公开(公告)号：US11107963B2

公开(公告)日：2021-08-31

申请号：US15865644

申请日：2018-01-09

Applicant: Academia Sinica

Inventor： Maw-Kuen Wu ,  Phillip M Wu ,  Yang-Yuan Chen ,  Chung-Chieh Chang ,  Pai-Chun Wei ,  Tian-Wey Lan ,  Yu-Ruei Wu

IPC: H01L35/16 ,  H01L35/26 ,  H01L35/34 ,  C01B19/00

Abstract: At least one of the present embodiments generally relates to an apparatus and a method for enhancing the figure of merit (zT) in composite thermoelectric materials using aerogel such as e.g., silicate/silica aerogel, carbon aerogel, chalcogenide aerogel and metal oxide aerogel. For example, the present embodiments provide apparatuses and methods for the addition of aerogels to two commonly used p and n type thermoelectric materials and thereby enhancing their thermoelectric figure of merits to record levels.

公开(公告)号：US20210198332A1

公开(公告)日：2021-07-01

申请号：US17105858

申请日：2020-11-27

Applicant: ACADEMIA SINICA

Inventor： Benjamin Pang-Hsien TU ,  Rita PY CHEN ,  Joseph Jen-Tse HUANG ,  Yijuang CHERN ,  Yu-Song JANG ,  Xiang-Me LAI ,  Tai-Yan LIAO ,  Te-Hsien KUNG

IPC: C07K14/47

Abstract: Bipartite molecules comprising a peptide affinity moiety and at least one charged moiety and uses thereof in reducing formation of abnormal protein aggregate and treating diseases associated with such abnormal protein aggregate, including neurodegenerative disease characterized by formation of protein aggregates.

公开(公告)号：US11040111B2

公开(公告)日：2021-06-22

申请号：US16111242

申请日：2018-08-24

Applicant: ACADEMIA SINICA ,  KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Steven R Roffler ,  Tian-Lu Cheng ,  Chien-Han Kao ,  Bing-Mae Chen ,  Yu-Cheng Su ,  Hsin-Yi Tung ,  Kuo-Hsiang Chuang

IPC: C07K16/00 ,  A61K47/68 ,  C07K16/44 ,  C07K16/32 ,  C07K16/30 ,  C07K16/28 ,  A61K49/00 ,  A61K47/69 ,  A61K39/395 ,  A61K47/60 ,  A61K39/00

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

公开(公告)号：US20210154319A9

公开(公告)日：2021-05-27

申请号：US16111242

申请日：2018-08-24

Applicant: ACADEMIA SINICA ,  KAOHSIUNG MEDICAL UNIVERSITY

Inventor： STEVEN R ROFFLER ,  TIAN-LU CHENG ,  CHIEN-HAN KAO ,  BING-MAE CHEN ,  YU-CHENG SU ,  HSIN-YI TUNG ,  Kuo-Hsiang Chuang

IPC: A61K47/68 ,  C07K16/32 ,  A61K49/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/44

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

公开(公告)号：US20210150148A1

公开(公告)日：2021-05-20

申请号：US17099867

申请日：2020-11-17

Applicant: ACADEMIA SINICA

Inventor： WEN-LIAN HSU

IPC: G06F40/30 ,  G06F40/295 ,  G06F40/263 ,  G06F40/284 ,  G06F40/253 ,  G06F40/58

Abstract: A natural language processing method, comprising: receiving multiple input words; and reducing the multiple words into one or more subject word data structures according to sets stored in a database, wherein one of the subject word data structures includes a first input word and a second input words among the input words, wherein one of the sets includes a compatible relation between the first input word and the second input word, wherein the compatible relation between the first input word and the second word includes a compatible property for denoting an intensity representing occurrences of the first input word and the second word in a training corpus.

公开(公告)号：US10998175B2

公开(公告)日：2021-05-04

申请号：US16686203

申请日：2019-11-17

Applicant: Academia Sinica

Inventor： Abdil Ozdemir ,  Jung-Lee Lin ,  Chung-Hsuan Chen

IPC: H01J49/00 ,  H01J49/16 ,  H01J49/06

Abstract: Disclosed herein is a device for characterizing a biological sample or an airborne sample. According to embodiments of the present disclosure, the device comprises an electrospray source, a mass analyzer, a charge detector, and optionally, an ion guide. The present device is useful in analyzing the particle population in the biological or airborne sample based on the mass to charge (m/z) ratio and the charge (z) of each particle. Also disclosed herein are the methods of making a diagnosis of cancer by use of the present device, and methods of determining the mass distribution of particles in an airborne sample.

公开(公告)号：US20210123927A1

公开(公告)日：2021-04-29

申请号：US17084125

申请日：2020-10-29

Applicant: National Defense Medical Center ,  Academia Sinica

Inventor： Ann CHEN ,  Shuk-Man KA ,  Shih-Hsiung WU

IPC: G01N33/68

Abstract: The present invention provides a lectin from Crenomytilus grayanus or Mytilus trossulus as diagnostic reagents for IgA nephropathy. The present invention also provides a diagnostic kit for detecting Galactose-deficient IgA1 (Gd-IgA1), comprising RussiaSea-001 (also called as CGL) isolated from Crenomytilus grayanus or RussiaSea-002 (also called as MTL) isolated from Mytilus trossulus. The present invention further provides a method for detecting Gd-IgA1 using RussiaSea-001 or RussiaSea-002

公开(公告)号：US20210101939A1

公开(公告)日：2021-04-08

申请号：US16932372

申请日：2020-07-17

Applicant: Academia Sinica

Inventor： Chiaho Shih ,  Heng-Li Chen ,  Pei-Yi Su

IPC: C07K14/005 ,  A01N37/46 ,  A01N63/00 ,  C07K7/08 ,  A61P31/04

Abstract: An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.

公开(公告)号：US10941130B2

公开(公告)日：2021-03-09

申请号：US16362172

申请日：2019-03-22

Applicant: ACADEMIA SINICA

Inventor： Po-Wen Chung ,  Prasenjit Bhaumik ,  Hao-Ju Chou

IPC: C07D307/46 ,  B01J8/06 ,  B01D3/10 ,  C01D15/10

Abstract: This invention relates to a novel molten salt system in chemical transformation of saccharides and a method as well as an apparatus for multi carbon production by the molten salt system. It is found that an eutectic molten salt composition is advantageous for multi-carbon productions through chemical transformation under mild conditions. This invention further provides a method and an apparatus for preparing 5-hydroxymethylfurfural (HMF) and HMF-derived chemicals from saccharides by the said molten salt system.

公开(公告)号：US20210063587A1

公开(公告)日：2021-03-04

申请号：US16557268

申请日：2019-08-30

Applicant: NATIONAL SYNCHROTRON RADIATION RESEARCH CENTER ,  ACADEMIA SINICA

Inventor： BING-MING CHENG ,  HSIAO-CHI LU ,  JEN-IU LO ,  HUAN-CHENG CHANG

IPC: G01T1/202 ,  G01J1/42 ,  H01L31/09 ,  H01L31/0232 ,  G01J1/58

Abstract: The present disclosure provides a fluorescent nitrogen-vacancy diamond (FNVD) having a plurality of nitrogen-vacancy centers with a concentration about 1 ppm to 10,000 ppm. The FNVD as built-in fluorophores exhibit a nearly constant emission profile over 540 nm to 850 nm upon excitation by vacuum ultraviolet (VUV), extreme ultraviolet (EUV) and X-rays for the energy larger than 6.2 eV. Applying the FNVD sensor can measure VUV/EUV/X-rays as a sensing sheet, manufacturing method and uses thereof, sensor and lithography apparatus. The superb photostability and broad applicability of FNVDs offer a promising solution for the long-standing problem of lacking robust and reliable detectors for VUV, EUV, and X-rays.