Abstract:
An apparatus for transferring receptacles between a plurality of receptacle-receiving structures disposed at different locations adjacent a transport track. The apparatus includes a receptacle carrier operatively engaged with the transport track and adapted to carry a receptacle and translate along the transport track. The receptacle carrier is further adapted to selectively stop at a transfer station with respect to any of the receptacles-receiving structures. The receptacle carrier includes a receptacle moving mechanism adapted to move a receptacle with respect to the receptacle carrier to move a receptacle into and/or out of the receptacle carrier. The apparatus further includes a transfer position locating system to automatically determine a location of a transfer position of the receptacle carrier with respect to each of the receptacle-receiving structures, thereby enabling the receptacle carrier to transfer a receptacle between the receptacle carrier and the receptacle-receiving structures.
Abstract:
A system including a housing, a sample rack for holding a plurality of sample receptacles, and a reader for reading two-dimensional machine-readable labels associated with the plurality of sample receptacles as the sample rack moves between first and second positions within the housing. The system further includes a processing and control unit adapted to decode the two-dimensional machine-readable labels read by the reader and to associate each of the decoded two-dimensional machine-readable labels with an associated sample receptacle based on a measured position of the sample rack when the two-dimensional machine-readable label was read.
Abstract:
A mechanism for positioning a fluid container supported on a movable carrier at a predetermined location comprises a container positioning ramp located adjacent to a portion of the moveable carrier and a container hold down arm. The container positioning ramp is configured to be contacted by a bottom portion of a container supported on the movable carrier when the movable carrier moves the container to the predetermined location. The container hold down arm is configured for selective movement relative to the container positioned at the predetermined location and is configured to contact a top portion of the container positioned at the predetermined location and push the container down so that the bottom portion of the container maintains contact with the container positioning ramp.
Abstract:
A mechanism for performing capacitive level sensing of fluid within a fluid container supported on a movable carrier comprises a conductive probe, a probe position sensor, and a movable grounding element. The probe is configured for capacitive level sensing by detecting a signal or change of signal based on capacitance when the probe, or a conductive tip removably attached to the probe, contacts the surface of the fluid within the container. The probe position sensor is for monitoring a vertical position of the probe and recording the position at which the signal or change of signal is detected. The movable grounding element is configured for selective movement relative to a container positioned by the movable carrier at a level-sensing location with respect to the probe until the grounding element is in close proximity to or in contact with a portion of the container.
Abstract:
An apparatus for incubating the contents of a plurality of receptacles and for detecting a signal emitted by the contents of each of the receptacle includes a plurality of receptacle holders configured to incubate the contents of each a plurality of receptacles held by each of the receptacle holders. A controller is coupled to each of the receptacle holders and is configured to independently control an incubation temperature of each of the receptacle holders to independently control a temperature at which the receptacles held by each of the receptacle holders is incubated. At least one signal detector is configured to detect a signal emitted by the contents of each of the receptacles held in each of the receptacle holders, and a signal detector indexer is configured to successively optically couple each signal detector with each of the receptacles held in each of the receptacle holders to detect optical emissions from each successively coupled receptacle.
Abstract:
An input module includes a carrier shelf for supporting a receptacle carrier, a retrieval dock configured to receive one receptacle from a carrier supported on the carrier shelf and present the receptacle for removal by a receptacle transport apparatus, and a pusher configured to push receptacles on the carrier to one end of the carrier and to push one receptacle at a time off the end of the carrier and onto the retrieval dock. A method for determining a number of receptacles on a carrier includes placing the carrier on a carrier shelf, pushing receptacles on the carrier to one end of the carrier with a packer, detecting a position of the packer the receptacles have been pushed to the end of the carrier, and determining the number of receptacles on the carrier from the position of the packer. A method for packing receptacles supported by a carrier comprises placing the carrier on a carrier shelf, contacting an end-most one of the receptacles on the carrier with a packer comprising a packer carriage and a contact portion projecting from the packer carriage, and pushing the receptacles to one end of the carrier with the packer.
Abstract:
An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder that includes multiple receptacle wells. Each well can receive a receptacle and has a through-hole extending from an inner surface of the well to an outer surface of the holder. The apparatus includes multiple optical fibers, and each optical fiber has a first end in optical communication with an associated well and a second end in optical communication with an excitation signal source and/or an emission signal detector. The first end of each optical fiber is moveable with respect to the through-hole. A cover is movable between an open position and a closed position relative to the receptacle holder, and the first end of each optical fiber moves with respect to the through-hole of the associated well as the cover moves to the open or closed position or when the cover moves into or out of contact with any receptacles within the wells.
Abstract:
An apparatus including a thermally-conductive receptacle holder having a row of receptacle wells. Each receptacle well has an inner surface defined to receive a receptacle, and each receptacle well has a through-hole extending between the inner and outer surfaces thereof. The apparatus further includes one or more thermal elements for altering a temperature(s) of the receptacle holder, where the one or more thermal element are in contact with a side surface of the receptacle holder. There are two or more thermistors disposed in contact with the receptacle holder and a channel disposed within the side surface and containing wires and/or electrical connections for the two or more thermistors. The apparatus additionally includes a plurality of optical fibers, each optical fiber providing optical communication between one of the receptacle wells and at least one of an excitation signal source and an emission signal detector, where a first end of each optical fiber is disposed outside, within, or extends through the through-hole of a corresponding one of the receptacle wells, and where a second end of each optical fiber is in optical communication with the excitation signal source and/or the emission signal detector.
Abstract:
An apparatus for transporting groups of consumables between vertically spaced holding shelves that includes a support chassis laterally spaced from the holding shelves, a transport elevator coupled to the support chassis, a lift platform, and a scissors actuator connecting the lift platform to the support chassis and configured to laterally translate the lift platform between a first position laterally aligned with the support chassis and a second position laterally aligned with one of the holding shelves.
Abstract:
A system includes a reagent pack input carousel, a carousel frame supporting the carousel, and a track on which the carousel frame is supported for movement of the carousel into and out of an instrument in drawer-like fashion. The carousel is rotatable about an axis of rotation and includes a plurality of reagent pack input stations arranged about the perimeter of the carousel. Each input station is adapted to carry a reagent pack, and the input stations are oriented at an angle with respect to a radial orientation relative to the axis of rotation. Each input station includes an alignment block located at a radially inner end of the station, and the block is received within a recess formed in an end of the reagent pack placed in the station to align and position of the reagent pack within the station.