公开(公告)号：US20240208965A1

公开(公告)日：2024-06-27

申请号：US18009172

申请日：2021-06-09

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Leah CLEARY ,  Melissa FLEURY ,  Zhonghua PEI ,  John E. KNOX

IPC: C07D471/04 ,  A61K31/517 ,  A61K31/519 ,  C07D403/06 ,  C07D403/14 ,  C07D417/06

CPC classification number: C07D471/04 ,  A61K31/517 ,  A61K31/519 ,  C07D403/06 ,  C07D403/14 ,  C07D417/06

Abstract: Disclosed herein are certain heteroaryl alkylene substituted 2-oxoquinazoline derivatives of Formula (I): (I) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

公开(公告)号：US20230227409A1

公开(公告)日：2023-07-20

申请号：US18009206

申请日：2021-06-09

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Leah CLEARY ,  Melissa FLEURY ,  Zhonghua PEI

IPC: C07D215/22 ,  C07D215/227 ,  C07D215/36 ,  C07D495/04 ,  C07D215/38 ,  C07D401/04 ,  C07D417/12

CPC classification number: C07D215/22 ,  C07D215/227 ,  C07D215/36 ,  C07D495/04 ,  C07D215/38 ,  C07D401/04 ,  C07D417/12

Abstract: Disclosed herein are certain quinolinone derivatives of Formula (A) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

公开(公告)号：US20230078112A1

公开(公告)日：2023-03-16

申请号：US17615123

申请日：2020-05-29

Applicant: IDEAYA Biosciences, Inc.

Inventor： Paul A. BARSANTI ,  Hilary Plake BECK ,  Melissa FLEURY ,  John E. KNOX ,  Ethan DeNardo MCSPADDEN ,  Brian Thomas JONES ,  Luisruben P. MARTINEZ ,  Zhonghua PEI ,  Chenbo WANG

IPC: C07D417/14 ,  C07D498/18 ,  C07D417/12

Abstract: Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

公开(公告)号：US20220098154A1

公开(公告)日：2022-03-31

申请号：US17426408

申请日：2020-01-29

Applicant: IDEAYA Biosciences, Inc.

Inventor： Hilary Plake BECK ,  Michael DILLON ,  Brian JONES ,  Luisruben P. MARTINEZ ,  Zhonghua PEI

IPC: C07D213/85 ,  C07D213/64 ,  C07D213/74 ,  C07C237/04 ,  C07D215/54 ,  C07D221/18 ,  C07D217/26 ,  C07C255/58 ,  C07D239/42 ,  C07D405/12 ,  C07D401/12 ,  C07D409/12

Abstract: Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

公开(公告)号：US20230257359A1

公开(公告)日：2023-08-17

申请号：US18009194

申请日：2021-06-09

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Leah CLEARY ,  Melissa FLEURY ,  Zhonghua PEI ,  Richard STEEL

IPC: C07D401/04 ,  A61P35/00

CPC classification number: C07D401/04 ,  A61P35/00

Abstract: Disclosed herein are certain 4-arylquinazoline derivatives of Formula (I) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

公开(公告)号：US20220106276A1

公开(公告)日：2022-04-07

申请号：US17311873

申请日：2019-12-09

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Leah CLEARY ,  Melissa FLEURY ,  Zhonghua PEI ,  Richard STEEL ,  James SUTTON ,  John E. KNOX ,  Zachary E. R. NEWBY

IPC: C07D239/95 ,  C07D401/04 ,  C07D405/12 ,  C07D417/04 ,  C07D403/04 ,  C07D413/04 ,  A61P35/00 ,  C07D239/96 ,  C07D471/04

Abstract: Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.