公开(公告)号：US11754504B2

公开(公告)日：2023-09-12

申请号：US16648609

申请日：2018-09-19

Applicant: Beckman Coulter, Inc.

Inventor： Brian Kozicki ,  Creigh Thompson ,  Richard Wolf ,  Laura Holmes ,  David Sorrentino

IPC: G01N21/76 ,  G01N21/27 ,  G01J1/44

CPC classification number: G01N21/76 ,  G01J1/44 ,  G01N21/27 ,  G01N21/272 ,  G01J2001/444 ,  G01N2201/022 ,  G01N2201/12753

Abstract: Assays (100) may be performed with a luminometer (400) having a chassis (405) that may include a reaction vessel chamber (610). The luminometer (400) may also include a light passage (640) that intersects the reaction vessel chamber (610). The luminometer (400) may also include a cap (415) that, when in a closed configuration, prevents light emitted by external sources from entering the reaction vessel chamber (610) and from entering the light passage (640). The cap (415) may provide access to the reaction vessel chamber (610) when in an open configuration. The luminometer (400) may also include a calibration light source (460) optically coupled to one end of the light passage (640) and a light detector (630) optically coupled to another end of the light passage (640). The light detector (630) may include a sensing element for receiving light from the light passage (640).

公开(公告)号：US20230194433A1

公开(公告)日：2023-06-22

申请号：US18109980

申请日：2023-02-15

Applicant: Beckman Coulter, Inc.

Inventor： Richard Wolf ,  David Sorrentino ,  Takayuki Mizutani ,  Glenn Davis

IPC: G01N21/76 ,  G01N21/27 ,  G01J1/44

CPC classification number: G01N21/76 ,  G01N21/27 ,  G01J1/44 ,  G01N21/272 ,  G01N2201/022 ,  G01J2001/444 ,  G01N2201/12753

Abstract: A luminometer (400) includes a light detector (630) configured to sense photons (135). The luminometer (400) includes an analog circuit (915a) configured to provide an analog signal (965) based on the photons (135) emitted from assay reactions over a time period and a counter circuit (915b) configured to provide a photon count (970) based on the photons (135) emitted from the assay reactions over the time period. The luminometer (400) includes a luminometer controller (905) configured to, in response to an analog signal value of the analog signal (965) being greater than a predetermined value, determine and report a measurement value of the photons (135) emitted from the assay reactions over the time period based on the analog signal value of the analog signal (965) and a linear function (1010). Optionally, the linear function (1010) is derived from a relationship between the analog signal (965) and the photon count (970).

公开(公告)号：US20110054864A1

公开(公告)日：2011-03-03

申请号：US12914866

申请日：2010-10-28

Applicant: ALAN P. LUNDSTEDT ,  ALLEN L. HALL ,  CHING-HUI TSENG

Inventor： ALAN P. LUNDSTEDT ,  ALLEN L. HALL ,  CHING-HUI TSENG

IPC: G06F17/10

CPC classification number: G01N21/274 ,  G01N21/359 ,  G01N35/00712 ,  G01N35/00871 ,  G01N2035/00881 ,  G01N2201/12753 ,  G01N2201/12792

Abstract: A method of analysis, analysis system, program product, apparatus, and method of supplying analysis of value incorporating the use of at least one data acquisition device, a central processor, and a communication link that is connectable between the data acquisition device and the central processor. The central processor is loaded with multivariate calibration models developed for predicting values for various properties of interest, wherein the calibration models are capable of compensating for variations in an effectively comprehensive set of measurement conditions and secondary material characteristics. As so configured, the calibration models can compensate for instrument variance without instrument-specific calibration transfer. Measurement results generated by the central processor can be transmitted to an output device of a user interface.

Abstract translation: 一种分析，分析系统，程序产品，装置和提供分析价值的方法，该方法包括使用至少一个数据采集设备，中央处理器和通信链路，该数据采集设备和数据采集设备与中央 处理器。 中央处理器装载有用于预测感兴趣的各种性质的值的多变量校准模型，其中校准模型能够补偿有效全面的测量条件和次要材料特性的变化。 如此配置，校准模型可以补偿仪器差异，无需仪器特定的校准传输。 由中央处理器生成的测量结果可以被发送到用户界面的输出设备。

公开(公告)号：US20070143037A1

公开(公告)日：2007-06-21

申请号：US11707013

申请日：2007-02-15

Applicant: Alan Lundstedt ,  Allen Hall ,  Ching-Hui Tseng

Inventor： Alan Lundstedt ,  Allen Hall ,  Ching-Hui Tseng

IPC: G06F19/00

CPC classification number: G01N21/274 ,  G01N21/359 ,  G01N35/00712 ,  G01N35/00871 ,  G01N2035/00881 ,  G01N2201/12753 ,  G01N2201/12792

Abstract: The invention relates to providing analysis services to a plurality of customers using a plurality of data acquisition devices connected to a central processor, by way of a communication link, which is loaded with at least one calibration model configured to generate a predicted value of property of interest from data acquired from a pluraity of samples using the data acquisition devices wherein the analysis services include transmitting the predicted value of a property of interest to a customer from which analysis services is requested.

Abstract translation: 本发明涉及使用连接到中央处理器的多个数据采集装置，通过通信链路向多个客户提供分析服务，所述通信链路被加载有至少一个校准模型，所述至少一个校准模型被配置为生成预定的属性值 利用数据获取装置从样本采集获得的数据的兴趣，其中分析服务包括向请求分析服务的客户传送感兴趣的属性的预测值。

公开(公告)号：US20060152730A1

公开(公告)日：2006-07-13

申请号：US10538752

申请日：2003-09-24

Applicant: Reinhold Schneider

Inventor： Reinhold Schneider

IPC: G01N21/00

CPC classification number: G01N21/8507 ,  G01N15/06 ,  G01N21/274 ,  G01N21/31 ,  G01N21/534 ,  G01N2201/0228 ,  G01N2201/062 ,  G01N2201/12753 ,  G01N2201/12761 ,  G01N2201/128

Abstract: The invention relates to an optical sensor (1) for determining particle and/or dye concentrations in liquid or gaseous media and to a method for operating the same. The optical sensor (1) comprises at least one measuring head. The measuring head consists of an emitter unit (2) with a semiconductor emitting element (9), which emits visible emission light beams (8), and with a receiver unit (3) with a semiconductor receiving element (10). The portion of the emission light beams (8), which pass through an absorption section containing liquid or gaseous medium, is guided onto the receiving element (10). An evaluating unit (6) is coupled to the measuring head via electric leads (4, 4′), and the received signals, which are present at the output of the semiconductor receiving element (10), are evaluated inside said evaluating unit in order to determine the particle or die concentration.

Abstract translation: 本发明涉及一种用于确定液体或气体介质中的颗粒和/或染料浓度的光学传感器（1）及其操作方法。 光学传感器（1）包括至少一个测量头。 测量头由具有发射可见光发射光束（8）的半导体发射元件（9）的发射器单元（2）和具有半导体接收元件（10）的接收器单元（3）组成。 通过包含液体或气体介质的吸收部分的发射光束（8）的部分被引导到接收元件（10）上。 评估单元（6）经由电引线（4,4'）耦合到测量头，并且存在于半导体接收元件（10）的输出处的接收信号按照顺序在所述评估单元内进行评估 以确定颗粒或模具浓度。

公开(公告)号：US06741350B2

公开(公告)日：2004-05-25

申请号：US09858389

申请日：2001-05-16

Applicant: Hideyuki Ikeda ,  Seiichiro Yoshioka

Inventor： Hideyuki Ikeda ,  Seiichiro Yoshioka

IPC: G01N1502

CPC classification number: G01N15/02 ,  G01N15/1012 ,  G01N2201/12753

Abstract: This invention provides a particle size distribution measuring apparatus, which has a function of informing an operator of a procedure of validation work of the particle size distribution measuring apparatus. A storage medium which records validation data providing a procedure of validation work for the particle size distribution measuring apparatus and a control unit which has a validation help function which successively reads a validation procedure from the validation data and controls the particle size distribution measuring apparatus according to a measuring procedure without any operation by an operator in the validation procedure while teaching the operator a work procedure requiring an operation by the operator.

Abstract translation: 本发明提供了一种粒度分布测量装置，其具有向操作者通知粒度分布测量装置的验证工作程序的功能。 一种存储介质，其记录提供粒度分布测量装置的验证工作程序的验证数据和具有验证帮助功能的控制单元，该确认帮助功能从验证数据连续读取验证程序，并根据以下步骤控制粒度分布测量装置： 测量程序，无需操作人员在验证过程中的任何操作，同时向操作员讲授需要操作者进行操作的工作程序。

公开(公告)号：US20030135547A1

公开(公告)日：2003-07-17

申请号：US10188853

申请日：2002-07-05

Inventor： J. Thomas Kent ,  David A. Toot

IPC: G06F015/16

CPC classification number: G01N21/274 ,  G01N21/359 ,  G01N35/00712 ,  G01N35/00871 ,  G01N2035/00881 ,  G01N2201/12753 ,  G01N2201/12792

Abstract: An apparatus, program product and method incorporate an extensible modular communication executive for use integrating one or more electronic devices with one another with reduced customization overhead. A modular architecture is used to facilitate message-based communications in such a manner that queuing strategies, business rules and the like may be accommodated within a message-based environment in a reliable and efficient manner. Through the use of a modular architecture, application-specific software components can be assembled together to readily adapt a generic message-based system for use in a specific application. Moreover, intelligent pre-validation of messages may be implemented in such a modular architecture to permit a business rule-independent messaging infrastructure to be readily adapted to support specific business rule requirements for a particular application.

Abstract translation: 一种装置，程序产品和方法结合了可扩展的模块化通信执行器，用于将一个或多个电子设备彼此集成，并减少了定制开销。 模块化架构用于促进基于消息的通信，使得排队策略，业务规则等可以以可靠和有效的方式容纳在基于消息的环境中。 通过使用模块化架构，应用程序特定的软件组件可以组合在一起，以容易地适应用于特定应用的基于通用消息的系统。 此外，可以在这样的模块化架构中实现消息的智能预验证，以允许独立于业务规则的消息传递基础设施容易地适应于支持特定应用的特定业务规则要求。

公开(公告)号：US5247154A

公开(公告)日：1993-09-21

申请号：US642741

申请日：1991-01-17

Applicant: Hassan J. Ahmed

Inventor： Hassan J. Ahmed

IPC: G01N21/84 ,  G01N21/88 ,  G01N21/93 ,  G01N21/952 ,  G01N21/956 ,  G06K1/12 ,  G06K5/00 ,  G06K5/02 ,  G06K7/00

CPC classification number: G06K5/02 ,  G01N21/84 ,  G01N21/88 ,  G06K1/126 ,  G01N2021/95615 ,  G01N2201/12753

Abstract: A method and apparatus for monitoring the laser marking of a bar code label which has been laser marked onto the end of a nuclear fuel tube for unacceptable depth penetration of the heat affected zone. The average gray level value of the bar code label positioned on the end of the nuclear fuel tube is compared with a predetermined standard. In the method disclosed, a bar code label positioned on the surface of the nuclear fuel tube is optically sensed and a set of discrete digital values representative of the depth penetration of the heat affected zone is generated. The average digital value representative of the bar code label is calculated and the average digital value compared to a predetermined standard.

Abstract translation: 一种用于监测条形码标签的激光标记的方法和装置，其被激光标记在核燃料管的端部上，用于受热影响区的不可接受的深度穿透。 将位于核燃料管的末端的条形码标签的平均灰度值与预定标准进行比较。 在所公开的方法中，光学地检测位于核燃料管表面上的条形码标签，并且产生代表热影响区域的深度穿透的一组离散数字值。 计算代表条形码标签的平均数字值，并将平均数字值与预定标准进行比较。

公开(公告)号：US5067093A

公开(公告)日：1991-11-19

申请号：US469887

申请日：1990-01-24

Applicant: Catherine S. Przybylowicz ,  Edwin W. Brill, Jr. ,  Luigi A. Carrozziere

Inventor： Catherine S. Przybylowicz ,  Edwin W. Brill, Jr. ,  Luigi A. Carrozziere

IPC: G01N21/27 ,  G01N21/47 ,  G01N21/86

CPC classification number: G01N21/8483 ,  G01N2021/478 ,  G01N2201/12753 ,  G01N2201/128

Abstract: A method and apparatus are disclosed for reading a test element and a reference element in an incubator to insure that a) they are both read at the same wavelength and b) the reading at this wavelength of the reference element used to compare the test element reading, is the closest in point of time to the reading taken of the test element. In some cases, this requires the comparison with a reference element that is read after the reading of the test element.

Abstract translation: 公开了一种用于在培养箱中读取测试元件和参考元件以确保a）它们都以相同波长读取的方法和装置，以及b）用于比较测试元件读数的参考元件的该波长处的读数 是测试元素读取时间最接近的时间。 在某些情况下，这需要与读取测试元素后读取的参考元素进行比较。

公开(公告)号：US4939095A

公开(公告)日：1990-07-03

申请号：US370079

申请日：1989-06-22

Applicant: Noboru Yokotani

Inventor： Noboru Yokotani

IPC: G01N21/75 ,  G01N21/27 ,  G01N21/41 ,  G01N21/59 ,  G01N35/02 ,  G01N35/10

CPC classification number: G01N21/59 ,  G01N21/274 ,  G01N35/1002 ,  G01N2201/04 ,  G01N2201/12753 ,  Y10T436/113332

Abstract: An automatic chemical analyzer has a compensation coefficient calculating section and a light-path-length-based compensating section. The calculating section obtains the ratio of the absorbancies measured of reaction cells filled with a sample of the known absorbancy to the absorbancy measured of each cell, thereby calculating compensation coefficients for the respective cells. The compensating section multiplies the absorbancies measured of the cells refilled with samples of different unknown absorbancies by the compensation coefficients calculated by the calculating section, thereby compensating the absorbancies for the light path lengths of the cells. The compensated absorbancies, i.e., the absorbancies of the samples, are used in analyzing the samples.

Abstract translation: 自动化学分析仪具有补偿系数计算部和光路长度补偿部。 计算部分获得了填充有已知吸光度的样品的反应池的吸光度与每个单元的测量吸收度的比率，由此计算各个单元的补偿系数。 补偿部分将由不同未知吸收值的样品重新填充的单元的测量吸收值乘以由计算部分计算出的补偿系数，由此补偿单元的光路长度的吸收率。 补偿的吸收率，即样品的吸收率，用于分析样品。