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    Gating device and driver for modulation of charged particle beams
    56.
    发明授权
    Gating device and driver for modulation of charged particle beams 失效
    用于调制带电粒子束的门控装置和驱动器

    公开(公告)号：US07456391B2

    公开(公告)日：2008-11-25

    申请号：US11411393

    申请日：2006-04-25

    Applicant: Richard N. Zare ,  Facundo M. Fernandez ,  Joel R. Kimmel ,  Oliver Trapp

    Inventor： Richard N. Zare ,  Facundo M. Fernandez ,  Joel R. Kimmel ,  Oliver Trapp

    IPC: B01D59/44

    CPC classification number: H01J49/061 ,  H01J49/40

    Abstract: By connecting the Bradbury-Nielson gate (BNG) directly to a driver without a transmission line, distortion of the voltage waveform experienced a the BNG are much reduced. Because the magnitude of the modulation defects grows as the applied modulation voltage is increased, Bradbury-Nielson gates with finer wire spacing such as 100 microns, and operating at 10 to 15 V, significantly better signal-to-noise ratios are achieved. HT-TOFMS data were also post processed using an exact knowledge of the modulation defects.

    Abstract translation: 通过将Bradbury-Nielson门（BNG）直接连接到没有传输线的驱动器，经历BNG的电压波形的失真大大减少。 由于调制缺陷的幅度随着施加的调制电压的增加而增加，所以Bradbury-Nielson门具有更细的导线间距，例如100微米，并且在10至15V下工作，实现了明显更好的信噪比。 HT-TOFMS数据也使用调制缺陷的确切知识进行后处理。

    Immobilized-enzyme microreactor devices for characterization of biomolecular analytes and associated methods
    58.
    发明申请
    Immobilized-enzyme microreactor devices for characterization of biomolecular analytes and associated methods 审中-公开
    用于表征生物分子分析物和相关方法的固定酶微反应器装置

    公开(公告)号：US20070284308A1

    公开(公告)日：2007-12-13

    申请号：US11451711

    申请日：2006-06-12

    Applicant: Richard N. Zare ,  Maria T. Dulay

    Inventor： Richard N. Zare ,  Maria T. Dulay

    IPC: B01D15/08

    CPC classification number: B01J20/261 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28042 ,  B01J20/28047 ,  B01J20/28085 ,  B01J20/3064 ,  B01J20/3208 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3246 ,  B01J20/3257 ,  B01J20/3274 ,  B01J2220/44 ,  B01J2220/54 ,  B01J2220/58 ,  B01J2220/64 ,  B01J2220/66 ,  B01J2220/82 ,  B01J2220/84

    Abstract: A method that comprises providing a polymerized sol-gel material (PSG) and linking an enzyme to a surface of the PSG via covalent linkage is provided. The surface of the PSG is derivatized with a linker that comprises a functional group for linking itself to the surface of the PSG and a functional group for linking itself with the enzyme. The linked-enzyme PSG, or microreactor, is an effective means of at least partially digesting a substrate, such as a biological substrate. The activity of the enzyme of the microreactor may be significantly enhanced, up to 200-fold to over 2000-fold, for example, relative to the activity of the enzyme free of the microreactor. The microreactor is thus an effective vehicle for digesting a substrate such as a biomolecule, a protein, an oligonucleotide, a peptide, a steroid, and/or an organic acid, after which, any remaining substrate and one or more digestion product(s) may be separated and detected. Microreactors and integrated devices that incorporate microreactors, such as chips, columns, pipet tips, wells, and well-plates, are also provided.

    Abstract translation: 提供了一种包括提供聚合的溶胶 - 凝胶材料（PSG）并通过共价键将酶与PSG的表面连接的方法。 PSG的表面用包含用于将其自身连接到PSG表面的官能团的接头衍生化，以及将其自身与酶连接的官能团。 连接酶PSG或微反应器是至少部分消化底物如生物底物的有效手段。 相对于不含微反应器的酶的活性，微反应器的酶的活性可以显着提高，高达200倍至超过2000倍。 因此，微反应器是用于消化诸如生物分子，蛋白质，寡核苷酸，肽，类固醇和/或有机酸的底物的有效载体，之后，任何残留的底物和一种或多种消化产物， 可能被分离和检测。 还提供了包含微反应器的微反应器和集成器件，例如芯片，色谱柱，移液管吸头，孔和孔板。

    Microfabricated beam modulation device
    59.
    发明授权
    Microfabricated beam modulation device 失效
    微型光束调制装置

    公开(公告)号：US07176452B2

    公开(公告)日：2007-02-13

    申请号：US11107583

    申请日：2005-04-15

    Applicant: Ignacio A. Zuleta ,  Richard N. Zare

    Inventor： Ignacio A. Zuleta ,  Richard N. Zare

    IPC: H01J1/46 ,  H01L21/46 ,  H01L23/48

    CPC classification number: H01J49/061 ,  H01J49/0018 ,  H01L2924/0002 ,  H01L2924/00

    Abstract: A beam modulation device gate is constructed from a silicon material, such as a silicon layer on an silicon on insulator wafer. The device further comprises a set of electrical contacts on the layer. The layer defines a set of electrically conducting silicon material fingers forming an array, wherein each of at least some of the fingers is connected electrically to one of the electrical contacts. The gate may be used in a mass or ion mobility spectrometer. Where the gate is constructed from a silicon on insulator wafer, an insulator layer supports the silicon layer and a handle layer supports the insulator layer. When predetermined electrical potentials are applied to the electrical contacts, at least some of the fingers will be substantially at said predetermined electrical potentials to modulate a beam of charged particles that passes through said array of fingers. A plurality of devices of the type above may be used, where each of the devices modulates the beam so that the beam is deflected along a direction different from direction along which the beam is deflected by any of the remaining devices. A plurality of devices of the type above may be used for a mass gate or charged particle buncher device. For making an ion optical device, an array of fingers is formed in a silicon layer of the silicon on insulator wafer. A portion of a handle layer of the wafer on a side of an insulator layer of the wafer opposite to that of the fingers is removed; and a portion of the insulator layer is removed so that the fingers are connected to the wafer only through the silicon layer and at one end of the fingers.

    Abstract translation: 光束调制器件栅极由诸如硅绝缘体晶片上的硅层的硅材料构成。 该装置还包括该层上的一组电触点。 该层限定了一组形成阵列的导电硅材料指状物，其中至少一些指状物中的每一个与电触点之一电连接。 栅极可用于质谱或离子迁移谱仪。 在栅极由硅绝缘体晶片构成的情况下，绝缘体层支撑硅层，并且手柄层支撑绝缘体层。 当预定的电势被施加到电触点时，至少一些指状物将基本处于所述预定的电势，以调制穿过所述指状物阵列的带电粒子束。 可以使用上述类型的多个装置，其中每个装置调制光束，使得光束沿着不同于任何剩余装置偏转光束的方向的方向偏转。 上述类型的多个装置可以用于质量门或带电粒子聚束器装置。 为了制造离子光学器件，在硅绝缘体晶片的硅层中形成指状物阵列。 除去晶片的与手指相反的晶片的绝缘体层一侧的手柄层的一部分; 并且去除绝缘体层的一部分，使得指状物仅通过硅层和手指的一端连接到晶片。

    Analog detection for cavity lifetime spectroscopy
    60.
    发明授权
    Analog detection for cavity lifetime spectroscopy 有权
    空腔寿命光谱的模拟检测

    公开(公告)号：US06532071B2

    公开(公告)日：2003-03-11

    申请号：US09755253

    申请日：2001-01-04

    Applicant: Richard N. Zare ,  Charles C. Harb ,  Barbara A. Paldus ,  Thomas G. Spence

    Inventor： Richard N. Zare ,  Charles C. Harb ,  Barbara A. Paldus ,  Thomas G. Spence

    IPC: G01N2117

    CPC classification number: G01N21/39

    Abstract: An analog detection system for determining a ring-down rate or decay rate 1/&tgr; of an exponentially decaying ring-down beam issuing from a lifetime or ring-down cavity during a ring-down phase. Alternatively, the analog detection system determines a build-up rate of an exponentially growing beam issuing from the cavity during a ring-up phase. The analog system can be employed in continuous wave cavity ring-down spectroscopy (CW CRDS) and pulsed CRDS (P CRDS) arrangements utilizing any type of ring-down cavity including ring-cavities and linear cavities.

    Abstract translation: 一种模拟检测系统，用于确定在衰落阶段期间从寿命或衰落腔中发出的指数衰减衰减波束的衰减速率或衰减速率1 /τ。 或者，模拟检测系统确定在振铃阶段期间从空腔发出的指数增长的光束的累积速率。 模拟系统可用于连续波腔衰减光谱（CW CRDS）和脉冲CRDS（P CRDS）布置，利用任何类型的环形腔包括环形腔和线性腔。

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