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    FLUID CONTAINER MANAGEMENT SYSTEM
    2.
    发明公开
    FLUID CONTAINER MANAGEMENT SYSTEM 审中-公开

    公开(公告)号：US20240295575A1

    公开(公告)日：2024-09-05

    申请号：US18659963

    申请日：2024-05-09

    Applicant: Gen-Probe Incorporated

    Inventor： David A. BUSE ,  Norbert D. HAGEN ,  David OPALSKY

    IPC: G01N35/04 ,  B65G29/00 ,  B65G47/84 ,  G01F23/263

    CPC classification number: G01N35/04 ,  B65G29/00 ,  B65G47/84 ,  G01F23/268 ,  G01N2035/0441

    Abstract: A mechanism for providing selective access to one of a plurality of containers within a substantially enclosed housing comprises a movable carrier within the housing, a container access opening formed in a top wall of the housing, and a shutter plate attached to the top wall of the housing. The carrier is configured to hold and carry the plurality of containers. The container access opening is formed at a position on a path traversed by the plurality of containers carried on the carrier so that movement of the carrier sequentially places each of the plurality of containers beneath the container access opening. The shutter plate is pivotable between a first position covering the container access opening to thereby prevent access to the container located beneath the opening and a second position exposing the opening to thereby allow access to the container located beneath the opening.

    SYSTEM AND METHOD FOR MONITORING A REACTION WITHIN A RECEPTACLE VESSEL
    4.
    发明申请
    SYSTEM AND METHOD FOR MONITORING A REACTION WITHIN A RECEPTACLE VESSEL 审中-公开

    公开(公告)号：US20200319107A1

    公开(公告)日：2020-10-08

    申请号：US16910414

    申请日：2020-06-24

    Applicant: Gen-Probe Incorporated

    Inventor： Haitao LI ,  David OPALSKY ,  R. Eric HEINZ ,  Norbert D. HAGEN

    IPC: G01N21/64 ,  G01N21/27

    Abstract: A system for monitoring reactions with a plurality of receptacle vessels that includes: an incubator; a movable receptacle carrier contained within a temperature-controlled chamber of the incubator; one or more fixed fluorometers configured to measure a fluorescent emission and positioned with respect to the receptacle carrier to measure fluorescent emissions from receptacle vessels carried on the receptacle carrier into an operative position with respect to each fluorometer; one or more fluorescent reference standards mounted on the receptacle carrier; and a controller configured to control operation of the receptacle carrier and the one or more fluorometers to determine if a fluorescent emission intensity of one or more of the fluorescent reference standards deviates from an expected fluorescent emission intensity.

    METHOD OF MEASURING A TIME-VARYING SIGNAL EMISSION
    5.
    发明申请
    METHOD OF MEASURING A TIME-VARYING SIGNAL EMISSION 审中-公开

    公开(公告)号：US20190079248A1

    公开(公告)日：2019-03-14

    申请号：US16179609

    申请日：2018-11-02

    Applicant: GEN-PROBE INCORPORATED

    Inventor： Norbert D. HAGEN ,  David OPALSKY

    IPC: G02B6/36 ,  G02B6/06 ,  G02B6/08 ,  G01N21/25 ,  G01N21/64 ,  G02B6/42

    Abstract: A method of measuring a time-varying signal emission, the method including subjecting the contents of a receptacle to a thermal cycling process. During the thermal cycling process, measuring a signal emission from the contents of the receptacle at regular time intervals and recording the measured signal emission and a time stamp at each time interval. Also during the thermal cycling process, determining a temperature of the thermal cycling process at regular time intervals and recording the determined temperature and a time stamp at each time interval. The measured signal emissions are synchronized with a specific temperature of the thermal cycling process by comparing the time stamps of the measured emission signals with the time stamps of the determined temperatures.

    USE OF A FLUORESCENT MATERIAL TO DETECT FAILURE OR DETERIORATED PERFORMANCE OF A FLUOROMETER
    6.
    发明申请
    USE OF A FLUORESCENT MATERIAL TO DETECT FAILURE OR DETERIORATED PERFORMANCE OF A FLUOROMETER 审中-公开

    公开(公告)号：US20180180544A1

    公开(公告)日：2018-06-28

    申请号：US15902657

    申请日：2018-02-22

    Applicant: Gen-Probe Incorporated

    Inventor： Haitao LI ,  David OPALSKY ,  R. Eric HEINZ ,  Norbert D. HAGEN

    IPC: G01N21/64 ,  G01N21/27

    Abstract: A System and method for self-checking a fluorometer for failure or deteriorated performance includes fluorescent reference standards mounted on a support to move with respect to one or more fixed fluorometers. The intensity of the fluorescent emission of the fluorescent reference standard is initially measured with the fluorometer, and, after a prescribed interval of usage of the fluorometer, a test measurement of the intensity of the fluorescent emission of the fluorescent standard is taken with the fluorometer. The test measurement is compared to the initial measurement, and failure or deteriorated performance of the fluorometer is determined based on a deviation of the test measurement from the initial measurement.

    AUTOMATED METHOD FOR ANALYZING SAMPLES
    7.
    发明申请
    AUTOMATED METHOD FOR ANALYZING SAMPLES 审中-公开

    公开(公告)号：US20170335373A1

    公开(公告)日：2017-11-23

    申请号：US15675206

    申请日：2017-08-11

    Applicant: Gen-Probe Incorporated

    Inventor： David A. BUSE ,  David OPALSKY ,  Jason F. RHUBOTTOM ,  Norbert D. HAGEN ,  Jennifer L. TIDD

    IPC: C12Q1/68 ,  B01L3/00 ,  B01L7/00 ,  G01N35/04

    Abstract: An automated method for analyzing a plurality of samples within a housing of a self-contained system. The system is loaded with a plurality of samples, after which a first assay is performed on a first sample subset and a second assay performed on a second sample subset. The two assays include exposing the samples to a target capture reagent having a solid support for directly or indirectly immobilizing a target nucleic acid that may be present in one or more of the samples. The two assays may be performed with the same or different target capture reagents and target nucleic acids, but the receptacles for performing the exposing step have substantially identical geometries. Following the exposing step, an amplification reaction for amplifying a region of the target nucleic acid is performed with each sample. The amplification reactions of the two assays are performed in receptacles having different geometries.

    METHODS AND DEVICES EMPLOYING THERMOPLASTICS FROM THE POLYARYLETHERKETONE (PAEK) FAMILY OF SEMI-CRYSTALLINE THERMOPLASTICS FOR CALIBRATION AND/OR MONITORING OF OPTICAL MEASUREMENT DEVICES
    8.
    发明申请
    METHODS AND DEVICES EMPLOYING THERMOPLASTICS FROM THE POLYARYLETHERKETONE (PAEK) FAMILY OF SEMI-CRYSTALLINE THERMOPLASTICS FOR CALIBRATION AND/OR MONITORING OF OPTICAL MEASUREMENT DEVICES 审中-公开
    从半导体热电偶的聚醚醚酮（PAEK）家族中获取热塑性物质的方法和装置，用于校准和/或监测光学测量装置

    公开(公告)号：US20160363532A1

    公开(公告)日：2016-12-15

    申请号：US15176861

    申请日：2016-06-08

    Applicant: Gen-Probe Incorporated

    Inventor： Norbert D. HAGEN ,  David OPALSKY ,  George T. WALKER ,  Byron J. KNIGHT

    IPC: G01N21/64

    CPC classification number: G01N21/64 ,  G01N21/276 ,  G01N21/645

    Abstract: Optical reference devices for calibrating or monitoring the performance of an optical measurement device, such as a fluorometer, are made from thermoplastics from the polyaryletherketone (PAEK) family of semi-crystalline thermoplastics, including polyether ether ketone (PEEK). The reference device may be made as a master reference device having a known emission output—as determined by a standard optical measurement device—that is used to calibrate other optical measurement devices against the standard. The reference device may be made in the shape of a receptacle vial so that the reference device can be placed in the receptacle holding structure of an instrument in which the optical measurement device is installed and used to calibrate or monitor the optical measurement device within the instrument. The reference device may be part of the probe of a pipettor or pick and place mechanism or it may be a cap that can be secured to the end of such a probe.

    Abstract translation: 用于校准或监测诸如荧光计的光学测量装置的性能的光学参考装置由来自聚芳醚酮（PAEK）半结晶热塑性塑料系列（包括聚醚醚酮（PEEK））的热塑性塑料制成。 参考装置可以制成具有由标准光学测量装置确定的已知发射输出的主参考装置，该标准光学测量装置用于相对于标准校准其它光学测量装置。 参考装置可以制成容器小瓶的形状，使得参考装置可以放置在其中安装光学测量装置的仪器的容器保持结构中，并用于校准或监测仪器内的光学测量装置 。 参考装置可以是移液器或拾取和放置机构的探头的一部分，或者其可以是可固定到这种探针的端部的盖。

    METHOD FOR READING MACHINE-READABLE LABELS
    9.
    发明申请
    METHOD FOR READING MACHINE-READABLE LABELS 有权
    读取机器可读标签的方法

    公开(公告)号：US20140209677A1

    公开(公告)日：2014-07-31

    申请号：US14229676

    申请日：2014-03-28

    Applicant: STRATEC Biomedical AG ,  GEN-PROBE INCORPORATED

    Inventor： Craig B. CLARK ,  John M. GILKER ,  Norbert D. HAGEN ,  Olaf HÖRGER ,  Tom R. HORN ,  Byron J. KNIGHT ,  Waldemar LUKHAUB ,  David OPALSKY ,  Jason F. RHUBOTTOM

    IPC: G06Q10/08

    CPC classification number: G06Q10/087 ,  B01L9/06 ,  B01L2200/023 ,  B01L2200/06 ,  B01L2200/141 ,  B01L2300/021 ,  G01N35/1004

    Abstract: A structure for holding sample-containing receptacles includes a cover with holes formed therein through which the receptacles can be accessed with a substance transfer mechanism, such as a robotic pipettor. When the transfer mechanism is inserted into and then withdrawn from a receptacle, a string of viscous material may be suspended from the mechanism. A viscous string removal element adjacent each opening engages the string of viscous material and dislodges the string from the mechanism when the mechanism moves in a prescribed path with respect to the removal element. A sample rack configured to hold receptacles and to be inserted into the structure below the cover includes a sample rack having receptacle-receiving pockets, each with a resilient element and a positioning feature for holding receptacles of varying sizes in a predetermined position within the receptacle receiving pocket, and a cover including features for preventing a receptacle from being pulled out of its receptacle-receiving pocket when the transfer mechanism is withdrawn from the receptacle.

    Abstract translation: 用于保持含有样品的容器的结构包括其中形成有孔的盖，通过该盖可以用诸如机器人移液器的物质转移机构接近容器。 当转移机构插入到容器中然后从容器中取出时，一串粘性材料可以悬挂在机构上。 邻近每个开口的粘性排除元件与该粘性材料串接合，并且当机构相对于移除元件以规定的路径移动时，将该绳从机构中移出。 被配置成保持插座并插入到盖子下面的结构中的样品架包括具有插座容纳凹部的样品架，每个具有弹性元件和用于在插座接收中的预定位置保持不同尺寸的容器的定位特征 口袋和盖子，其包括当传送机构从容器中取出时防止插座从其容器接收口袋中被拉出的特征。

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