whether the measured transposon expression exceeds a predetermined level, and if so, administering to the subject a transposon inhibitor in an amount effective to reduce the expression level of a transposon.

公开(公告)号：US09624494B2

公开(公告)日：2017-04-18

申请号：US14630419

申请日：2015-02-24

Applicant: Cold Spring Harbor Laboratory

Inventor： Gregory J. Hannon ,  Sihem Cheloufi

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/85 ,  C12N15/113 ,  C12N15/11

CPC classification number: C12N15/113 ,  A01K2207/05 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/30

Abstract: Provided is an improved design of shRNA based on structural mimics of miR-451 precursors. These miR-451 shRNA mimics are channeled through a novel small RNA biogenesis pathway, require AGO2 catalysis and are processed by Drosha but are independent of DICER processing. This miRNA pathway feeds active elements only into Ago2 because of its unique catalytic activity. These data demonstrate that this newly identified small RNA biogenesis pathway can be exploited in vivo to produce active molecules.

公开(公告)号：US20170051282A1

公开(公告)日：2017-02-23

申请号：US15217455

申请日：2016-07-22

Applicant: Cold Spring Harbor Laboratory

Inventor： Thomas R. GINGERAS ,  Sudipto K. CHAKRABORTTY ,  Ashwin PRAKASH ,  Gal NECHOOSHTAN

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/113 ,  C12N2310/11 ,  C12N2320/30 ,  C12N2330/50 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/178 ,  G01N33/5017

Abstract: Disclosed herein are methods and compositions for treating cancers.

Abstract translation: 本文公开了用于治疗癌症的方法和组合物。

公开(公告)号：US09422605B2

公开(公告)日：2016-08-23

申请号：US14216491

申请日：2014-03-17

Applicant: Cold Spring Harbor Laboratory

Inventor： Joshua Dubnau ,  Wanhe Li ,  Lisa Prazak

IPC: C07H21/02 ,  C07H21/04 ,  C12Q1/68

CPC classification number: C12N15/113 ,  C12N2310/14 ,  C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: The present invention relates to transposon activation and mobilization, particularly in the brain, during normal aging; reporter systems to detect such mobilization, along with cells and transgenic animals containing such systems; methods of monitoring neuronal function during normal aging; methods of determining the risk of age-related neuronal decline and age-related mortality; and the use of transposon inhibitors and apoptosis inhibitors to delay age-related neuronal decline and age-related mortality.

Abstract translation: 本发明涉及在正常老化期间转座子活化和动员，特别是在脑中的活化; 用于检测这种动员的记录系统，以及含有这种系统的细胞和转基因动物; 监测正常老化过程中神经元功能的方法; 确定年龄相关神经元衰退和年龄相关死亡风险的方法; 并使用转座子抑制剂和凋亡抑制剂来延缓年龄相关的神经元衰退和与年龄有关的死亡率。

公开(公告)号：US20160017347A1

公开(公告)日：2016-01-21

申请号：US14409990

申请日：2013-06-17

Applicant: E. I. DU PONT DE NEMOURS AND COMPANY ,  COLD SPRING HARBOR LABORATORY

Inventor： Stephen M. Allen ,  Zachary B. Lippman ,  Cora A. Macalister

IPC: C12N15/82 ,  C07K14/415

CPC classification number: C12N15/827 ,  C07K14/415 ,  C12N15/8218 ,  C12N15/8261

Abstract: Described herein are the following: isolated polynucleotides, isolated polypeptides and recombinant DNA constructs; compositions (such as plants or seeds) comprising these recombinant DNA constructs; and methods of use for these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a TMF polypeptide.

Abstract translation: 本文描述如下：分离的多核苷酸，分离的多肽和重组DNA构建体; 包含这些重组DNA构建体的组合物（例如植物或种子） 和这些重组DNA构建体的使用方法。 重组DNA构建体包含可操作地连接于在植物中有功能的启动子的多核苷酸，其中所述多核苷酸编码TMF多肽。