公开(公告)号：US20160151508A1

公开(公告)日：2016-06-02

申请号：US15018068

申请日：2016-02-08

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Venkatesh Chelvam ,  Youngsoon Kim ,  Sumith A. Kularatne

IPC: A61K47/48 ,  A61K51/08 ,  A61K49/00 ,  C12N9/48 ,  A61K38/15 ,  A61K31/4745 ,  A61K31/475 ,  C12N9/96 ,  A61K39/00 ,  A61K31/454

CPC classification number: C12N9/485 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/475 ,  A61K38/00 ,  A61K47/542 ,  A61K49/0032 ,  A61K49/0052 ,  A61K51/0402 ,  C12N9/96 ,  C12Y304/17021

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

Abstract translation: 本文描述了可用于递送治疗，诊断和成像剂的前列腺特异性膜抗原（PSMA）结合缀合物。 本文还描述了含有它们的药物组合物和使用缀合物和组合物的方法。 还描述了制备缀合物和含有它们的组合物的方法。

公开(公告)号：US09333270B2

公开(公告)日：2016-05-10

申请号：US14010098

申请日：2013-08-26

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Sumith A. Kularatne ,  Sakkarapalayam M. Mahalingam

IPC: A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00 ,  G01N33/569 ,  G01N33/566 ,  G01N33/50 ,  G01N33/58 ,  G01N33/68

CPC classification number: A61K49/0052 ,  A61K49/001 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  C07D475/04 ,  G01N21/6428 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/582 ,  G01N33/6893 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2333/705 ,  G01N2800/24

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

公开(公告)号：US09180215B2

公开(公告)日：2015-11-10

申请号：US14058567

申请日：2013-10-21

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  A61K51/08 ,  A61K51/04 ,  C07B59/00 ,  C07D475/04

CPC classification number: A61K51/088 ,  A61K51/0497 ,  C07B59/002 ,  C07D475/04

Abstract: Described herein are compositions and methods for diagnosing and/or monitoring pathogenic disease states using positron emission tomography, wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. Also described herein are 18F conjugates of vitamins and vitamin receptor-binding analogs and derivatives.

Abstract translation: 本文描述了使用正电子发射断层扫描来诊断和/或监测致病性疾病状态的组合物和方法，其中致病细胞独特地表达，优先表达或过量表达维生素受体。 本文还描述了维生素和维生素受体结合类似物和衍生物的18F缀合物。

公开(公告)号：US20140112866A1

公开(公告)日：2014-04-24

申请号：US14058567

申请日：2013-10-21

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip S. Low ,  Sumith A. Kularatne

IPC: A61K51/08

CPC classification number: A61K51/088 ,  A61K51/0497 ,  C07B59/002 ,  C07D475/04

Abstract: Described herein are compositions and methods for diagnosing and/or monitoring pathogenic disease states using positron emission tomography, wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. Also described herein are 18F conjugates of vitamins and vitamin receptor-binding analogs and derivatives.

Abstract translation: 本文描述了使用正电子发射断层扫描来诊断和/或监测致病性疾病状态的组合物和方法，其中致病细胞独特地表达，优先表达或过量表达维生素受体。 本文还描述了维生素和维生素受体结合类似物和衍生物的18F缀合物。