公开(公告)号：US20220106276A1

公开(公告)日：2022-04-07

申请号：US17311873

申请日：2019-12-09

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Leah CLEARY ,  Melissa FLEURY ,  Zhonghua PEI ,  Richard STEEL ,  James SUTTON ,  John E. KNOX ,  Zachary E. R. NEWBY

IPC: C07D239/95 ,  C07D401/04 ,  C07D405/12 ,  C07D417/04 ,  C07D403/04 ,  C07D413/04 ,  A61P35/00 ,  C07D239/96 ,  C07D471/04

Abstract: Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.