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公开(公告)号：US11848531B2
公开(公告)日：2023-12-19
申请号：US17696755
申请日：2022-03-16
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife , Benjamin Cipriany
IPC: H01S3/0941 , H01S3/00 , H01S3/1115 , H01S3/02 , H01S3/081 , G02F1/37 , H01S3/08 , H01S3/16 , H01S3/10 , H01S3/1112 , H01S3/04 , H01S3/06 , H01S3/042
CPC classification number: H01S3/1115 , G02F1/37 , H01S3/025 , H01S3/0813 , H01S3/08072 , H01S3/09415 , H01S3/1611 , H01S3/1673 , H01S3/0092 , H01S3/042 , H01S3/0407 , H01S3/0623 , H01S3/0811 , H01S3/0941 , H01S3/10046 , H01S3/1112 , H01S3/1653
Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.
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公开(公告)号：US11322906B2
公开(公告)日：2022-05-03
申请号：US16916277
申请日：2020-06-30
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife , Benjamin Cipriany
IPC: H01S3/11 , G02F1/37 , H01S3/02 , H01S3/081 , H01S3/0941 , H01S3/08 , H01S3/16 , H01S3/10 , H01S3/04 , H01S3/06 , H01S3/00 , H01S3/042
Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.
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公开(公告)号：US20210379591A1
公开(公告)日：2021-12-09
申请号：US17236826
申请日：2021-04-21
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , John H. Leamon , Jonathan C. Schultz , Michele Millham , Caixia Lv , Haidong Huang , Roger Nani , Omer Ad , Brian Reed , Matthew Dyer , Robert E. Boer
IPC: B01L3/00 , C12Q1/6806
Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).
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公开(公告)号：US20210331170A1
公开(公告)日：2021-10-28
申请号：US17236889
申请日：2021-04-21
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , John H. Leamon , Jonathan C. Schultz , Michele Millham , Caixia Lv , Haidong Huang , Roger Nani , Omer Ad , Brian Reed , Matthew Dyer , Robert E. Boer
IPC: B01L3/00 , C12Q1/6806 , G01N33/68
Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).
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公开(公告)号：US20210277463A1
公开(公告)日：2021-09-09
申请号：US17314968
申请日：2021-05-07
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. File
IPC: C12Q1/6869 , G01N21/64 , H01L27/146 , H01S3/101 , H01S3/13 , H01S3/105 , H01S3/081 , H01S3/11 , H01S3/0941 , H01S3/10 , H01S3/00
Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.
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Patent Agency Ranking
公开(公告)号：US11072827B2
公开(公告)日：2021-07-27
申请号：US16239789
申请日：2019-01-04
Applicant: Quantum-Si Incorporated
Inventor： Guojun Chen , Jeremy Lackey , Alexander Goryaynov , Gerard Schmid , Ali Kabiri , Jonathan M. Rothberg , Todd Rearick , Jonathan C. Schultz , Farshid Ghasemi , Keith G. Fife
IPC: C12Q1/6869 , G01N21/64 , B01L3/00 , G01N30/86 , C08L1/02 , C12Q1/6806 , G01N27/447 , G01N30/88
Abstract: Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.
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公开(公告)号：US20210121879A1
公开(公告)日：2021-04-29
申请号：US17082223
申请日：2020-10-28
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , John H. Leamon , Jonathan C. Schultz , Michele Millham , Caixia Lv , Xiaxiao Ma
Abstract: Methods and devices for isolating or enriching target molecules from a sample are provided herein. In some embodiments, methods and devices further involve detection, analysis and/or sequencing of a target molecule.
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公开(公告)号：US20200158640A1
公开(公告)日：2020-05-21
申请号：US16751135
申请日：2020-01-23
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Brendan Huang , Paul E. Glenn , Jonathan C. Schultz , Jose Camara
Abstract: Compact optical sources and methods for producing short and ultrashort optical pulses are described. A semiconductor laser or LED may be driven with a bipolar waveform to generate optical pulses with FWHM durations as short as approximately 85 ps having suppressed tail emission. The pulsed optical sources may be used for fluorescent lifetime analysis of biological samples and time-of-flight imaging, among other applications.
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公开(公告)号：US10246742B2
公开(公告)日：2019-04-02
申请号：US15161088
申请日：2016-05-20
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife
IPC: G01N21/25 , C12Q1/6869 , H01S3/11 , H01S3/00 , H01S3/101 , H01S3/13 , H01S3/10 , H01S3/0941 , G01N21/64 , H01L27/146 , H01S3/081 , H01S3/105 , H01S3/04 , H01S3/16 , G01S7/481
Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.
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公开(公告)号：US20160344156A1
公开(公告)日：2016-11-24
申请号：US15161088
申请日：2016-05-20
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife
CPC classification number: C12Q1/6869 , G01N21/6408 , G01N21/645 , G01N21/6458 , G01N2021/6439 , G01N2021/6441 , G01S7/4814 , H01L27/14603 , H01S3/0071 , H01S3/0405 , H01S3/0817 , H01S3/0941 , H01S3/10061 , H01S3/101 , H01S3/105 , H01S3/1115 , H01S3/1118 , H01S3/1305 , H01S3/1611 , H01S3/1673
Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.
Abstract translation: 描述了用于产生超短光脉冲的装置和方法。 大功率，固态，被动锁模激光器可以在紧凑的模块中制造，可以并入到用于生物或化学分析的便携式仪器中。 脉冲激光器可以以与电子数据采集速率相称的重复速率产生次100ps光脉冲。 光脉冲可以在仪器的反应室中激发样品，并用于产生用于操作仪器的信号采集和信号处理电子设备的参考时钟。
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