公开(公告)号：US10203298B2

公开(公告)日：2019-02-12

申请号：US15144024

申请日：2016-05-02

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Sridhar G. Iyengar

IPC: G01N27/327 ,  G01N27/403 ,  C12Q1/00 ,  G01N27/30

Abstract: Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet.

公开(公告)号：US20180249938A1

公开(公告)日：2018-09-06

申请号：US15910251

申请日：2018-03-02

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding

IPC: A61B5/1486 ,  C12Q1/00 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7225 ,  C12Q1/001 ,  C12Q1/006

Abstract: Correction for initial variation in thickness of a polymer layer and for changes in the coating thickness that occur after implantation of a biosensor and therefore provides substantial increase in the accuracy and lifetime of implantable sensors is done using a factor derived from the decay of potential.

公开(公告)号：US09907501B2

公开(公告)日：2018-03-06

申请号：US15069071

申请日：2016-03-14

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding

IPC: A61B5/00 ,  A61B5/1486 ,  C12Q1/00 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7225 ,  C12Q1/001 ,  C12Q1/006

Abstract: Correction for initial variation in thickness of a polymer layer and for changes in the coating thickness that occur after implantation of a biosensor and therefore provides substantial increase in the accuracy and lifetime of implantable sensors is done using a factor derived from the decay of potential.

公开(公告)号：US09857324B2

公开(公告)日：2018-01-02

申请号：US14987895

申请日：2016-01-05

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

IPC: G01N27/327 ,  C12Q1/00 ,  G01N27/30

CPC classification number: G01N27/3274 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3273

Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

公开(公告)号：US09709519B2

公开(公告)日：2017-07-18

申请号：US14816786

申请日：2015-08-03

Applicant: AGAMATRIX, INC.

Inventor： Ian Harding ,  Sridhar G. Iyengar ,  Baoguo Wei ,  Steven Diamond ,  Martin Forest

IPC: G01N33/49 ,  G01N27/403 ,  G01N27/28 ,  G01N27/327 ,  G01N33/50

CPC classification number: G01N27/28 ,  G01N27/3271 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/403 ,  G01N33/50

Abstract: The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.

公开(公告)号：US09632056B2

公开(公告)日：2017-04-25

申请号：US14964756

申请日：2015-12-10

Applicant: AgaMatrix, Inc.

Inventor： Sridhar Iyengar ,  Ian Harding ,  Charles Boiteau ,  Colin Butters

IPC: G01N27/327 ,  G01N21/77 ,  G01N21/84 ,  G01N33/487 ,  G01N21/25 ,  G01J1/42

CPC classification number: G01N27/3272 ,  G01J1/42 ,  G01N21/255 ,  G01N21/7703 ,  G01N21/8483 ,  G01N27/327 ,  G01N27/3273 ,  G01N33/48707 ,  G01N33/48771 ,  G01N2201/08

Abstract: A test strip with an incorporated optical waveguide and deflectors punched through the optical waveguide allows light to exit through a layer of the test strip and be detected by a photo detector. Using light and a photodetector, these uniquely coded strips are identified. The waveguide can be constructed by sandwiching two layers of the test strip around a light transmissible layer. This configuration allows light to be transmitted through the test strip and out the other end, as well as allowing some light to escape the deflector. This light is detected by a photodetector mounted in the analyte test meter. The deflectors may be placed in patterns such that detection of this light indicates certain characteristics of the strip, such as non-counterfeit, regional identification, type of analyte tested, and coding information.

公开(公告)号：US20160231321A1

公开(公告)日：2016-08-11

申请号：US15017787

申请日：2016-02-08

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Sridhar Iyengar ,  Richard Williams

IPC: G01N33/573 ,  G01N27/416

CPC classification number: G01N33/573 ,  C12Q1/001 ,  G01N27/4166 ,  G01N33/5438 ,  G01N2333/90 ,  G01N2333/902

Abstract: A method and apparatus for electrochemical detection of analyte in a sample makes use of a binding interaction and relies on the discovery that asymmetric distribution of a redox enzyme between two electrodes that occurs when a redox enzyme-containing reagent is immobilized at the surface of one electrode can be detected as a chemical potential gradient arising from an asymmetry in the distribution of oxidized or reduced redox substrate. This chemical potential gradient can be detected potentiometrically by observing the potential difference between the electrodes in an open circuit, or amperometrically by observing the current flow between the electrodes when the circuit is closed. In both cases, the observation of asymmetry can be done without the application of an external potential or current to the electrodes.

Abstract translation: 用于样品中分析物的电化学检测的方法和装置利用结合相互作用，并且依赖于以下发现：当在含有氧化还原酶的试剂固定在一个电极的表面时发生的氧化还原酶在两个电极之间的不对称分布 可以被检测为由氧化还原氧化还原底物的分布不对称引起的化学势梯度。 可以通过在断路中观察电极之间的电势差，或者当电路闭合时通过观察电极之间的电流来进行电流分析来电位检测该化学势梯度。 在这两种情况下，可以在不对电极施加外部电位或电流的情况下进行不对称性的观察。

公开(公告)号：US20160209357A1

公开(公告)日：2016-07-21

申请号：US14988264

申请日：2016-01-05

Applicant: AgaMatrix, Inc.

Inventor： Steven Diamond ,  Ian Harding ,  Sridhar G. Iyengar ,  Baoguo Wei

IPC: G01N27/416 ,  G01N33/487 ,  G01N27/327

CPC classification number: G01N27/4166 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/4161 ,  G01N33/48707

Abstract: A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.

公开(公告)号：US20160169828A1

公开(公告)日：2016-06-16

申请号：US14987895

申请日：2016-01-05

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

IPC: G01N27/327

CPC classification number: G01N27/3274 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3273

Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

公开(公告)号：US09267910B2

公开(公告)日：2016-02-23

申请号：US14473182

申请日：2014-08-29

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Sridhar G. Iyengar ,  Baoguo Wei ,  Steven Diamond ,  Martin Forest

IPC: G01N33/50 ,  G01N27/403 ,  G01N27/416 ,  G01N27/28 ,  G01N27/327

CPC classification number: G01N27/28 ,  G01N27/3271 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/403 ,  G01N33/50

Abstract: The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.

Abstract translation: 在电流测量和电位测量之间切换的能力在执行未知数的分析方面提供了极大的灵活性。 装置和方法可以提供这种切换以从电化学电池收集数据。 细胞可以含有用于测量人血液中的葡萄糖的试剂。