公开(公告)号：US20230390294A1

公开(公告)日：2023-12-07

申请号：US18235679

申请日：2023-08-18

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Mark Robert Bray ,  Jacqueline M. Mason ,  Tak Wah Mak ,  Graham Fletcher

IPC: A61K31/519 ,  A61P35/00 ,  A61K39/395

CPC classification number: A61K31/519 ,  A61P35/00 ,  A61K39/3955

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：US11766437B2

公开(公告)日：2023-09-26

申请号：US16635320

申请日：2018-08-01

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Mark Robert Bray ,  Jacqueline M. Mason ,  Tak W. Mak ,  Graham Fletcher

IPC: A61K31/519 ,  A61P35/00 ,  A61K39/395

CPC classification number: A61K31/519 ,  A61K39/3955 ,  A61P35/00

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：US20220204494A1

公开(公告)日：2022-06-30

申请号：US17605108

申请日：2020-04-23

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Sze-Wan Li ,  Mark Robert Bray

IPC: C07D413/14

Abstract: Disclosed is Crystal Form S4 of a fumarate salt of compound (I) represented by the following structural formula: (I) The molar ratio between compound (I) and fumaric acid is 1.0:1:0. Crystal Form S4, 5 characterized by an X-ray powder diffraction pattern which comprises peaks at 6.6°, 9.8°, 16.3°, 21.1°, 28.7°, and 30.2°±0.2 in 2θ.

公开(公告)号：US20200230144A1

公开(公告)日：2020-07-23

申请号：US16635320

申请日：2018-08-01

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Mark Robert Bray ,  Jacqueline M. Mason ,  Tak W. Mak ,  Graham Fletcher

IPC: A61K31/519 ,  A61K39/395 ,  A61P35/00

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.