公开(公告)号：US5096835A

公开(公告)日：1992-03-17

申请号：US520093

申请日：1990-05-07

Applicant: Yasuhiko Yokomori ,  Masato Ohta ,  Masahide Kimura ,  Kunio Kurata ,  Yoshinobu Kubo ,  Yoshiharu Matsuoka

Inventor： Yasuhiko Yokomori ,  Masato Ohta ,  Masahide Kimura ,  Kunio Kurata ,  Yoshinobu Kubo ,  Yoshiharu Matsuoka

IPC: G01N33/543 ,  G01N21/17 ,  G01N21/59 ,  G01N21/82

CPC classification number: G01N21/82 ,  G01N2021/5957 ,  G01N2201/04 ,  Y10S436/805

Abstract: The aggregation pattern of particles is determined by obtaining luminous intensity curves representative of the particle aggregation pattern, obtaining a first threshold face by cutting the curves with a plane positioned at a first given height, obtaining a second threshold face by cutting the curves with a plane positioned at a second given height and determining the particle aggregation pattern by calculating the ratio of the area of the first threshold face to the area of the second threshold face.

Abstract translation: 通过获得表示颗粒聚集图案的亮度曲线来确定颗粒的聚集图案，通过用位于第一给定高度的平面切割曲线获得第一阈值面，通过用平面切割曲线获得第二阈值面 定位在第二给定高度，并通过计算第一阈值面积的面积与第二阈值面积的面积的比率来确定粒子聚集模式。

公开(公告)号：US5059025A

公开(公告)日：1991-10-22

申请号：US500972

申请日：1990-03-29

Applicant: Osamu Ando

Inventor： Osamu Ando

IPC: G01N21/13 ,  G01N21/25

CPC classification number: G01N21/253 ,  G01N2201/04

Abstract: A spectrophotometer having a movable sample cell holder, formed with position detecting through-holes, for holding sample cells and a detector for measuring the light transmitting the through-hole to detect a position of the holder.

公开(公告)号：US4939095A

公开(公告)日：1990-07-03

申请号：US370079

申请日：1989-06-22

Applicant: Noboru Yokotani

Inventor： Noboru Yokotani

IPC: G01N21/75 ,  G01N21/27 ,  G01N21/41 ,  G01N21/59 ,  G01N35/02 ,  G01N35/10

CPC classification number: G01N21/59 ,  G01N21/274 ,  G01N35/1002 ,  G01N2201/04 ,  G01N2201/12753 ,  Y10T436/113332

Abstract: An automatic chemical analyzer has a compensation coefficient calculating section and a light-path-length-based compensating section. The calculating section obtains the ratio of the absorbancies measured of reaction cells filled with a sample of the known absorbancy to the absorbancy measured of each cell, thereby calculating compensation coefficients for the respective cells. The compensating section multiplies the absorbancies measured of the cells refilled with samples of different unknown absorbancies by the compensation coefficients calculated by the calculating section, thereby compensating the absorbancies for the light path lengths of the cells. The compensated absorbancies, i.e., the absorbancies of the samples, are used in analyzing the samples.

Abstract translation: 自动化学分析仪具有补偿系数计算部和光路长度补偿部。 计算部分获得了填充有已知吸光度的样品的反应池的吸光度与每个单元的测量吸收度的比率，由此计算各个单元的补偿系数。 补偿部分将由不同未知吸收值的样品重新填充的单元的测量吸收值乘以由计算部分计算出的补偿系数，由此补偿单元的光路长度的吸收率。 补偿的吸收率，即样品的吸收率，用于分析样品。

公开(公告)号：US4665553A

公开(公告)日：1987-05-12

申请号：US605732

申请日：1984-05-01

Applicant: Russell J. Gershman ,  Robert A. Hoffman ,  J. Garland O'Connell

Inventor： Russell J. Gershman ,  Robert A. Hoffman ,  J. Garland O'Connell

IPC: G01N33/49 ,  G01N15/14 ,  G01N21/59 ,  G01N33/48 ,  G06K9/00

CPC classification number: G01N15/1456 ,  G01N2021/4704 ,  G01N21/59 ,  G01N2201/04

Abstract: Samples are prepared and applied to a cuvette, and the cuvette is translated in a given direction. Laser light is coupled to the sample through a Bragg cell, which causes the beam to scan the sample transversely to the given direction. Select optical parameters are monitored, and when they occur, the scan is stopped or slowed for a more complete analysis of the illuminated cell.

Abstract translation: 制备样品并将其应用于比色皿，并将反应杯沿给定方向平移。 激光通过布拉格细胞耦合到样品，这使得光束横向于给定方向扫描样品。 选择光学参数进行监控，当它们发生时，扫描被停止或减慢，以便对照明单元进行更完整的分析。

公开(公告)号：US12085583B2

公开(公告)日：2024-09-10

申请号：US17319842

申请日：2021-05-13

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Michael Chen ,  Pey-Jiun Ko

IPC: G01N33/00 ,  B01L3/00 ,  B01L3/02 ,  B01L7/00 ,  B01L9/00 ,  B01L9/06 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1433 ,  G01N21/25 ,  G01N21/27 ,  G01N33/543 ,  G01N33/569 ,  G01N33/62 ,  G01N33/68 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N15/01 ,  G01N15/10 ,  G01N15/14 ,  G01N33/50

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5027 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/543 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1433 ,  G01N21/25 ,  G01N21/27 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56972 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  B01L9/52 ,  B01L2300/1827 ,  B01L2300/1855 ,  G01N2015/012 ,  G01N2015/016 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N33/5005 ,  G01N35/00 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US11885801B2

公开(公告)日：2024-01-30

申请号：US17407154

申请日：2021-08-19

Applicant: The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： David A. Kidwell

IPC: G01N33/543 ,  G01N33/52 ,  G01N21/29 ,  G01N21/78

CPC classification number: G01N33/54388 ,  G01N21/29 ,  G01N21/78 ,  G01N33/525 ,  G01N2201/04

Abstract: The present invention provides for a release system for delaying application of chemical reagents in a lateral-flow immunoassay. A chemistry release fiber comprising a permeable membrane and a chemical release agent is used to delay chemical reagent delivery to the indicator of a lateral-flow immunoassay. Also disclosed is the related method of delaying application of chemical reagents in a lateral-flow immunoassay.

公开(公告)号：US20180230511A1

公开(公告)日：2018-08-16

申请号：US15715063

申请日：2017-09-25

Applicant: Life Technologies Corporation

Inventor： Jeffrey Marks

IPC: C12Q1/686 ,  G01N21/64 ,  G01N21/27

CPC classification number: C12Q1/686 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/068 ,  G01N2201/12746

Abstract: The present teachings relate to a method and system for normalizing spectra across multiple instruments. In an embodiment of the present invention, the method comprises at least one reference instrument and a test instrument. Each instrument comprises at least one excitation filter and at least one emission filter arranged in pairs. Each instrument further comprises a pure dye plate comprising a plurality of wells. Each well contains a plurality of dyes where each dye comprises a fluorescent component. Fluorescent spectra are obtained from each instrument for each dye across multiple filter combinations to contribute to a pure dye matrix Mref for the reference instrument and pure dye matrix M for the test instrument. The pure dye spectra can then be multiplied by correction factors for each filter pair to result in corrected pure dye spectra, then normalized and the multicomponenting data can be extracted.

公开(公告)号：US10018643B2

公开(公告)日：2018-07-10

申请号：US14848775

申请日：2015-09-09

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Chinmay Pangarkar ,  Samartha Anekal ,  John K. Frankovich ,  Michael Chen ,  Timothy Smith

IPC: C40B30/04 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B01L7/00 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/80 ,  G01N21/25 ,  B01L9/06 ,  B01L9/00 ,  G01N15/14 ,  G01N33/543 ,  B01L3/02 ,  B01L3/00 ,  G01N21/27 ,  C12Q1/42 ,  C12Q1/52 ,  G01N33/62 ,  G01N33/68 ,  G01N33/92 ,  G01N33/50 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US09952240B2

公开(公告)日：2018-04-24

申请号：US14872995

申请日：2015-10-01

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Michael Chen ,  Pey-Jiun Ko

IPC: C40B30/04 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  B01L7/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/80 ,  G01N21/25 ,  B01L9/06 ,  G01N33/543 ,  B01L3/02 ,  B01L3/00 ,  G01N21/27 ,  C12Q1/42 ,  C12Q1/52 ,  G01N33/62 ,  G01N33/68 ,  G01N33/92 ,  G01N33/50 ,  B01L9/00 ,  G01N15/00 ,  G01N15/14 ,  G01N15/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US09797878B2

公开(公告)日：2017-10-24

申请号：US14577257

申请日：2014-12-19

Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION

Inventor： Alexander Alexandrovich Burukhin ,  Anna Viktorovna Zharnikova ,  Nikita Ilyich Ryzhikov ,  Dmitry Nikolaevich Mikhailov

IPC: G01N33/28 ,  G01N21/64 ,  G01N21/25

CPC classification number: G01N33/2823 ,  G01N21/253 ,  G01N21/64 ,  G01N21/91 ,  G01N21/94 ,  G01N2201/04

Abstract: A suspension of a contaminant comprising at least one solid component and colored with at least one cationic dye is prepared. The suspension is injected through a sample of the porous medium and the sample is then split. A distribution and a profile of the contaminant in the sample is determined on the basis of a distribution and an intensity of the at least one cationic dye.