公开(公告)号：US20250154575A1

公开(公告)日：2025-05-15

申请号：US19022701

申请日：2025-01-15

Applicant: Gen-Probe Incorporated

Inventor： Jennifer L. TIDD ,  Anne-Laure SHAPIRO ,  Ankur H. SHAH ,  James T. TUGGLE ,  David OPALSKY ,  Alberto A. LIO ,  Timothy J. SCHEER ,  Jason F. RHUBOTTOM ,  David Aaron BUSE

IPC: C12Q1/6844

Abstract: Analyzing samples using an automated analyzer comprises retaining a first container containing a first solvent lacking an amplification oligomer at a first location of the analyzer, retaining a second container having a different structure than the first container and supporting solvent-containing vials at a second location of the analyzer, the solvent in each vial including an amplification oligomer, combining a first non-liquid reagent including at least one amplification oligomer with the first solvent and a first sample to form a first reaction mixture, combining a second non-liquid reagent lacking an amplification oligomer with the solvent included in a vial of the second container and a second sample to form a second reaction mixture, performing first and second amplification reactions with the first and second reaction mixtures, and determining the presence or absence of one or more analytes in the first and second reaction mixtures.

公开(公告)号：US20240393358A1

公开(公告)日：2024-11-28

申请号：US18797273

申请日：2024-08-07

Applicant: Gen-Probe Incorporated

Inventor： David A. BUSE ,  Norbert D. HAGEN ,  David OPALSKY

IPC: G01N35/04 ,  B65G29/00 ,  B65G47/84 ,  G01F23/263

Abstract: A mechanism for holding and moving a plurality of containers includes a carousel configured to be rotatable about a vertically-oriented axis of rotation, and the carousel includes a plurality of container-holding pockets arranged circumferentially around an outer periphery of the carousel. Each container includes a vertically-oriented groove formed on each of opposed sides of the container. Each container-holding pocket is open at the outer periphery of the carousel to permit a container to be withdrawn out of the pocket in a radial direction with respect to the axis of rotation, and each container-holding pocket includes retention clips configured to engage the grooves formed on the container to removably retain the container within the container pocket.

公开(公告)号：US20240150823A1

公开(公告)日：2024-05-09

申请号：US18544053

申请日：2023-12-18

Applicant: Gen-Probe Incorporated

Inventor： David BUSE ,  David Howard COMBS ,  Norbert D. HAGEN ,  David OPALSKY ,  Bruce RICHARDSON ,  Anita PRASAD ,  Keith MORAVICK ,  Tyler MOORE ,  Byron J. Knight

IPC: C12Q1/686 ,  B01L7/00 ,  G01N21/64

CPC classification number: C12Q1/686 ,  B01L7/52 ,  G01N21/6452 ,  B01L9/06 ,  B01L2200/142 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/1822 ,  G01N2021/6484

Abstract: An apparatus for incubating a plurality of receptacles includes one or more thermally-conductive receptacle holders, each comprising a plurality of receptacle wells. A thermally-conductive support is associated with each of the receptacle holders, and a thermal element is positioned between the associated support and the receptacle holder. A heat sink is in thermal communication with the support and comprises a plurality of spaced-apart fins. An optical fiber associated with each receptacle well has a first end positioned adjacent to or within a through-hole formed in the receptacle well and extends through through-holes formed in the support and the heat sink aligned with the through-hole of the receptacle well. Each of the optical fibers is positioned between two adjacent fins of the plurality of fins.

公开(公告)号：US20240043916A1

公开(公告)日：2024-02-08

申请号：US18361786

申请日：2023-07-28

Applicant: GEN-PROBE INCORPORATED

Inventor： Jennifer L. TIDD ,  Ann-Laure SHAPIRO ,  Ankur H. SHAH ,  James T. TUGGLE ,  David OPALSKY ,  Alberto A. LIO ,  Timothy J. SCHEER ,  Jason F. RHUBOTTOM ,  David Aaron BUSE

IPC: C12Q1/6844

CPC classification number: C12Q1/6844 ,  C12Q2523/32 ,  C12Q2527/101 ,  C12Q2531/113 ,  C12Q2565/629

Abstract: A method of performing a lab developed test for detecting a nucleic acid analyte on an automated analyzer. The method includes a first step of using a computer to select, define or modify one or more user-defined parameters of a protocol for performing the lab developed test on the analyzer, where each user-defined parameter of the protocol defines a step to be performed by the analyzer during the lab developed test. The method further includes a second step of performing the lab developed test with the protocol of the first step, where the analyzer stores one or more system-defined parameters for performing the lab developed test, the one or more system-defined parameters being installed on the analyzer prior to performing first step.

公开(公告)号：US20200282403A1

公开(公告)日：2020-09-10

申请号：US16811772

申请日：2020-03-06

Applicant: Gen-Probe Incorporated

Inventor： David H. COMBS ,  David A. BUSE ,  Norbert D. HAGEN ,  David OPALSKY ,  Jin CHEN

IPC: B01L9/00 ,  B66F9/07

Abstract: A system and method provides a supply of consumables to a processing instrument that uses one or more of the consumables for each of a plurality of processes performed by the instrument. The system includes a loading drawer holding a carrier for receiving a plurality of consumables and an input module for holding a carrier supporting a plurality of consumables thereon and presenting the consumables for access by the instrument. A transporter includes a vertical elevator and a lateral actuator for moving a lift platform vertically and laterally and for transporting carriers on the lift platform with or without consumables supported thereon between the loading drawer and the input module, between the loading drawer and one or more holding shelves, or between the input module and one or more holding shelves. A carrier includes parallel support rails for holding multiple receptacle units and retainer tabs for retaining the units on the support rails.

公开(公告)号：US20200271568A1

公开(公告)日：2020-08-27

申请号：US15930131

申请日：2020-05-12

Applicant: GEN-PROBE INCORPORATED

Inventor： Norbert D. HAGEN ,  Byron KNIGHT ,  David OPALSKY

IPC: G01N21/15 ,  B08B1/00 ,  B08B9/00 ,  G01N35/00 ,  G02B6/38

Abstract: A cleaning member including a distal cleaning element and a proximal coupling element, where the coupling element has a proximal end portion dimensioned to form a frictional fit with a working end of an automated transport arm.

公开(公告)号：US20190026516A1

公开(公告)日：2019-01-24

申请号：US16052448

申请日：2018-08-01

Applicant: GEN-PROBE INCORPORATED

Inventor： David OPALSKY

IPC: G06K7/10 ,  B01L3/00 ,  B01L9/06 ,  G01N35/00 ,  G06K19/06 ,  G06K7/14

Abstract: A method of reading machine-readable marks on a movable support and object of a sample instrument. The method includes capturing a first image of the moveable support as the moveable support moves from a first position to a second position using an image capture device; determining whether a first fiducial machine-readable mark on the moveable support is in the first image; determining, when the first fiducial machine-readable mark is in the first image, whether a first machine-readable mark on a first object coupled to the moveable support is in the first image at a predetermined position relative to the first fiducial machine-readable mark; and associating information decoded from the first machine-readable mark on the first object with a first location on the moveable support associated with the first fiducial machine-readable mark.

公开(公告)号：US20170191933A1

公开(公告)日：2017-07-06

申请号：US15389897

申请日：2016-12-23

Applicant: Gen-Probe Incorporated

Inventor： David OPALSKY ,  Srajan RAGHUWANSHI ,  James BUI

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N21/0332 ,  G01N21/276 ,  G01N21/75 ,  G01N35/00732 ,  G01N35/025 ,  G01N2021/6441 ,  G01N2035/00356 ,  G01N2035/0455 ,  G01N2035/0475 ,  G01N2035/0484 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/12723

Abstract: A system for measuring optical signal detector performance includes an optical signal detector comprising a first detection channel having a first light source and a first sensor. The first detection channel is configured to emit and focus light generated by the first light source at a first detection zone, and to receive and focus light on the first sensor. The system also includes a controller operatively coupled to the optical signal detector and configured to determine an operational performance status of the optical signal detector based on at least one of (i) a first measured characteristic of light focused on the sensor while a first non-fluorescent surface portion is in the first detection zone and (ii) a second measured characteristic of light focused on the sensor while a void is in the first detection zone. The optical signal detector can be a fluorometer.

公开(公告)号：US20150196915A1

公开(公告)日：2015-07-16

申请号：US14669419

申请日：2015-03-26

Applicant: GEN-PROBE INCORPORATED

Inventor： Norbert D. HAGEN ,  Byron J. KNIGHT ,  David OPALSKY

IPC: B01L3/00 ,  B01L9/00

CPC classification number: B01L3/52 ,  B01L3/561 ,  B01L9/52 ,  B01L2300/0609 ,  B01L2300/12 ,  B03C1/0332 ,  B03C1/12 ,  B03C1/14 ,  B03C1/28 ,  B03C1/286 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  B25J11/00 ,  B65B3/04 ,  C12N15/1013 ,  G01N35/0098 ,  Y10T29/49815

Abstract: Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a proton of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.

公开(公告)号：US20140263984A1

公开(公告)日：2014-09-18

申请号：US14200460

申请日：2014-03-07

Applicant: GEN-PROBE INCORPORATED

Inventor： Norbert D. HAGEN ,  David OPALSKY

IPC: G01N21/64 ,  G02B6/08 ,  G01J1/02 ,  G02B6/06 ,  G01J1/42 ,  G01J1/04

CPC classification number: G02B6/3668 ,  G01N21/253 ,  G01N21/6452 ,  G01N2021/6484 ,  G02B6/06 ,  G02B6/08 ,  G02B6/3672 ,  G02B6/4214 ,  G02B6/4246 ,  G02B6/4269

Abstract: An indexing signal detection module is configured to index one or more signal detectors past each of a plurality of sources of detectable signal emissions to detect or measure a signal emitted by each source. A plurality of signal transmission conduits transmit signal emitted by the sources from a first end of each conduit to a second end of each conduit where the signal may be detected by a signal detector. A conduit reformatter is configured to secure the first ends of the respective signal transmission conduits in a first spatial arrangement corresponding to a spatial arrangement of the signal emission sources and to secure the second ends of the respective signal transmission conduits in a second spatial arrangement different from the first spatial arrangement.

Abstract translation: 索引信号检测模块被配置为将一个或多个信号检测器转移到多个可检测信号发射源中的每一个上，以检测或测量由每个源发射的信号。 多个信号传输管道将源发射的信号从每个管道的第一端传送到每个管道的第二端，其中信号可由信号检测器检测。 导管重新配置器被配置为以对应于信号发射源的空间布置的第一空间布置来固定各个信号传输导管的第一端，并且将相应的信号传输导管的第二端固定在不同于 第一个空间安排。