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41.发明授权公开(公告)号：US11465160B2
公开(公告)日：2022-10-11
申请号：US16327358
申请日：2017-09-15
Applicant: Fenwal, Inc.
Inventor： Kyungyoon Min , Benjamin E. Kusters , Richard I. Brown , Mark J. Brierton
Abstract: Systems and methods are provided for separating blood into two or more components. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit incorporated into a common case, which allows for fluid separation by two different methods. Depending on the separation procedure to be carried out, the fluid flow circuit paired with the blood separation device may include only one separation chamber configured to be mounted to the centrifugal separator or spinning membrane separator drive unit or two separation chambers, with one being mounted to the centrifugal separator and the other to the spinning membrane separator drive unit. The system may be used to separate and collect any combination of red blood cells, plasma, and platelets.
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公开(公告)号：US11325321B2
公开(公告)日：2022-05-10
申请号：US17147660
申请日：2021-01-13
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
Abstract: Method and apparatus are disclosed for mechanically opening a heat-bonded connection site between two hollow, flexible, thermoplastic segments of a medical fluid flow path, the heat-bonded connection site having an axis. The connection site is compressed between two facing surfaces, and the facing surfaces are relatively moved to rotate the connection site about the connection site axis and to apply force to the connection site substantially perpendicular to the connection site axis.
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公开(公告)号：US11311823B2
公开(公告)日：2022-04-26
申请号：US16807233
申请日：2020-03-03
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
Abstract: Blood in a separation chamber is separated into a red blood cell layer, a plasma constituent, and a mononuclear cell-containing layer. A portion of the plasma constituent exits the chamber via a plasma outlet, while a first portion of the red blood cell layer exits via a red blood cell outlet. A second portion of the red blood cell layer exits the chamber via the red blood cell outlet and is collected. At least a portion of the collected red blood cell layer may then be conveyed to the chamber via the red blood cell outlet to convey at least a portion of the mononuclear cell-containing layer out of the chamber via the plasma outlet for collection. A second portion of the plasma constituent may be conveyed out of the chamber via the plasma outlet to more fully collect the mononuclear cell-containing layer without the use of collected plasma.
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44.发明授权公开(公告)号：US11291953B2
公开(公告)日：2022-04-05
申请号：US16869968
申请日：2020-05-08
Applicant: Fenwal, Inc.
Inventor： Richard I. Brown , Benjamin E. Kusters , Kyungyoon Min
Abstract: A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.
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公开(公告)号：US20210106747A1
公开(公告)日：2021-04-15
申请号：US17128377
申请日：2020-12-21
Applicant: Fenwal, Inc.
Inventor： Christopher J. Wegener , Benjamin E. Kusters
Abstract: The present disclosure relates to systems and methods for the separation of blood into blood products and, more particularly, to systems and methods that permit automated recovery of white blood cells after producing a leukocyte-reduced blood product.
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Patent Agency Ranking
公开(公告)号：US10918780B2
公开(公告)日：2021-02-16
申请号：US16108471
申请日：2018-08-22
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters
Abstract: A computer-implemented method for controlling fluid flow rates during a biological fluid procedure, comprising providing a membrane separator configured to separate a biological fluid into filtrate and retentate, wherein concentration of retentate exiting the membrane separator is controllable by altering a flow rate of the retentate exiting the membrane separator. The computer-implemented method also comprises detecting a change of attenuated retentate particles within the filtrate, comparing the change of attenuated retentate particles within the filtrate with a threshold level, and providing a response action comprising altering the concentration of retentate exiting the membrane separator if the change of attenuated retentate particles within the filtrate exceeds the threshold level.
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47.发明授权公开(公告)号：US10890524B2
公开(公告)日：2021-01-12
申请号：US16429128
申请日：2019-06-03
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters
IPC: G01N21/25 , A61M1/36 , G01N21/3577 , G01N21/359 , G01N33/49
Abstract: An optical sensor device includes a light source configured to emit a light including a wavelength in a range of 650 to 900 nm that is exposed to a biological fluid at first and second times. At least a portion of the light is reflected off of the fluid and received by a light detector. The light detector analyzes at least a portion of the received light to determine a first intensity of the light at the wavelength at the first time and a second intensity of the light at the wavelength at the second time. A controller compares the first and second intensities and generates an output indicative of the presence of red blood cells or free hemoglobin in the biological fluid depending on which intensity is greater and whether there is more redness in the biological fluid at the first time or at the second time.
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公开(公告)号：US20190060547A1
公开(公告)日：2019-02-28
申请号：US16108471
申请日：2018-08-22
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters
Abstract: A computer-implemented method for controlling fluid flow rates during a biological fluid procedure, comprising providing a membrane separator configured to separate a biological fluid into filtrate and retentate, wherein concentration of retentate exiting the membrane separator is controllable by altering a flow rate of the retentate exiting the membrane separator. The computer-implemented method also comprises detecting a change of attenuated retentate particles within the filtrate, comparing the change of attenuated retentate particles within the filtrate with a threshold level, and providing a response action comprising altering the concentration of retentate exiting the membrane separator if the change of attenuated retentate particles within the filtrate exceeds the threshold level.
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公开(公告)号：US10143829B2
公开(公告)日：2018-12-04
申请号：US15248139
申请日：2016-08-26
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
IPC: A61M39/14 , A61M39/18 , B26F1/26 , B29C65/02 , B29C65/76 , B29C65/82 , G01M3/28 , B26F3/00 , F16L13/00 , A61M39/08 , B29C65/00 , B29C65/74 , B29C65/78 , B29C65/04
Abstract: System, apparatus and method for opening a heat-bonded connection formed between two hollow, flexible thermoplastic conduits. A pressure difference is created between the inside of at least one of the conduits and the ambient atmosphere sufficient to cause expansion of a wall of the tubing conduit in the vicinity of a frangible portion at least partially blocking the connection to disrupt the frangible portion and reduce the blocking.
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公开(公告)号：US10046278B2
公开(公告)日：2018-08-14
申请号：US15482248
申请日：2017-04-07
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
Abstract: Methods for controlling a spinning membrane separator so as to limit fouling of the membrane by changing the rotation rate of the spinning membrane in response to the fouling rate, while maintaining a constant outlet cellular concentration. Increasing the spinner rotation rate will increase the strength of the Taylor vortices generated within the separator by the spinning of the membrane, which should reduce fouling of the membrane. The goal of the method is to rotate the spinning membrane at the slowest rate possible without unacceptable fouling. Two specific methods to control fouling are disclosed. In a first, unidirectional method, the spin rate of the membrane is only increased in response to undesirable fouling in order to prevent the fouling from continuing. In a second, bidirectional method, the spin rate of the membrane may be either increased or decreased in response to the measured fouling rate in order to maintain the fouling rate within a desired range.
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