公开(公告)号：US06594010B2

公开(公告)日：2003-07-15

申请号：US09899875

申请日：2001-07-06

Applicant: Mark Leonard Malczewski ,  Joseph Wegrzyn ,  Wayne Donald Martin

Inventor： Mark Leonard Malczewski ,  Joseph Wegrzyn ,  Wayne Donald Martin

IPC: G01J330

CPC classification number: G01J3/2803 ,  G01J3/443

Abstract: An analyzer suitable for performing continuous gas analysis in ultra-high purity applications. The analyzer combines a low-level emission source and a gaseous emission spectrometer having a charge coupled device (CCD) diode array as a detector. The CCD detector replaces one or more photomultipliers and narrow bandpass filters typically used in spectrometers. The analyzer performs various processing operations to evaluate and eliminate the effect of background light level, or dark spectrum.

Abstract translation: 适用于在超高纯度应用中进行连续气体分析的分析仪。 分析仪结合了低电平发射源和具有电荷耦合器件（CCD）二极管阵列作为检测器的气体发射光谱仪。 CCD检测器代替通常用于光谱仪中的一个或多个光电倍增管和窄带通滤波器。 分析仪执行各种处理操作，以评估和消除背景光等级或暗光谱的影响。

公开(公告)号：US06538735B1

公开(公告)日：2003-03-25

申请号：US09512707

申请日：2000-02-25

Applicant: Juerg Duebendorfer ,  Donald Jones ,  Kenneth Neumann ,  Chang Jin Wang

Inventor： Juerg Duebendorfer ,  Donald Jones ,  Kenneth Neumann ,  Chang Jin Wang

IPC: G01J330

CPC classification number: G01N21/6452 ,  G01N21/6428 ,  G01N2201/0648

Abstract: An apparatus for measuring light in samples using a high intensity light source, is presented. The system utilizes bifurcated fiber bundles to transmit light at the excitation and emission wavelength bands. It also uses a band-pass filter for eliminating extraneous light, including that which corresponds to the excitation wavelength range, while permitting the emitted light to pass to a detector for quantitation. The system employs a shutter to shield the detector while the laser light source is activated, and a controller to intermittently activate the laser light and close the shutter. The apparatus preferably includes lenses for better illumination and read out conditions. The apparatus is employed in Luminescence Oxygen Channeling Immunoassays. The method has high sensitivity, accuracy and precision, and the apparatus is highly compact. Accordingly, the analyzer can perform assays in nanoliter to microliter sample volumes in standard microplates having at least 96, 384 or 1536 wells.

Abstract translation: 提出了一种使用高强度光源测量样品中的光的装置。 该系统利用分叉光纤束在激发和发射波长带发射光。 它还使用带通滤波器来消除外来光，包括对应于激发波长范围的光，同时允许发射的光通过检测器进行定量。 该系统在激活激光光源时使用快门屏蔽检测器，并且控制器间歇地激活激光并关闭快门。 该装置优选地包括用于更好照明和读出条件的透镜。 该装置用于发光氧通道免疫测定。 该方法灵敏度高，精度高，精度高，装置高度紧凑。 因此，分析仪可以在具有至少96个，384个或1536个孔的标准微孔板中进行纳升至微升样品体积的测定。

公开(公告)号：US06519030B1

公开(公告)日：2003-02-11

申请号：US09647178

申请日：2000-09-27

Applicant: Paul R Norman ,  George A Robins ,  Arthur M Johnston ,  Grant S Richardson

Inventor： Paul R Norman ,  George A Robins ,  Arthur M Johnston ,  Grant S Richardson

IPC: G01J330

CPC classification number: G01N21/72

Abstract: A flame photometer detector is described which uses flame emission spectroscopy as the detection method, computer control and data acquisition, pulsed sampling and a rotating reference filter wheel to eliminate the effects of background chemical species. The detector is particularly suited to the testing of respirator equipment.

Abstract translation: 描述了一种火焰光度计检测器，其使用火焰发射光谱仪作为检测方法，计算机控制和数据采集，脉冲采样和旋转参考滤光轮，以消除背景化学物质的影响。 检测器特别适用于呼吸器械的测试。

公开(公告)号：US06452179B1

公开(公告)日：2002-09-17

申请号：US09372968

申请日：1999-08-12

Applicant: John Coates ,  Neil Rosenbaum ,  Yosef Abuneaj

Inventor： John Coates ,  Neil Rosenbaum ,  Yosef Abuneaj

IPC: G01J330

CPC classification number: G01N33/30 ,  G01J3/28 ,  G01J3/443 ,  G01N21/274 ,  G01N21/3577 ,  G01N21/67 ,  G01N21/69 ,  G01N33/2847 ,  G01N33/2858 ,  G01N33/2888

Abstract: An apparatus (10) for analyzing lubricant oils and functional fluids includes an optical emission spectrometer (OES) (26) having a substantially continuously valued wavelength versus intensity output (140). The OES (26) analyzes light captured from a spark emission stand (58) through which the fluid sample is flowed. An expert system (160-172) operates according to a set of Rules that corrects background influence from the electrodes, and generates diagnostic text (174) for an operator based on the information about the fluid sample provided by the OES (26) and other measurement devices. The apparatus (10) is reduce in size, weight and cost.

Abstract translation: 用于分析润滑油和功能流体的装置（10）包括具有基本上连续值的波长对强度输出（140）的光发射光谱仪（OES）（26）。 OES（26）分析从流体样品流过的火花发射台（58）捕获的光。 专家系统（160-172）根据一组修正来自电极的背景影响的规则进行操作，并且基于由OES（26）等提供的流体样本的信息为操作者生成诊断文本（174） 测量装置。 装置（10）的尺寸，重量和成本都降低。

公开(公告)号：US06377344B2

公开(公告)日：2002-04-23

申请号：US09295554

申请日：1999-04-21

Applicant: Guenter Schoeppe

Inventor： Guenter Schoeppe

IPC: G01J330

CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/14 ,  G01J3/36 ,  G01J2003/1286 ,  G02B21/0064

Abstract: A device for the adjustable coupling of wavelengths or wavelength regions into the illumination beam path of a microscope, preferably in the beam path of a confocal microscope, comprising at least one dispersive element for wavelength separation of the illumination light and at least one at least partially reflecting element arranged in the wavelength-separated portion of the illumination light for reflecting back a wavelength region in the direction of the microscope illumination, and a device for the adjustable detection of object light coming from an illuminated object, preferably in a microscope beam path, comprising at least one dispersive element for wavelength separation of the object light and means arranged in the wavelength-separated portion of the object light for the adjustable stopping down or cutting out of at least one wavelength region and deflection in the direction of at least one detector.

Abstract translation: 用于将波长或波长区域可调节耦合到显微镜的照明光束路径中的装置，优选地在共焦显微镜的光束路径中，包括用于照明光的波长分离的至少一个色散元件和至少部分地至少部分地 布置在照明光的波长分离部分中的反射元件，用于反射显微照明方向上的波长区域;以及用于可调节地检测来自被照射物体的物体光，优选在显微镜光路中的装置， 包括用于对象光的波长分离的至少一个色散元件和布置在物体光的波长分离部分中的装置，用于可调节地停止或切除至少一个波长区域并沿着至少一个检测器的方向偏转 。

公开(公告)号：US06813017B1

公开(公告)日：2004-11-02

申请号：US09691155

申请日：2000-10-19

Applicant: Robert A. Hoffman ,  Eric S. Chase

Inventor： Robert A. Hoffman ,  Eric S. Chase

IPC: G01J330

CPC classification number: G01N15/147 ,  G01N15/1434 ,  G01N2015/1447 ,  G01N2015/1493

Abstract: An apparatus and method for examining particles in a flow stream of a flow cytometer, employing incoherent light sources, such as light emitting diodes (LEDs), and detectors. The light emitting diodes operate as the excitation light sources and emit light toward said flow stream, and the detectors detect light, in particular, fluorescent light, emanating from the particles in response to the excitation light striking the particles. A controller controls each of the light emitting diodes to emit their excitation light for a predetermined period during which the excitation light radiates onto particles of interest. The controller evaluates the detected light to ascertain characteristics of the particles, such as particle size, density and granularity. The apparatus and method can further employ one or more coherent and homogenous light emitting devices, such as a laser, as an additional excitation light source. The detectors can detect the LED-excited fluorescence or the laser-excited fluorescence from the particles, and the controller can evaluate both types of detected light to ascertain characteristics of the particles. Furthermore, the controller can control the LEDs to operate in a pulsed manner, which can be synchronized with the detection of the laser-excited fluorescence or light scatter. In addition, a substantially opaque panel having one or more slits can be positioned at the image plane upon which an image of the flow stream is projected, so that the slits will allow only a portion of the image to pass to the detector associated with the panel.

Abstract translation: 一种使用非相干光源（例如发光二极管（LED））和检测器来检查流式细胞仪的流动流中的颗粒的装置和方法。 发光二极管用作激发光源并朝向所述流动流发射光，并且检测器响应于撞击颗粒的激发光而从颗粒发出的光，特别是荧光。 控制器控制每个发光二极管以将激发光发射到激发光照射到感兴趣的颗粒上的预定时间段。 控制器对所检测的光进行评估以确定颗粒的特征，例如粒度，密度和粒度。 该装置和方法可以进一步采用一个或多个相干和均匀的发光器件，例如激光器作为附加的激发光源。 检测器可以检测来自颗粒的LED激发的荧光或激光激发的荧光，并且控制器可以评估两种类型的检测光以确定颗粒的特征。 此外，控制器可以控制LED以脉冲方式操作，这可以与激光激发荧光或光散射的检测同步。 此外，具有一个或多个狭缝的基本上不透明的面板可以位于流动流的图像被投影的图像平面处，使得狭缝将仅允许图像的一部分传递到与 面板。

公开(公告)号：US06806955B2

公开(公告)日：2004-10-19

申请号：US10015787

申请日：2001-12-17

Applicant: Ho Fan Jang

Inventor： Ho Fan Jang

IPC: G01J330

CPC classification number: G01N33/343 ,  G01N3/40 ,  G01N15/0227 ,  G01N15/1459 ,  G01N15/1463 ,  G01N21/6458 ,  G01N33/46 ,  G01N2015/0057 ,  G01N2015/0294 ,  G01N2015/1479 ,  G01N2015/1488 ,  G01N2015/1497 ,  G01N2021/6417 ,  G01N2203/028 ,  G01N2203/0647

Abstract: The invention relates to a fluorescence microscopy technique for measuring physical and chemical properties of individual fiber-like particles. Fluorescence intensity per unit length is shown to be proportional to the fiber coarseness. In addition, other fiber properties such as fiber length, width and wall thickness can be obtained from fluorescence images, and lignin content from fluorescence spectra. The present invention will provide a process for determining the uniformity of pulp samples in terms of the physical and chemical properties of the individual fiber-like particles, particularly wood pulp fibers.

Abstract translation: 本发明涉及用于测量单个纤维状颗粒的物理和化学性质的荧光显微技术。 每单位长度的荧光强度显示与纤维粗糙度成比例。 此外，可以从荧光图像获得纤维长度，宽度和壁厚等其他纤维性质，并从荧光光谱获得木质素含量。 本发明将提供一种用于根据单个纤维状颗粒，特别是木浆纤维的物理和化学性质确定纸浆样品的均匀性的方法。

公开(公告)号：US06804000B2

公开(公告)日：2004-10-12

申请号：US10017912

申请日：2001-12-14

Applicant: Robert Dixon Roorda ,  Gero Miesenböck

Inventor： Robert Dixon Roorda ,  Gero Miesenböck

IPC: G01J330

CPC classification number: G01N21/6458 ,  G01N21/645 ,  G01N2021/6471 ,  G02F1/33

Abstract: Method and apparatus for steering a beam of light. The method and apparatus are based on the discovery that the spectral dispersion of multi-chromatic light pulses by an acousto-optical deflector can be significantly ameliorated by positioning a dispersive element, such as a prism, along the path of the multi-chromatic light pulses in such a way that the dispersive element disperses the multi-chromatic light pulses in a direction opposite to the spectral dispersion caused by the acousto-optical deflector. The dispersive element may be positioned either before or after the acousto-optical deflector. The method and apparatus are particularly well-suited for use with ultrashort laser pulses in the visible and infrared ranges having a bandwidth of up to about 40 nm. The method and apparatus have applicability in, among other things, multi-photon laser scanning microscopy.

Abstract translation: 用于转向光束的方法和装置。 该方法和装置基于以下发现：通过将声光偏转器的多色光脉冲的光谱色散可以通过沿着多色光脉冲的路径定位诸如棱镜的色散元件来显着改善 以这样的方式使色散元件以与由光声偏转器引起的光谱色散相反的方向分散多色光脉冲。 分散元件可以位于声光偏转器之前或之后。 该方法和装置特别适用于具有高达约40nm带宽的可见光和红外范围内的超短激光脉冲。 该方法和装置尤其适用于多光子激光扫描显微镜。

公开(公告)号：US06795179B2

公开(公告)日：2004-09-21

申请号：US10336061

申请日：2003-01-03

Applicant: Pradeep Kumar

Inventor： Pradeep Kumar

IPC: G01J330

CPC classification number: B07C5/366 ,  B07C5/3425 ,  B07C2501/0054 ,  G01N21/718

Abstract: A system for sorting randomly positioned, irregularly shaped scrap metal particles on a moving conveyor employs laser-induced breakdown spectroscopy (LIBS), and includes an image detector for locating the particles as they path through a predefined viewing area, a position detector for detecting movement of the conveyor, a laser system for providing laser pulses, a scanner assembly for directing the pulses to selected locations within a target area, a light collector, a light distribution and spectral analyzer for isolating and measuring at least one selected band from the collected light, a separator, and suitable logic for identifying the particles, monitoring their position, monitoring the output of the laser and, operating the scanner assembly to direct the pulses to the identified particle. The spectral data is then analyzed, each particle is categorized, and thereafter sorted.

Abstract translation: 用于在移动的输送机上排列随机定位的不规则形状的废金属颗粒的系统采用激光诱发击穿光谱（LIBS），并且包括用于在粒子通过预定义的观察区域时定位颗粒的图像检测器，用于检测运动的位置检测器 的输送机，用于提供激光脉冲的激光系统，用于将脉冲引导到目标区域内的选定位置的扫描器组件，集光器，配光和光谱分析器，用于从收集的光分离和测量至少一个选定的带 分离器，以及用于识别颗粒，监测其位置，监测激光输出的合适逻辑，以及操作扫描器组件以将脉冲引导到所识别的颗粒。 然后分析光谱数据，对每个粒子进行分类，然后进行分类。

公开(公告)号：US06762835B2

公开(公告)日：2004-07-13

申请号：US10098368

申请日：2002-03-18

Applicant: Hansheng Zhang ,  Awadesh K. Rai ,  Jagdish P. Singh ,  Fang-Yu Yueh

Inventor： Hansheng Zhang ,  Awadesh K. Rai ,  Jagdish P. Singh ,  Fang-Yu Yueh

IPC: G01J330

CPC classification number: G01N21/718 ,  G01J3/443

Abstract: A fiber optic laser-induced breakdown spectroscopy (LIBS) sensor, including a laser light source, a harmonic separator for directing the laser light, a dichroic mirror for reflecting the laser light, a coupling lens for coupling the laser light at an input of a multimode optical fiber, a connector for coupling the laser light from an output of the multimode optical fiber to an input of a high temperature holder, such as a holder made of stainless steel, and a detector portion for receiving emission signal and analyzing LIBS intensities. In one variation, the multimode optical fiber has silica core and silica cladding. The holder includes optical lenses for collimating and focusing the laser light in a molten alloy to produce a plasma, and for collecting and transmitting an emission signal to the multimode optical fiber.

Abstract translation: 一种光纤激光诱发击穿光谱（LIBS）传感器，包括激光光源，用于引导激光的谐波分离器，用于反射激光的分色镜，耦合透镜，用于将激光耦合在 多模光纤，用于将来自多模光纤的输出的激光耦合到诸如由不锈钢制成的保持器的高温保持器的输入端的连接器以及用于接收发射信号和分析LIBS强度的检测器部分。 在一个变型中，多模光纤具有二氧化硅芯和二氧化硅包层。 保持器包括用于将激光准直和聚焦在熔融合金中以产生等离子体的光学透镜，并用于收集和发射发射信号到多模光纤。