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    METHOD FOR DETERMINING RED CELL ADDITIVE SOLUTION VOLUME
    54.
    发明申请
    METHOD FOR DETERMINING RED CELL ADDITIVE SOLUTION VOLUME 有权

    公开(公告)号：US20250049995A1

    公开(公告)日：2025-02-13

    申请号：US18797694

    申请日：2024-08-08

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  Kyungyoon Min

    IPC: A61M1/02

    Abstract: Automated blood processing systems and methods including a durable hardware component, a single use fluid flow circuit, and a controller configured to determine and add a custom amount of additive solution. More particularly, systems and methods for adding a custom amount of a red blood cell (RBC) additive solution to obtain a target RBC product with a target hematocrit.

    Configurable System To Automate Blood Component Manufacturing Processes
    55.
    发明公开
    Configurable System To Automate Blood Component Manufacturing Processes 审中-公开

    公开(公告)号：US20240226396A1

    公开(公告)日：2024-07-11

    申请号：US17909799

    申请日：2021-03-17

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  Richard I. Brown ,  Kyungyoon Min

    IPC: A61M1/02 ,  A61M1/36

    CPC classification number: A61M1/0272 ,  A61M1/3643 ,  A61M2205/3331 ,  A61M2205/505

    Abstract: A configurable automated blood component manufacturing system includes a durable hardware component and a single use fluid flow circuit. The hardware component includes a pump station, a centrifuge, and a controller including a touchscreen. The hardware component further includes hangers for suspending containers, a weight scale associated with each hanger, a plurality of tubing clamps, and a cassette nesting module including a plurality of valves and pressure sensors. The fluid flow circuit includes a separation chamber received in the centrifuge, a fluid flow control cassette mounted in the cassette nesting module, and a plurality of containers in fluid communication with the fluid flow cassette. The controller is pre-programmed to automatically operate the system to perform one or more standard blood processing procedures selected by an operator by input to the touchscreen, and is configured to be further programmed by the operator to perform additional blood processing procedures.

    Temperature-Based Adjustment Of Centrifugal Blood Separation Procedure Parameters
    56.
    发明公开
    Temperature-Based Adjustment Of Centrifugal Blood Separation Procedure Parameters 审中-公开

    公开(公告)号：US20240139398A1

    公开(公告)日：2024-05-02

    申请号：US18379307

    申请日：2023-10-12

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  Richard I. Brown ,  Kyungyoon Min

    IPC: A61M1/36

    CPC classification number: A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0429 ,  A61M2205/3334 ,  A61M2205/3368

    Abstract: A blood processing device includes a pump system, a valve system, a centrifuge, and a controller configured and/or programmed to control the operation of the pump system, the valve system, and the centrifuge to execute a blood separation procedure. The blood separation procedure executed by the controller includes pumping blood into the centrifuge at an inflow rate, separating the blood in the centrifuge into red blood cells and plasma, with an interface between the red blood cells and plasma located at an interface position within the centrifuge, and pumping at least a portion of the red blood cells and at least a portion of the plasma out of the centrifuge. The controller is configured and/or programmed to employ an inflow rate and/or an interface position that is based at least in part on the temperature of the blood.

    Centrifugal Separation And Collection Of Red Blood Cells And Plasma
    57.
    发明公开
    Centrifugal Separation And Collection Of Red Blood Cells And Plasma 审中-公开

    公开(公告)号：US20240115777A1

    公开(公告)日：2024-04-11

    申请号：US18391085

    申请日：2023-12-20

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  Kyungyoon Min

    IPC: A61M1/02 ,  A61M1/36 ,  B04B5/04

    CPC classification number: A61M1/029 ,  A61M1/362227 ,  A61M1/36224 ,  A61M1/36225 ,  A61M1/362261 ,  A61M1/362265 ,  A61M1/3693 ,  A61M1/3696 ,  B04B5/0442 ,  B04B11/02

    Abstract: Systems and methods are provided for separating blood into two or more components for collection of red blood cells, plasma, or both red blood cells and plasma. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit, with the blood being separated into its constituents by the centrifugal separator. Separated plasma may be collected following separation by the centrifugal separator or may first be conveyed from the centrifugal separator into the spinning membrane separator drive unit to separate cellular blood components from the plasma prior to collection of the filtered plasma. The cellular blood components filtered from the plasma may be retained in the circuit as a waste product or may be flushed out of the circuit to a recipient.

    OPTIMIZATION OF FLUID POOLING
    58.
    发明公开
    OPTIMIZATION OF FLUID POOLING 审中-公开

    公开(公告)号：US20230285643A1

    公开(公告)日：2023-09-14

    申请号：US18181023

    申请日：2023-03-09

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters ,  Kyungyoon Min

    IPC: A61M1/02

    CPC classification number: A61M1/0209 ,  A61M2202/0427 ,  A61M2205/3306

    Abstract: A method (and a system for implementing such method) for creating a plurality of fluid products each having a minimum content of a fluid component includes providing a plurality of intermediate fluid volumes each having a known content of a fluid component. The intermediate fluid volumes are grouped by fluid component content, followed by a determination of whether two of the intermediate fluid volumes may be pooled to achieve the minimum content for a final fluid product. The method proceeds with creating combinations of three and then more intermediate fluid volumes achieving the minimum content for a final fluid product, followed by creating combinations of intermediate fluid volumes exceeding the minimum content. Each intermediate fluid volume is assigned to only one of the combinations, with the intermediate fluid volumes being assigned to the combinations so as to maximize the number of combinations and, thus, the number of final fluid products.

    SYSTEMS AND METHODS FOR INDUCING PLUG FLOW DURING FLUID SEPARATION USING AIR
    59.
    发明公开
    SYSTEMS AND METHODS FOR INDUCING PLUG FLOW DURING FLUID SEPARATION USING AIR 审中-公开

    公开(公告)号：US20230270929A1

    公开(公告)日：2023-08-31

    申请号：US18174926

    申请日：2023-02-27

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters

    IPC: A61M1/36 ,  B01D21/26

    CPC classification number: A61M1/3693 ,  B01D21/262 ,  B01D2221/10

    Abstract: A fluid separation system and method includes a durable hardware component including a pump station with plurality of pumps, a centrifuge mounting station and drive unit, a plurality of valves and clamps, and a controller. The system includes a single use fluid flow circuit having a separation chamber configured to be received by the centrifuge and the fluid flow circuit is engageable with the durable hardware component to control fluid flow within the fluid flow circuit. The fluid flow circuit having an air access component configured to selectively receive air and to provide the air into a conduit to induce plug flow between the separated fluid component and another separated fluid component, wherein the controller is configured to operate the system to perform one or more blood processing procedures to convey a fluid into the separation chamber and to remove a separated fluid component from the separation chamber.

    SYSTEMS AND METHODS FOR FLUID SEPARATION INTERFACE CONTROL USING COLOR-BASED OPTICAL MEASUREMENTS
    60.
    发明公开
    SYSTEMS AND METHODS FOR FLUID SEPARATION INTERFACE CONTROL USING COLOR-BASED OPTICAL MEASUREMENTS 审中-公开

    公开(公告)号：US20230226562A1

    公开(公告)日：2023-07-20

    申请号：US18153473

    申请日：2023-01-12

    Applicant: Fenwal, Inc.

    Inventor： Benjamin E. Kusters

    IPC: B04B11/02 ,  G01N13/00 ,  B04B5/04 ,  A61M1/36

    CPC classification number: B04B11/02 ,  G01N13/00 ,  B04B5/0442 ,  A61M1/3693 ,  B04B2013/006

    Abstract: A fluid separation device includes a centrifugal separator configured to receive a centrifugal separation chamber of a disposable fluid flow circuit, a pump system configured to convey a fluid into the centrifugal separation chamber and to remove a separated fluid component from the centrifugal separation chamber via an outlet, a color-based interface monitoring system configured to determine an interface position between separated fluid components continuously flowing through the centrifugal separation chamber based on dominant wavelength measurements of layers of separated fluid components during a centrifugal separation procedure, and a controller configured to measure the dominant wavelengths of the layers, calculate a duration as a color time for each measured dominant wavelength, set target color times, calculate error signals and calculate control signals to adjust the pump system to control the flow rate and interface position.

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