公开(公告)号：US10744203B2

公开(公告)日：2020-08-18

申请号：US16264364

申请日：2019-01-31

Applicant: Purdue Research Foundation ,  University of Utah Research Foundation

Inventor： Stewart Andrew Low ,  Philip S. Low ,  Christopher Galliford ,  Jindrich Kopecek ,  Jiyan Yang

IPC: A61K31/404 ,  C07D403/04 ,  C07D209/34 ,  C07D487/00 ,  A61K47/42 ,  A61L27/22 ,  A61L27/54 ,  C07K7/06 ,  C07K7/08 ,  A61P19/00 ,  A61K9/107 ,  A61M5/00

Abstract: Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3β, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

公开(公告)号：US10517957B2

公开(公告)日：2019-12-31

申请号：US15997451

申请日：2018-06-04

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  A61K47/54 ,  A61K51/04 ,  C07K5/08 ,  C07C323/52 ,  C07D207/416 ,  A61K49/00 ,  A61K31/426 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US10517956B2

公开(公告)日：2019-12-31

申请号：US15990083

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  A61K47/54 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/04 ,  A61K51/08 ,  C07K5/08 ,  C07C323/52 ,  C07D207/416 ,  A61K49/00 ,  A61K31/426

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US10406240B2

公开(公告)日：2019-09-10

申请号：US15606913

申请日：2017-05-26

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K47/64 ,  A61K47/54 ,  A61K51/04 ,  C07C323/52 ,  C07K5/08 ,  C07D207/416 ,  A61K49/00 ,  A61K31/426 ,  A61K31/4745 ,  A61K31/475 ,  A61K51/08

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

公开(公告)号：US09333270B2

公开(公告)日：2016-05-10

申请号：US14010098

申请日：2013-08-26

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00 ,  G01N33/569 ,  G01N33/566 ,  G01N33/50 ,  G01N33/58 ,  G01N33/68

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

公开(公告)号：US09180215B2

公开(公告)日：2015-11-10

申请号：US14058567

申请日：2013-10-21

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  A61K51/08 ,  A61K51/04 ,  C07B59/00 ,  C07D475/04

CPC classification number: A61K51/088 ,  A61K51/0497 ,  C07B59/002 ,  C07D475/04

Abstract: Described herein are compositions and methods for diagnosing and/or monitoring pathogenic disease states using positron emission tomography, wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. Also described herein are 18F conjugates of vitamins and vitamin receptor-binding analogs and derivatives.

Abstract translation: 本文描述了使用正电子发射断层扫描来诊断和/或监测致病性疾病状态的组合物和方法，其中致病细胞独特地表达，优先表达或过量表达维生素受体。 本文还描述了维生素和维生素受体结合类似物和衍生物的18F缀合物。

公开(公告)号：US20150110798A1

公开(公告)日：2015-04-23

申请号：US14524304

申请日：2014-10-27

Applicant: Purdue Research Foundation ,  The United States of America, as Represented by the Secretary Department of Health and Human Servi

Inventor： Philip S. Low ,  Dimiter S. Dimitrov ,  Yang Feng ,  Jiayin Shen

IPC: C07K16/28

CPC classification number: C07K16/28 ,  A61K9/0019 ,  A61K9/127 ,  A61K38/00 ,  A61K47/6849 ,  A61K47/6911 ,  A61K47/6913 ,  A61K49/0058 ,  A61K49/16 ,  A61K51/1027 ,  C07K14/705 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/54 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92

Abstract: Human anti-human folate receptor beta antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments to treat inflammatory disorders or cancers expressing cell surface FRβ.

Abstract translation: 本发明描述了人类抗人叶酸受体β抗体及其抗原结合片段，以及使用此类抗体和片段来治疗表达细胞表面FR＆bgr的炎性疾病或癌症的方法。

公开(公告)号：US20150050212A1

公开(公告)日：2015-02-19

申请号：US14380273

申请日：2013-02-22

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Charity Wayua

IPC: A61K47/48 ,  A61K38/08 ,  A61K51/02 ,  A61K38/07 ,  A61K38/06 ,  A61K49/00

CPC classification number: A61K47/48061 ,  A61K31/4409 ,  A61K31/475 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K47/545 ,  A61K49/0052 ,  A61K51/02 ,  A61K51/0468 ,  A61K51/047 ,  C07D243/12 ,  C07D405/12

Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.

Abstract translation: 本文描述了缀合物，其中CCK2R靶向配体通过接头连接到活性部分，例如治疗剂或成像剂。 该结合物可用于癌症的检测，诊断，成像和治疗。

公开(公告)号：US20140112866A1

公开(公告)日：2014-04-24

申请号：US14058567

申请日：2013-10-21

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K51/08

CPC classification number: A61K51/088 ,  A61K51/0497 ,  C07B59/002 ,  C07D475/04

Abstract: Described herein are compositions and methods for diagnosing and/or monitoring pathogenic disease states using positron emission tomography, wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. Also described herein are 18F conjugates of vitamins and vitamin receptor-binding analogs and derivatives.

Abstract translation: 本文描述了使用正电子发射断层扫描来诊断和/或监测致病性疾病状态的组合物和方法，其中致病细胞独特地表达，优先表达或过量表达维生素受体。 本文还描述了维生素和维生素受体结合类似物和衍生物的18F缀合物。

公开(公告)号：US20140057289A1

公开(公告)日：2014-02-27

申请号：US14037476

申请日：2013-09-26

Applicant: Purdue Research Foundation

Inventor： Cagri A. Savran ,  Philip S. Low ,  Chun-Li Chang ,  Wanfeng Huang

IPC: G01N27/74

CPC classification number: B01L3/502761 ,  B01L3/50273 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0877 ,  B01L2400/043 ,  G01N27/745 ,  G01N33/54326 ,  G01N33/574 ,  G01N33/57434 ,  G01N33/57492 ,  G01N2001/4016

Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target entities bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target entities from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target entities bound to magnetic beads on the surface of the plate. In a further feature, the microfluidic detection system is configured to pass target molecules through the plate to be bound to a functionalized surface of the lower chamber.

Abstract translation: 用于微米尺寸实体（例如生物细胞）的微流体检测系统包括结合有多个开口的板的检测器部件，该板分离两个室，一个与包含与磁珠结合的目标实体的流体源连通。 这些开口的尺寸设置成总是允许磁珠通过其进入下部的一个室，并且进一步的尺寸以防止目标实体从上部的一个室中通过。 检测器部件还包括磁铁，该磁体定位成将未结合的磁珠拉过开口并且捕获与板的表面上的磁珠接合的目标实体。 在另一个特征中，微流体检测系统被配置成使目标分子穿过板结合到下腔室的官能化表面。