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    Compounds for positron emission tomography
    51.
    发明授权
    Compounds for positron emission tomography 有权

    公开(公告)号：US12178892B2

    公开(公告)日：2024-12-31

    申请号：US17488810

    申请日：2021-09-29

    Applicant: Endocyte, Inc. ,  Purdue Research Foundation

    Inventor： Iontcho R Vlahov ,  Christopher P Leamon ,  Philip S. Low ,  Garth L Parham ,  Qingshou Chen

    IPC: A61K51/04

    Abstract: Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group.

    Micro-fluidic system using micro-apertures for high throughput detection of cells
    52.
    发明授权
    Micro-fluidic system using micro-apertures for high throughput detection of cells 有权

    公开(公告)号：US11478797B2

    公开(公告)日：2022-10-25

    申请号：US16420412

    申请日：2019-05-23

    Applicant: Purdue Research Foundation

    Inventor： Cagri A. Savran ,  Philip S. Low ,  Chun-Li Chang

    IPC: B01L3/00 ,  G01N33/574 ,  G01N33/543 ,  G01N27/74 ,  G01N1/40

    Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target cells bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target cells from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target cells bound to magnetic beads on the surface of the plate. The microfluidic detection system includes a pump flowing the fluid through the detector component at high flow rates of milliliters per minute for high throughput detection of target cells.

    Micro-fluidic system using micro-apertures for high throughput detection of cells
    56.
    发明授权
    Micro-fluidic system using micro-apertures for high throughput detection of cells 有权

    公开(公告)号：US11077439B2

    公开(公告)日：2021-08-03

    申请号：US16275912

    申请日：2019-02-14

    Applicant: Purdue Research Foundation

    Inventor： Cagri A. Savran ,  Philip S. Low ,  Chun-Li Chang ,  Wanfeng Huang

    IPC: G01N33/553 ,  B01L3/00 ,  G01N33/574 ,  G01N33/543 ,  G01N27/74 ,  G01N1/40

    Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target entities bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target entities from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target entities bound to magnetic beads on the surface of the plate. In a further feature, the microfluidic detection system is configured to pass target molecules through the plate to be bound to a functionalized surface of the lower chamber.

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