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    CANCER DETECTION AND CLASSIFICATION USING METHYLOME ANALYSIS
    42.
    发明申请
    CANCER DETECTION AND CLASSIFICATION USING METHYLOME ANALYSIS 有权

    公开(公告)号：US20220251665A1

    公开(公告)日：2022-08-11

    申请号：US17668314

    申请日：2022-02-09

    Applicant: UNIVERSITY HEALTH NETWORK ,  SINAI HEALTH SYSTEM

    Inventor： Daniel DINIZ DE CARVALHO ,  Scott Victor BRATMAN ,  Rajat SINGHANIA ,  Ankur RAVINARAYANA CHAKRAVARTHY ,  Shu Yi SHEN

    IPC: C12Q1/6886 ,  C12Q1/6827

    Abstract: There is described herein a method of detecting the presence of DNA from cancer cells in a subject comprising: providing a sample of cell-free DNA from a subject; subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated, then optionally denaturing the sample; capturing cell-free methylated DNA using a binder selective for methylated polynucleotides; sequencing the captured cell-free methylated DNA; comparing the sequences of the captured cell-free methylated DNA to control cell-free methylated DNAs sequences from healthy and cancerous individuals and from individuals with distinct cancer types and subtypes; identifying the presence of DNA from cancer cells if there is a statistically significant similarity between one or more sequences of the captured cell-free methylated DNA and cell-free methylated DNAs sequences from cancerous individuals.

    3-D HUMAN MODEL OF COMPLEX CARDIAC ARRHYTHMIAS
    43.
    发明申请
    3-D HUMAN MODEL OF COMPLEX CARDIAC ARRHYTHMIAS 有权

    公开(公告)号：US20220251517A1

    公开(公告)日：2022-08-11

    申请号：US17668321

    申请日：2022-02-09

    Applicant: University Health Network

    Inventor： Sara S. Nunes de Vasconcelos ,  Kenneth Williams

    IPC: C12N5/071 ,  C12N5/00 ,  C12N5/077 ,  G01N33/50

    Abstract: Various embodiments are described herein for creating a 3D human heart model for modelling arrythmias, wherein the method comprises seeding a structure with a mixture of human cardiomyocytes, cardiac fibroblasts and a fibrin mixture to form cardiac tissue; applying a plating media for settlement and compaction of the cardiac tissue; and adding an arrhythmogenic media to the cardiac tissue, where the arrhythmogenic media comprises methyl-beta cyclodextrin for disrupting calcium signaling.

    T CELL RECEPTORS AND METHODS OF USE THEREOF
    45.
    发明申请
    T CELL RECEPTORS AND METHODS OF USE THEREOF 有权

    公开(公告)号：US20220169696A1

    公开(公告)日：2022-06-02

    申请号：US17436934

    申请日：2020-03-03

    Applicant: University Health Network

    Inventor： Naoto HIRANO ,  Kenji MURATA ,  Kayoko SASO

    IPC: C07K14/725 ,  C12N9/22 ,  C12N5/0783 ,  C12N15/62 ,  C12N15/86 ,  A61K35/17 ,  C07K14/74

    Abstract: The present disclosure is directed recombinant T cell receptors capable of binding a gp100 epitope and nucleic acid molecules encoding the same. In some embodiments, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence or the polypeptide encoded by the second nucleotide sequence inhibits the expression of an endogenous TCR. Other aspects of the disclosure are directed to vectors comprising the nucleic acid molecule and cells comprising the recombinant TCR, the nucleic acid molecule, or the vector. Still other aspects of the disclosure are directed to methods of using the same. In some embodiments, the methods comprise treating a cancer in a subject in need thereof.

    T CELL RECEPTORS AND METHODS OF USE THEREOF
    46.
    发明申请
    T CELL RECEPTORS AND METHODS OF USE THEREOF 有权

    公开(公告)号：US20220168346A1

    公开(公告)日：2022-06-02

    申请号：US17436939

    申请日：2020-03-03

    Applicant: University Health Network

    Inventor： Naoto HIRANO ,  Kenji MURATA ,  Kayoko SASO

    IPC: A61K35/17 ,  A61P35/00 ,  A61P37/04 ,  C07K14/725 ,  C07K14/74 ,  C12N15/62 ,  C12N15/86 ,  C12N5/0783

    Abstract: The present disclosure is directed recombinant T cell receptors capable of binding a gp100 epitope and nucleic acid molecules encoding the same. In some embodiments, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence or the polypeptide encoded by the second nucleotide sequence inhibits the expression of an endogenous TCR. Other aspects of the disclosure are directed to vectors comprising the nucleic acid molecule and cells comprising the recombinant TCR, the nucleic acid molecule, or the vector. Still other aspects of the disclosure are directed to methods of using the same. In some embodiments, the methods comprise treating a cancer in a subject in need thereof.

    CIRCULATING MICRORNAS IN KNEE OSTEOARTHRITIS AND USES THEREOF
    50.
    发明申请
    CIRCULATING MICRORNAS IN KNEE OSTEOARTHRITIS AND USES THEREOF 有权

    公开(公告)号：US20210381047A1

    公开(公告)日：2021-12-09

    申请号：US17337163

    申请日：2021-06-02

    Applicant: University Health Network

    Inventor： Mohit Kapoor ,  Rajiv Gandhi ,  Shabana Amanda Ali

    IPC: C12Q1/6876

    Abstract: A method staging of knee osteoarthritis (OA) comprising a) obtaining a substantially cell-free sample of blood plasma or blood serum from a subject with osteoarthritis; b) detecting a presence of or measuring a level of one or more miRNAs selected from hsa-miR-335-3p, hsa-miR-199a-5p, hsa-miR-671-3p, hsa-miR-1260b, hsa-miR-191-3p, hsa-miR-335-5p, hsa-miR-543, novel_miRNA_1 (gucuggcucaggguuggg) (SEQ ID NO: 1), novel_miRNA_2 (ucccuguucgggcgccacu) (SEQ ID NO: 2), novel_miRNA_3 (uguuuagcauccuguagccugc) (SEQ ID NO: 3), and novel_miRNA_4 (uaguggguuaucagaacu) (SEQ ID NO: 4); and c) identifying the subject as likely to have early stage osteoarthritis or late stage osteoarthritis based on the presence of or measured level of the one or more miRNAs. Isolated nucleic acids, primers, probes, panels and kits are also provided.

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