公开(公告)号：US20200045957A1

公开(公告)日：2020-02-13

申请号：US16658457

申请日：2019-10-21

Applicant: University of Southern California

Inventor： Danhong Zhu ,  David R. Hinton ,  Ashish Ahuja ,  Mark S. Humayun

IPC: A01N1/02 ,  C12N5/079 ,  A61L27/58 ,  A61L27/38 ,  A61L27/34 ,  A61L27/16

Abstract: Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.

公开(公告)号：US10406227B2

公开(公告)日：2019-09-10

申请号：US14650208

申请日：2013-12-18

Applicant: University of Southern California ,  California Institute of Technology

Inventor： Robert H. Chow ,  Mark S. Humayun ,  Harry B. Gray ,  Robert H. Grubbs ,  Dennis A. Dougherty ,  Mark E. Thompson ,  Lionel E. Cheruzel ,  Melanie A. Yen

IPC: A61K41/00 ,  C12N13/00 ,  A61N5/06 ,  A61B3/113

Abstract: Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.

公开(公告)号：US20190151499A1

公开(公告)日：2019-05-23

申请号：US16222918

申请日：2018-12-17

Applicant: University of Southern California ,  California Institute of Technology ,  The Regents of the University of California

Inventor： Mark S. Humayun ,  Ashish Ahuja ,  Yu-Chong Tai ,  David R. Hinton ,  Robert H. Grubbs ,  Dennis O. Clegg ,  Lincoln Vallance Johnson ,  Sherry T. Hikita

IPC: A61L27/18 ,  A61K47/34 ,  A61K35/30 ,  A61L27/38 ,  A61L27/56 ,  A61K35/545 ,  A61K9/00

Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

公开(公告)号：US10232043B2

公开(公告)日：2019-03-19

申请号：US15240997

申请日：2016-08-18

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Melanie A. Yen ,  Dennis A. Dougherty ,  Robert H. Grubbs ,  Harry B. Gray ,  Robert H. Chow ,  Mark S. Humayun ,  Mark E. Thompson ,  Lionel E. Cheruzel

IPC: C12N13/00 ,  A61K41/00 ,  A61N5/06 ,  A61F9/007

Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.

公开(公告)号：US09655774B2

公开(公告)日：2017-05-23

申请号：US14744439

申请日：2015-06-19

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Yu-Chong Tai ,  Nicholas Scianmarello ,  Dongyang Kang ,  Jungwook Park ,  Mark S. Humayun ,  Karthik Murali ,  Amir H. Kashani ,  Hossein Nazari Khanamiri

IPC: A61M5/00 ,  A61F9/00 ,  B29C39/10 ,  B29C65/00 ,  B29C65/02 ,  B29K83/00 ,  B29C41/36 ,  B29L31/00

CPC classification number: A61F9/0017 ,  A61F2240/001 ,  A61F2250/0068 ,  B29C39/10 ,  B29C41/36 ,  B29C65/02 ,  B29C66/1142 ,  B29C66/3242 ,  B29C66/54 ,  B29C66/71 ,  B29C66/73754 ,  B29C66/919 ,  B29C66/949 ,  B29K2083/005 ,  B29L2031/7548

Abstract: A medical device having a permeable bag connected by a non-permeable cannula to a discharge sac is described along with a manufacturing process and surgical implantation method. The permeable portions of the device have pores that are sized to be permeable to a predetermined class of small molecules, such as oxygen, nitrous oxide, or other therapeutic agents. Once absorbed inside the device, the small molecules are then passively transported, by a concentration gradient of the small molecules, to the discharge sac to be disbursed. A metal tube or other strip can be included in the cannula to assist a surgeon in orienting the device within the body.

公开(公告)号：US20160271290A1

公开(公告)日：2016-09-22

申请号：US15074909

申请日：2016-03-18

Applicant: University of Southern California

Inventor： Mark S. Humayun ,  Aldo Oregon ,  Yi Zhang

IPC: A61L15/24 ,  A61F9/007 ,  A61L15/64 ,  A61L15/58 ,  A61L15/44

CPC classification number: A61F9/00727 ,  A61L27/18 ,  A61L27/222 ,  A61L27/225 ,  A61L27/227 ,  A61L27/24 ,  A61L2430/16 ,  C08L65/04

Abstract: Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.

Abstract translation: 本文公开的若干实施方案涉及用于治疗或修复对眼组织损伤的组合物和方法。 特别地，几个实施例涉及例如通过粘合剂与损伤的视网膜组织相互作用以修复或修补视网膜的眼睛，从眼底组织撕裂或脱离的贴片。 另外的实施例涉及自组装补丁。

公开(公告)号：US20130289497A1

公开(公告)日：2013-10-31

申请号：US13931074

申请日：2013-06-28

Applicant: University of Southern California

Inventor： Mark S. Humayun ,  Sean Caffey

IPC: A61F9/00

CPC classification number: A61F9/0017 ,  A61F9/0026 ,  A61F2250/0068 ,  A61M31/002

Abstract: In various embodiments, a drug-delivery device includes one or more reservoirs that may each contain a therapeutic agent for delivery to a patient.

公开(公告)号：US12025858B2

公开(公告)日：2024-07-02

申请号：US17013759

申请日：2020-09-07

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Charles M. T. DeBoer ,  Mark S. Humayun

IPC: G02C7/04 ,  G02C7/08 ,  A61K9/00

CPC classification number: G02C7/049 ,  G02C7/04 ,  G02C7/041 ,  G02C7/085 ,  A61K9/0051

Abstract: A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.

公开(公告)号：US12004996B2

公开(公告)日：2024-06-11

申请号：US17984046

申请日：2022-11-09

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Yu-Chong Tai ,  Aubrey M. Shapero ,  Nicholas E. Scianmarello ,  Mark S. Humayun

IPC: A61F9/00 ,  A61K9/00 ,  A61M31/00 ,  G02C7/04

CPC classification number: A61F9/0017 ,  A61K9/0051 ,  A61M31/002 ,  A61F2250/0068 ,  B01L2400/082 ,  G02C7/049

Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.

公开(公告)号：US20230355973A1

公开(公告)日：2023-11-09

申请号：US18026443

申请日：2021-09-24

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Mark S. Humayun ,  Lan Yue

IPC: A61N1/36 ,  A61N1/372 ,  A61N1/05 ,  A61F9/08

CPC classification number: A61N1/36046 ,  A61N1/37217 ,  A61N1/0543 ,  A61N1/36196 ,  A61F9/08

Abstract: A system and method are disclosed for causing or enhancing the perception of color in a blind or visually impaired person. The system may comprise: an electromagnetic stimulation device associated with the blind or visually impaired person; and a visualization device for receiving an image and detecting a color of an object in the image, wherein the electromagnetic stimulation device is configured to stimulate the blind or visually impaired person based on a parameter of electromagnetic stimulation that varies based on the color detected by the visualization device. The method may comprise: varying a parameter of electromagnetic stimulation of an electromagnetic stimulation device, associated with an eye of the blind or visually impaired person, based on which color is detected by a visualization device that is used in conjunction with the electromagnetic stimulation device; and stimulating the eye with the electromagnetic stimulation device according to the parameter of electromagnetic stimulation.