公开(公告)号：US20220106276A1

公开(公告)日：2022-04-07

申请号：US17311873

申请日：2019-12-09

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Leah CLEARY ,  Melissa FLEURY ,  Zhonghua PEI ,  Richard STEEL ,  James SUTTON ,  John E. KNOX ,  Zachary E. R. NEWBY

IPC: C07D239/95 ,  C07D401/04 ,  C07D405/12 ,  C07D417/04 ,  C07D403/04 ,  C07D413/04 ,  A61P35/00 ,  C07D239/96 ,  C07D471/04

Abstract: Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

公开(公告)号：US20210254006A1

公开(公告)日：2021-08-19

申请号：US16972181

申请日：2019-06-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Fred ASWAD ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  Yujiro HATA ,  James Clifford SUTTON, Jr.

IPC: C12N5/0789 ,  A61K35/28 ,  A61L29/16 ,  A61L31/16

Abstract: Provided are methods for expanding stem cells and/or lineage committed progenitor cells, at least in part, by using lactam compounds that antagonize AhR. The compounds are represented by formula (I): wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided below. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.