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公开(公告)号：US20160296691A1
公开(公告)日：2016-10-13
申请号：US15189752
申请日：2016-06-22
Applicant: Fenwal, Inc.
Inventor： Kyungyoon Min , Katherine Radwanski
CPC classification number: A61M1/3681 , A61M1/30 , A61M1/3455 , A61M1/3496 , A61M1/3683 , A61M1/3686 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B04B11/02
Abstract: Systems and methods for performing online extracorporeal photopheresis of mononuclear cells are disclosed. Whole blood is removed from a patient and introduced through a processing set into a separation chamber to separate the desired cell population from the blood. The separated cell population is processed through the set which is associated with a treatment chamber where the cells are treated. Once treated, the cells are returned to the patient. The processing set remains connected to the patient during the entire ECP treatment procedure and provides an online, sterile closed pathway between the separation chamber and the treatment chamber.
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42.发明申请SYSTEMS AND METHODS FOR ACHIEVING TARGET POST-PROCEDURE FRACTION OF CELLS REMAINING, HEMATOCRIT, AND BLOOD VOLUME DURING A THERAPEUTIC RED BLOOD CELL EXCHANGE PROCEDURE WITH OPTIONAL ISOVOLEMIC HEMODILUTION 有权在治疗性红血球细胞交换程序期间用于实现可选的ISOVOLEMIC HEMODILUTION的实现靶细胞的剩余，HEMATOCRIT和血液体积的目标后续程序分类的系统和方法公开(公告)号：US20160296688A1
公开(公告)日：2016-10-13
申请号：US15184492
申请日：2016-06-16
Applicant: Fenwal, Inc.
Inventor： Daniel R. Boggs , Kyungyoon Min , Lan T. Nguyen , John T. Foley , Brian C. Case
CPC classification number: A61M1/3455 , A61M1/342 , A61M1/3437 , A61M1/3458 , A61M1/3496 , A61M1/3672 , A61M1/38 , A61M1/385 , A61M2205/3334 , A61M2205/505 , A61M2205/52 , A61M2230/005 , A61M2230/207 , G06F19/00
Abstract: Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.
Abstract translation: 公开了用于进行治疗性红细胞交换程序的系统和方法。 一方面，一种系统包括用于使来自患者的全血流动的第一流动路径。 分离器与第一流路连通，用于从血浆中分离至少红细胞。 第二和第三流动路径与分离器连通，用于分离从分离器流出分离的血浆和红细胞。 流量控制器与流动路径相关联，以控制流动路径之间的流体连通。 控制器被配置为基于操作者输入的数据执行完成过程完成时实现剩余的患者细胞的目标部分，目标血细胞比容和目标患者流体体积变化的过程。
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公开(公告)号：US20160279316A1
公开(公告)日：2016-09-29
申请号：US15177426
申请日：2016-06-09
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Kyungyoon Min , Christopher Wegener , William H. Cork
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A method and system for collecting a double volume of red blood cells using a spinning membrane separator is provided by which a first quantity of whole blood is withdrawn from a donor; a first quantity of whole blood is flowed to the spinning membrane separator; where it is separated into a first quantity of red blood cells and a first quantity of plasma. The first quantity of red blood cells and the first quantity of plasma are then flowed to respective collection containers, and at least a portion of the first quantity of plasma is returned to the donor. A second quantity of whole blood withdrawn from the donor, and then separated into a second quantity of red blood cells and a second quantity of plasma using the spinning membrane separator. The second quantity of red blood cells and the second quantity of plasma are then flowed to the respective collection containers, and at least a portion of the second quantity of plasma is returned to the donor.
Abstract translation: 提供使用纺丝膜分离器收集双倍体积的红细胞的方法和系统，通过该方法和系统从供体中取出第一量的全血; 第一量的全血流入纺丝膜分离器; 其中它被分成第一量的红细胞和第一量的血浆。 然后将第一数量的红细胞和第一量的血浆流入相应的收集容器，并且将第一量的等离子体的至少一部分返回给供体。 从供体排出的第二量全血，然后使用纺丝膜分离器分离成第二量的红细胞和第二量的血浆。 然后将第二数量的红细胞和第二量的血浆流到相应的收集容器，并且将第二量的等离子体的至少一部分返回给供体。
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44.发明申请公开(公告)号：US20160184504A1
公开(公告)日：2016-06-30
申请号：US15066047
申请日：2016-03-10
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Kyungyoon Min , Christopher Wegener
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
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公开(公告)号：US09279104B2
公开(公告)日：2016-03-08
申请号：US14625024
申请日：2015-02-18
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Christopher Wegener , Kyungyoon Min
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A blood processing system and method are disclosed that comprise a leukoreduction filter for removing leukocytes from red blood cells as the red blood cells pass through the filter; and a pump for pumping an additive solution through the leukoreduction filter to flush the leukoreduction filter of red blood cells that remain in the leukoreduction filter after filtration of the red blood cells. Additive solution is flowed through the leukoreduction filter at an initial flush rate to flush remaining red blood cells from the leukoreduction filter and the pump increases the flush rate of the additive solution during flushing of the leukoreduction filter.
Abstract translation: 公开了一种血液处理系统和方法，所述血液处理系统和方法包括当红细胞通过过滤器时从红细胞中除去白细胞的白细胞减退过滤器; 以及用于泵送添加剂溶液通过白细胞减退过滤器以冲洗过滤红细胞后残留在白细胞减少过滤器中的红细胞的白细胞减少过滤器的泵。 添加剂溶液以初始冲洗速率流过白细胞减少过滤器，以从白细胞减少过滤器中冲洗剩余的红细胞，并且泵增加白细胞减少过滤器冲洗期间添加剂溶液的冲洗速率。
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Patent Agency Ranking
公开(公告)号：US20150367569A1
公开(公告)日：2015-12-24
申请号：US14309305
申请日：2014-06-19
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
IPC: B29C65/00
CPC classification number: B29C66/857 , A61M39/14 , A61M39/146 , A61M39/18 , B29C65/04 , B29C65/203 , B29C65/2046 , B29C65/743 , B29C65/7802 , B29C65/7841 , B29C66/02241 , B29C66/1142 , B29C66/5221 , B29C66/71 , B29C66/7373 , B29C66/73921 , B29C66/81431 , B29C66/81871 , B29C66/8221 , B29C66/8324 , B29L2023/007 , Y10T156/1751 , B29K2027/06
Abstract: System, method and apparatus for making a plurality of sterile connections between a plurality of pairs of thermoplastic tubes. A first receiver receives a first tube, a second receiver receives second and third tubes, and a third receiver receives a fourth tube. The first and second receivers are movable to place clamped and heated ends of first and second tubes into contact and the second and third receivers are movable to place clamped and heated ends of third and fourth tubes into contact.
Abstract translation: 用于在多对热塑性管之间进行多个无菌连接的系统，方法和装置。 第一接收器接收第一管，第二接收器接收第二和第三管，第三接收器接收第四管。 第一和第二接收器是可移动的，以将第一和第二管的夹紧和加热的端部接触，并且第二和第三接收器可移动以将第三和第四管的夹紧和加热的端部接触。
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47.发明申请公开(公告)号：US20150166957A1
公开(公告)日：2015-06-18
申请号：US14625121
申请日：2015-02-18
Applicant: Fenwal, Inc.
Inventor： Benjamin Kusters , Christopher Wegener , Kyungyoon Min
CPC classification number: A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
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48.发明申请RED BLOOD CELL PRODUCTS AND THE STORAGE OF RED BLOOD CELLS IN CONTAINERS FREE OF PHTHALATE PLASTICIZER 审中-公开红血球细胞产物和红血球细胞储存在不含PHTHALATE PLASTICIZER的容器中公开(公告)号：US20140091047A1
公开(公告)日：2014-04-03
申请号：US14122847
申请日：2012-09-19
Applicant: Fenwal, Inc.
Inventor： Katherine Radwanski , Craig L. Sanford , Kyungyoon Min , Bryan Blickhan , Daniel Lynn , Tat Mui
CPC classification number: A61J1/10 , A01N1/0226 , A01N1/0263 , A01N1/0273 , A61J1/1468 , A61K35/18 , A61K45/06 , B32B27/08 , B32B27/304 , B32B27/32 , B32B2270/00 , B32B2307/7244 , B32B2439/80
Abstract: Red blood cell products and compositions are disclosed. The product includes a container made from PVC or a non-PVC material that is substantially free of a phthalate plasticizer but otherwise includes one or more non-phthalate plasticizers or extractable agents. The product includes a RBC concentrate which has been combined with an additive solution for storing the RBCs.
Abstract translation: 公开了红细胞产品和组合物。 该产品包括由PVC制成的容器或非PVC材料，其基本上不含邻苯二甲酸酯增塑剂，但另外包括一种或多种非邻苯二甲酸酯增塑剂或可提取剂。 该产品包括与用于储存RBC的添加剂溶液组合的RBC浓缩物。
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49.发明申请RED BLOOD CELL PRODUCTS AND THE STORAGE OF RED BLOOD CELLS IN NON-PVC CONTAINERS 审中-公开红血球细胞产物和红血球细胞在非聚氯乙烯容器中的储存公开(公告)号：US20140086892A1
公开(公告)日：2014-03-27
申请号：US14122834
申请日：2012-09-19
Applicant: FENWAL, INC.
Inventor： Kyungyoon Min , Katherine Radwanski , Craig L. Sandford
IPC: A61K35/18
CPC classification number: A61K35/18 , A01N1/0226 , A01N1/0263 , A61J1/10 , B32B27/08 , B32B2439/80
Abstract: Red blood cell products are disclosed. The product includes a container made from a non-PVC, substantially plasticizer-free material. The product includes a RBC concentrate and a hypotonic solution for storing the RBCs.
Abstract translation: 公开红细胞产品。 该产品包括由非PVC，基本上不增塑剂的材料制成的容器。 该产品包括RBC浓缩物和用于储存RBC的低渗溶液。
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公开(公告)号：US20130334420A1
公开(公告)日：2013-12-19
申请号：US13788164
申请日：2013-03-07
Applicant: FENWAL, INC.
Inventor： Kyungyoon Min , Benjamin Kusters , Christopher Wegener
IPC: G01N33/49
CPC classification number: G01N33/49 , A61B5/14535 , A61B5/14557 , G01N21/3577
Abstract: A separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, including prediction of the hematocrit of the whole blood using a light source and an optical sensor.
Abstract translation: 公开了一种分离装置以及在血液处理程序中采用该装置的系统和方法。 在一个实施例中，提供了一种旋转膜分离器。 公开了用于将先前收集的全血的单位分离成选定的血液成分（例如浓缩红细胞和血浆）的自动化系统和方法，包括使用光源和光学传感器预测全血的血细胞比容。
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