公开(公告)号：US20190247408A1

公开(公告)日：2019-08-15

申请号：US16377875

申请日：2019-04-08

Applicant: Cold Spring Harbor Laboratory

Inventor： Nicholas Tonks ,  Navasona Krishnan

IPC: A61K31/662 ,  C12Q1/6883 ,  C07F9/38

CPC classification number: A61K31/662 ,  C07F9/3808 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The present invention relates to agents and methods for treating autism spectrum disorders, such as Rett Syndrome.

公开(公告)号：US20170296561A1

公开(公告)日：2017-10-19

申请号：US15514415

申请日：2015-09-23

Applicant: Cold Spring Harbor Laboratory

Inventor： Nicholas Tonks ,  Navasona Krishnan

IPC: A61K31/662 ,  C12Q1/68

CPC classification number: A61K31/662 ,  C07F9/3808 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The present invention relates to agents and methods for treating autism spectrum disorders, such as Rett Syndrome. This invention addresses the need mentioned above by providing agents and methods for treating or ameliorating symptoms of neurologic diseases, such as autism spectrum disorders and Rett Syndrome. In one aspect, the invention provides a method for treating a neurologic disease associated with one or more mutations in the MECP2 gene.

公开(公告)号：US12178825B2

公开(公告)日：2024-12-31

申请号：US17866724

申请日：2022-07-18

Applicant: COLD SPRING HARBOR LABORATORY ,  DEPYMED, INC.

Inventor： Nicholas Tonks ,  Navasona Krishnan ,  Andreas Grill ,  Howard Sard

IPC: A61K31/58 ,  A61K31/4184

Abstract: Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I.

公开(公告)号：US12215128B2

公开(公告)日：2025-02-04

申请号：US17261313

申请日：2019-07-19

Applicant: COLD SPRING HARBOR LABORATORY ,  DEPYMED, INC.

Inventor： Nicholas Tonks ,  Navasona Krishnan ,  Andreas Grill

IPC: C07D213/38 ,  C07D401/12 ,  C07J43/00

Abstract: Compounds of formula: are described herein. The compounds selectively complex copper and are therefore useful both abiotically for measuring and detecting small amounts of copper and, in biological systems, for treating diseases associated with inappropriate copper levels, such as Wilson's disease and gastric cancer.

公开(公告)号：US11660306B2

公开(公告)日：2023-05-30

申请号：US16377875

申请日：2019-04-08

Applicant: Cold Spring Harbor Laboratory

Inventor： Nicholas Tonks ,  Navasona Krishnan

IPC: A61K31/662 ,  C07F9/38 ,  C12Q1/6883

CPC classification number: A61K31/662 ,  C07F9/3808 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The present invention relates to agents and methods for treating autism spectrum disorders, such as Rett Syndrome.

公开(公告)号：US11406647B2

公开(公告)日：2022-08-09

申请号：US16761631

申请日：2018-11-06

Applicant: COLD SPRING HARBOR LABORATORY ,  DEPYMED, INC.

Inventor： Nicholas Tonks ,  Navasona Krishnan ,  Andreas Grill ,  Howard Sard

IPC: A61K31/58 ,  A61K31/4184

Abstract: Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I.