公开(公告)号：US20210354134A1

公开(公告)日：2021-11-18

申请号：US17236858

申请日：2021-04-21

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  John H. Leamon ,  Jonathan C. Schultz ,  Michele Millham ,  Caixia Lv ,  Haidong Huang ,  Roger Nani ,  Omer Ad ,  Brian Reed ,  Matthew Dyer ,  Robert E. Boer

IPC: B01L3/00 ,  C12Q1/6806

Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).

公开(公告)号：US20210354133A1

公开(公告)日：2021-11-18

申请号：US17236804

申请日：2021-04-21

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  John H. Leamon ,  Jonathan C. Schultz ,  Michele Millham ,  Caixia Lv ,  Haidong Huang ,  Roger Nani ,  Omer Ad ,  Brian Reed ,  Matthew Dyer ,  Robert E. Boer

IPC: B01L3/00 ,  C12Q1/6806

Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).

公开(公告)号：US20210148922A1

公开(公告)日：2021-05-20

申请号：US17082940

申请日：2020-10-28

Applicant: Quantum-Si Incorporated

Inventor： Matthew Dyer ,  Brian Reed

IPC: G01N33/68

Abstract: Provided herein are methods of single-polypeptide sequencing and reconstruction. Also provided herein are compositions, kits and devices useful for the same.

公开(公告)号：US20210139973A1

公开(公告)日：2021-05-13

申请号：US17082918

申请日：2020-10-28

Applicant: Quantum-Si Incorporated

Inventor： Matthew Dyer ,  Brian Reed

IPC: C12Q1/6869

Abstract: Provided herein are methods of single-cell polypeptide and/or polynucleic acid sequencing, which facilitate the direct sequencing of a single cell without amplification. Also provided herein are compositions, kits and devices useful for the same.

公开(公告)号：US20240344122A1

公开(公告)日：2024-10-17

申请号：US18599113

申请日：2024-03-07

Applicant: Quantum-Si Incorporated

Inventor： Matthew Dyer ,  Brian Reed

IPC: C12Q1/6869

CPC classification number: C12Q1/6869 ,  C12Q2563/185

Abstract: Provided herein are methods of single-cell polypeptide and/or polynucleic acid sequencing, which facilitate the direct sequencing of a single cell without amplification. Also provided herein are compositions, kits and devices useful for the same.

公开(公告)号：US20230192761A1

公开(公告)日：2023-06-22

申请号：US17837360

申请日：2022-06-10

Applicant: Quantum-Si Incorporated

Inventor： Haidong Huang ,  Roger Nani ,  Omer Ad ,  Brian Reed ,  Matthew Dyer ,  Robert E. Boer

IPC: C07K1/12 ,  C07K14/195

CPC classification number: C07K1/128 ,  C07K14/195

Abstract: The present disclosure relates to compounds and methods for selective C-terminal functionalization of peptides. In certain embodiments, the compounds have improved water-solubility, and are suitable for use in connection with peptide sequencing methodologies.

公开(公告)号：US20210379591A1

公开(公告)日：2021-12-09

申请号：US17236826

申请日：2021-04-21

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  John H. Leamon ,  Jonathan C. Schultz ,  Michele Millham ,  Caixia Lv ,  Haidong Huang ,  Roger Nani ,  Omer Ad ,  Brian Reed ,  Matthew Dyer ,  Robert E. Boer

IPC: B01L3/00 ,  C12Q1/6806

Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).

公开(公告)号：US20210331170A1

公开(公告)日：2021-10-28

申请号：US17236889

申请日：2021-04-21

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  John H. Leamon ,  Jonathan C. Schultz ,  Michele Millham ,  Caixia Lv ,  Haidong Huang ,  Roger Nani ,  Omer Ad ,  Brian Reed ,  Matthew Dyer ,  Robert E. Boer

IPC: B01L3/00 ,  C12Q1/6806 ,  G01N33/68

Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).

公开(公告)号：US20210221839A1

公开(公告)日：2021-07-22

申请号：US17153490

申请日：2021-01-20

Applicant: Quantum-Si Incorporated

Inventor： Haidong Huang ,  Roger Nani ,  Omer Ad ,  Brian Reed ,  Matthew Dyer ,  Robert E. Boer

IPC: C07K1/12 ,  C07K14/195

Abstract: The present disclosure relates to compounds and methods for selective C-terminal functionalization of peptides. In certain embodiments, the compounds have improved water-solubility, and are suitable for use in connection with peptide sequencing methodologies.

公开(公告)号：US20210148921A1

公开(公告)日：2021-05-20

申请号：US17082899

申请日：2020-10-28

Applicant: Quantum-Si Incorporated

Inventor： Brian Reed ,  Matthew Dyer

IPC: G01N33/68 ,  G01N33/543

Abstract: Aspects of the application provide methods of preparing an enriched sample for polypeptide sequencing, and compositions, kits and devices useful for the same.