公开(公告)号：US10722557B2

公开(公告)日：2020-07-28

申请号：US16315684

申请日：2017-07-14

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Antonio Abbate ,  Stefano Toldo

IPC: A61P9/10 ,  A61K38/55 ,  A61K38/17 ,  A61P7/02 ,  C07K14/81 ,  C07K14/705

Abstract: Methods of preventing and/or treating reperfusion injury are provided. The methods involve administering alpha-2-macroglobulin (A2MG) to a subject with ischemia in one or more tissues or organs, in order to prevent or decrease reperfusion injury when blood flow is restored to the tissues or organs (reperfusion). In some aspects, the patient who is treated has had a heart attack (e.g. acute myocardial infarction, AMI) and the ischemic tissue that is protected from reperfusion injury is heart tissue.

公开(公告)号：US20200146547A1

公开(公告)日：2020-05-14

申请号：US16745409

申请日：2020-01-17

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Paul A. WETZEL ,  Mark S. BARON ,  George T. GITCHEL

IPC: A61B3/113 ,  A61B5/11 ,  A61B5/00

Abstract: Objects of interest which project beyond the fovea are poorly resolved and lack color information, requiring movement of the eyes in order to obtain a comprehensive image and perception of the surrounding world. Eye movements emanate from different areas of the brain which can be affected by disease and or injury. As such, different neurological disorders will affect a myriad of eye movements in a variety of different ways. An automated system and method, capable of detecting, analyzing and summarizing a person's eye movements is used to detect (diagnose) (either before or after symptoms of said neurological disease are apparent), confirm a prior diagnosis, and/or to monitor the treatment effectiveness for a variety of neurological diseases, neurological movement disorders and potential brain injuries. The analyzed and summarized eye movements are cataloged, interpreted and utilized in a diagnostic matrix in order to highlight and distinguish abnormal eye movements, and to provide an objective clinical or pre-clinical/pre-symptomatic diagnosis based on the non-invasive testing procedures.

公开(公告)号：US20190352710A1

公开(公告)日：2019-11-21

申请号：US16475704

申请日：2018-01-05

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  NEW YORK UNIVERSITY ,  UNIVERSITY OF BRISTOL

Inventor： Jason REED ,  Bhubaneswar MISHRA ,  Andrey MIKHEYKIN ,  Loren PICCO ,  Oliver PAYTON ,  Freddie RUSSELL-PAVIER

IPC: C12Q1/6869 ,  G01Q20/02 ,  G01Q60/42 ,  C12N15/11 ,  C12N9/22

Abstract: Exemplary embodiments of the present disclosure can include, for example, an atomic force microscopy (AFM) system, including a cantilever(s), an optical pickup unit(s) (OPU(s)) including a laser positioned over the cantilever(s), and a power source providing noise with a noise level that is below 300 Picometers. The noise level of the power source can be below 200 Picometers. A digitizing arrangement can be included which can be associated with the OPU. The digitizing arrangement(s) can have a bandwidth of about 2 MHZ. The OPU(s) can have a detection bandwidth of at least 80 MHZ. The exemplary apparatus can be combined with a chemical protocol and statistical signal processing and image analysis procedures to map DNA at high speed and accuracy.

公开(公告)号：US10456370B2

公开(公告)日：2019-10-29

申请号：US16199337

申请日：2018-11-26

Applicant: Enzo Therapeutics, Inc. ,  Virginia Commonwealth University

Inventor： Sarah Spiegel ,  Robert Elliot Zipkin ,  Jeffrey Kroll Adams

IPC: A61K31/137 ,  A61P11/06 ,  A61K31/135 ,  A61K31/40 ,  C07C323/32 ,  C07D263/06 ,  C07D295/092 ,  C07C215/28 ,  C07C217/64 ,  C07C233/18

Abstract: Provided are inhibitors of sphingosine kinase Type I and their use in the treatment of asthma, among other indications and diseases.

公开(公告)号：US10451606B2

公开(公告)日：2019-10-22

申请号：US15030958

申请日：2014-10-21

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Rodney C. Daniels ,  Kevin R. Ward ,  Maryanne M. Collinson

IPC: G01N27/30 ,  G01N33/49 ,  G01N27/327 ,  B01L3/00 ,  G01N33/487

Abstract: A bioelectrochemical sensor utilizing a nanoporous gold electrode. The bioelectrochemical sensor is suitable for measuring redox in biologic media while having increased resistance to biofouling as compared to conventional electrodes such as planar gold electrodes, due to greater exposed surface area of the three-dimentional ligature structure defining the nanopores. The nanopores have a pore size of 5-100 nm, preferably with an average pore size of less than 50 nm, and more preferably with an average pore size of less than 20 nm.

公开(公告)号：US20190315999A1

公开(公告)日：2019-10-17

申请号：US16188192

申请日：2018-11-12

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Kenneth J. WYNNE ,  Wei ZHANG

IPC: C09D171/02 ,  C09K3/18 ,  C08G77/388 ,  C08G77/54 ,  C09D183/14 ,  C08L75/04 ,  C08L71/02 ,  C08G65/336 ,  C08K5/5465

Abstract: A compound is provided, having the formula (I), wherein RS is a soft block polymer; wherein each T is independently a urethane or urea linkage; see formulae (A) and (B); wherein each RD is independently —CH3, —CH2CH3, —CH2CH2CH3, or —CH2CH2CH2CH3; wherein each R′D is independently —CH3, —CH2CH3, —CH2CH2CH3, —CH2CH2CH2CH3, or —ORD; and wherein each p is independently 1, 2, or 3. Compositions containing the compound, and methods of making and using the compound are provided.

公开(公告)号：US10414894B2

公开(公告)日：2019-09-17

申请号：US15500376

申请日：2015-07-31

Applicant: Virginia Commonwealth University

Inventor： Massimo Bertino

IPC: C08J9/28 ,  B01J3/00 ,  C01B33/158 ,  B01J13/00 ,  C08L33/08

Abstract: A method of synthesizing aerogels and cross-linked aerogels in a single step and in a single pot without requiring any solvent exchange is described. Porous matrices are synthesized through a modification of hydrolysis condensation of alkoxides in which addition of water is minimized. The reaction occurs in an ethanol-water azeotrope mixture; the water in the azeotrope slowly hydrolyzes the alkoxide. Additionally, after gelation, the porous matrix is dried in supercritical ethanol rather than liquid CO2, which allows for elimination of solvent exchange steps. These modifications allow for the preparation of aerogel monoliths in any size in one step and in one pot and much faster than conventional procedures. In addition, the method provides for custom aerogel parts with large dimensions, as well as high volume fabrication of aerogels. The custom aerogel parts may be used in a variety of thermal insulation applications.

公开(公告)号：US20190256483A1

公开(公告)日：2019-08-22

申请号：US16318590

申请日：2017-07-24

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin K. SAFO ,  Guoyan XU ,  Yan ZHANG ,  Osheiza ABDULMALIK

IPC: C07D307/46 ,  C07F9/655 ,  A61P7/00 ,  A61P43/00

Abstract: Prodrugs and derivatives of 5-hydoxymethyl-2-furfural (5-HMF) with protected or modified aldehyde and/or alcohol moieties are provided. The prodrugs or derivatives exhibit increased bioavailability, e.g. due to having extended half-lives in circulation. The drugs are therefore administered i) at lower doses and/or ii) less frequently than 5-HMF, while still maintaining the beneficial therapeutic effects of 5-HMF.

公开(公告)号：US10314870B2

公开(公告)日：2019-06-11

申请号：US14650775

申请日：2013-12-10

Applicant: Virginia Commonwealth University

Inventor： Paul Fisher ,  Devanand Sarkar ,  Paul Dent

IPC: A61K35/768 ,  A61K39/00 ,  C12N15/86 ,  A61K31/166 ,  A61K31/404 ,  A61K45/06 ,  C12N7/00

Abstract: A tropism modified cancer terminator virus (Ad.5/3-CTV; Ad.5/3-CTV-M7) has been found to have infectivity that is Coxsackie Adenoviral Receptor (CAR) independent. The Ad.5/3-CTV (Ad.5/3-CTV-M7) may be used alone or in combination with other therapeutic agents such as agents that augment reactive oxygen (ROS) production, HDAC inhibitors, MCL-1 inhibitors and Bcl-2 inhibitors to treat a variety of cancers particularly including malignant glioma (GBM), renal cancer, prostate cancer, and colorectal cancer.

公开(公告)号：US10314857B2

公开(公告)日：2019-06-11

申请号：US14790568

申请日：2015-07-02

Applicant: Virginia Commonwealth University

Inventor： Joseph D. Roderique

IPC: A61K31/714 ,  A61K9/00 ,  A61K47/22 ,  A61J1/05 ,  A61J1/20

Abstract: Compositions, methods and kits for treating victims of carbon monoxide and/or cyanide poisoning and/or nitric acid-induced vasoplagia are provided. The compositions comprise reduced forms of Vitamin B12 such as reduced hydroxocobalamin or reduced cobinamide, and typically comprise at least one reducing agent (e.g. ascorbic acid). The compositions are generally produced, stored and delivered under reducing, usually anaerobic, conditions in order to preserve the desired oxidation state when introduced into the blood stream of a recipient.