公开(公告)号：US09696568B2

公开(公告)日：2017-07-04

申请号：US15153569

申请日：2016-05-12

Applicant: Lasertec Corporation

Inventor： Jun Sakuma

IPC: G02F1/11 ,  G02F1/35 ,  H01S3/00 ,  G02F1/355 ,  G02B27/14 ,  G01N21/95 ,  G01J1/04 ,  G01J3/12 ,  G01N21/17 ,  G01N21/63

CPC classification number: G02F1/113 ,  G01J1/0407 ,  G01J3/1256 ,  G01N21/1702 ,  G01N21/636 ,  G01N21/9501 ,  G01N2201/06113 ,  G01N2201/068 ,  G02B27/141 ,  G02F1/116 ,  G02F1/3534 ,  G02F1/3551 ,  H01S3/005 ,  H01S3/0085 ,  H01S3/0092 ,  H01S3/1306 ,  H01S3/2391

Abstract: Provided are a light source apparatus and an inspection apparatus that can stably output a wavelength converted light beam. A light source apparatus includes a laser light source that generates a first fundamental light beam, at least one nonlinear optical crystal that generates a wavelength converted light beam using the fundamental light beam or a harmonic laser beam of the fundamental light beam as an incident light beam, a detector that detects the wavelength converted light beam, an acousto-optic modulator that is disposed in an optical path of the incident light beam in such a way that a zero-order light beam enters the nonlinear optical crystal, and a controller that controls an output intensity of the wavelength converted light beam according to a detection signal from the detector.

公开(公告)号：US09683938B2

公开(公告)日：2017-06-20

申请号：US14906789

申请日：2014-06-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Zoltan Gorocs ,  Yuye Ling ,  Meng Dai Yu

IPC: G02B26/08 ,  G01N21/64 ,  G01N33/50 ,  G01N15/14 ,  G01N33/58

CPC classification number: G01N21/6458 ,  G01N15/1434 ,  G01N15/1456 ,  G01N21/6456 ,  G01N33/50 ,  G01N33/582 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/101

Abstract: A scanning system for fluorescent imaging includes a sample holder configured to hold a sample therein, the sample holder defining a sample holding region. A scanner head spans the sample holding region and is movable relative to the sample holder. An array of light sources is disposed on an opposing side of the sample holder and is angled relative thereto. Respective controller are operably coupled to the scanner head and the array of light sources, wherein one controller selectively actuates a one or more rows of the array of light sources and another controller controls movement of the scanner head to capture fluorescent light emitted from within the sample holder in response to illumination from the actuated light sources. A filter designed to filter out scattered light from the sample may be interposed between the sample holder and the scanner head.

公开(公告)号：US09675288B2

公开(公告)日：2017-06-13

申请号：US14764528

申请日：2013-01-29

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Mineo Yamakawa ,  Zhiyong Li

IPC: B01L3/00 ,  A61B5/1459 ,  G01N21/65 ,  A61B5/00 ,  G01N21/25

CPC classification number: A61B5/1459 ,  A61B5/6848 ,  A61B2562/0238 ,  A61B2562/12 ,  G01N21/658 ,  G01N2021/258 ,  G01N2201/061 ,  G01N2201/068

Abstract: According to an example, an apparatus for performing spectroscopy includes an elongated substrate having a shape and size to be inserted into a specimen, wherein the elongated substrate has a first end and a second end. The apparatus also includes a plurality of surface-enhanced spectroscopy (SES) elements positioned on an exterior surface of the elongated substrate at a location between the first end and the second end of the elongated substrate.

公开(公告)号：US09651552B2

公开(公告)日：2017-05-16

申请号：US14810530

申请日：2015-07-28

Applicant: Autoimmun Diagnostika GmbH

Inventor： Volkmar Schöllhorn

IPC: A61K39/04 ,  A61K39/02 ,  G01N33/53 ,  G01N33/569 ,  G01N21/64 ,  G01N33/50

CPC classification number: G01N33/56972 ,  G01N21/6428 ,  G01N33/50 ,  G01N33/5091 ,  G01N33/53 ,  G01N33/569 ,  G01N2021/6439 ,  G01N2201/068 ,  G01N2333/55 ,  G01N2333/57 ,  G01N2800/26 ,  G01N2800/52

Abstract: An ELISPOT method of in vitro diagnosis of tuberculosis includes enriching or separating liquid blood fraction from its cellular components including visualizing immunocompetent cells by detecting different dyes and using at least two different filter sets, each including one narrowband excitation filter and one narrowband blocking filter, wherein the narrowband excitation filter is transmissive for light provided for luminescent excitation of a respective dye and the narrowband blocking filter is transmissive for light emitted by a respective dye and measuring the number of immunocompetent cells that secrete at least interferon-γ and interleukin-2 as a reaction to an antigen by superimposing at least two two-dimensional images generated during visualization to avoid luminescence of different dyes interfering and strong luminescence being superimposed on weak luminescence.

公开(公告)号：US20170122864A1

公开(公告)日：2017-05-04

申请号：US15299780

申请日：2016-10-21

Applicant: Seiko Epson Corporation

Inventor： Tsugio GOMI

IPC: G01N21/25 ,  B41J29/38 ,  G01N21/27

CPC classification number: G01N21/251 ,  B41J11/0095 ,  B41J29/38 ,  G01J3/0289 ,  G01J3/26 ,  G01J3/46 ,  G01J3/50 ,  G01N21/27 ,  G01N21/31 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0633 ,  G01N2201/068

Abstract: A spectrometer includes a light source that radiates illumination light, and a measurement unit that measures measurement light in which illumination light is reflected by a medium. In a case where an illumination region that is a region in which the medium is irradiated with illumination light is smaller than a measurement region that is a region of the medium measurable by the measurement unit and in which the movement of the medium in the direction is within a range of an acceptable fluctuation amount, the illumination region is included in the measurement region.

公开(公告)号：US20170115207A1

公开(公告)日：2017-04-27

申请号：US15400554

申请日：2017-01-06

Applicant: Honeywell International Inc.

Inventor： Wei Yang ,  Teresa M. Marta ,  Martin Willett ,  Rodney R. Watts

IPC: G01N21/17 ,  G01N33/00 ,  G01N21/61

CPC classification number: G01N21/1702 ,  G01J5/02 ,  G01J5/42 ,  G01N21/61 ,  G01N33/0027 ,  G01N2021/1704 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/12

Abstract: Gas detector devices, systems, and methods using a Golay cell are described herein. One device includes a microphone having a front surface with an sound collecting aperture for receiving sound, a substrate, a gas cavity formed in the substrate such that the gas cavity is in gas communication with the sound collecting aperture and the front surface forms a side surface of the gas cavity, and a window abutting the substrate to form a side surface of the gas cavity.

公开(公告)号：US09594005B2

公开(公告)日：2017-03-14

申请号：US14754618

申请日：2015-06-29

Applicant: Pulse Health LLC

Inventor： David Barsic ,  Rachel Dreilinger ,  Martin Krauss ,  Jon Boro ,  James Ingle

IPC: G01N21/64 ,  G01N21/63 ,  G01N33/52 ,  G01N33/50 ,  G01N1/22 ,  G01N33/497 ,  G01D11/24

CPC classification number: G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

Abstract: A fluorescence detection assembly that includes an emitter, a detector, a housing that defines an light chamber, a fluorescence chamber and a well, a light path that extends from the emitter, through the light chamber and through the well, and a fluorescence path that extends from the well, through the fluorescence chamber and to the detector.

Abstract translation: 一种荧光检测组件，其包括发射器，检测器，限定光室的壳体，荧光腔和阱，从发射器延伸穿过光室并通过阱的光路，以及荧光路径， 从孔延伸通过荧光室和检测器。

公开(公告)号：US20170052112A1

公开(公告)日：2017-02-23

申请号：US15344704

申请日：2016-11-07

Applicant: KLA-Tencor Corporation

Inventor： Lawrence Rotter ,  Klaus Flock ,  Muzammil Arain ,  David Y. Wang

IPC: G01N21/23 ,  G01N21/21 ,  G01N21/95 ,  G02B5/30

CPC classification number: G01N21/23 ,  G01N21/211 ,  G01N21/9501 ,  G01N2021/213 ,  G01N2201/068 ,  G02B5/3083 ,  G02B5/3091 ,  G02F1/13363

Abstract: A rotatable compensator configured to transmit non-collimated light over a broad range of wavelengths, including ultraviolet, with a high degree of retardation uniformity across the aperture is presented. In one embodiment, a rotatable compensator includes a stack of four individual plates in optical contact. The two thin plates in the middle of the stack are made from a birefringent material and are arranged to form a compound, zeroth order bi-plate. The remaining two plates are relatively thick and are made from an optically isotropic material. These plates are disposed on either end of the compound, zeroth order bi-plate. The low order plates minimize the sensitivity of retardation across the aperture to non-collimated light. Materials are selected to ensure transmission of ultraviolet light. The optically isotropic end plates minimize coherence effects induced at the optical interfaces of the thin plates.

Abstract translation: 提供了一种可旋转补偿器，其被配置为在宽范围的波长（包括紫外线）上传输非准直光，并且在整个孔径上具有高程度的延迟均匀性。 在一个实施例中，可旋转补偿器包括光学接触的四个单独板的堆叠。 堆叠中间的两个薄板由双折射材料制成并且被布置成形成复合物，零级双板。 剩余的两个板相对较厚并且由光学各向同性材料制成。 这些板设置在化合物的任一端，为零级双板。 低阶平板将通过光圈的延迟的灵敏度最小化为非准直光。 选择材料以确保紫外线的透射。 光学各向同性的端板最小化在薄板的光学界面处引起的相干效应。

公开(公告)号：US09575005B2

公开(公告)日：2017-02-21

申请号：US15033367

申请日：2014-11-03

Applicant: TOMRA SORTING NV

Inventor： Dirk Balthasar ,  Hartmut Harbeck

IPC: G01N21/00 ,  G01N21/85 ,  B07C5/342

CPC classification number: G01N21/85 ,  B07C5/342 ,  G01N2201/06113 ,  G01N2201/06193 ,  G01N2201/062 ,  G01N2201/0636 ,  G01N2201/068

Abstract: An apparatus for inspecting a stream of matter including: a first and a second light source for emitting a first and a second light beam; a first and a second detector; a first scanning element adapted to redirect the detection area of the second detector from side to side across said stream, and a beam splitting element arranged to receive said first and second light beams, after they have been reflected against said matter, wherein said beam splitting element is adapted to guide said reflected first light beam towards said first detector and to guide said reflected second light beam towards said second detector.

Abstract translation: 一种用于检查物流的装置，包括：用于发射第一和第二光束的第一和第二光源; 第一和第二检测器; 第一扫描元件，其适于将所述第二检测器的检测区域从所述流的一侧到另一侧重定向;以及分束元件，其布置成在它们已经被反射抵靠所述物质之后接收所述第一和第二光束，其中所述光束分裂 元件适于将所述反射的第一光束引向所述第一检测器并且将所述反射的第二光束引导到所述第二检测器。

公开(公告)号：US09574990B2

公开(公告)日：2017-02-21

申请号：US14377708

申请日：2012-02-28

Applicant: Devin Alexander Mourey ,  Vladek Kasperchik ,  James William Stasiak

Inventor： Devin Alexander Mourey ,  Vladek Kasperchik ,  James William Stasiak

IPC: G01N21/65 ,  G01N21/01

CPC classification number: G01N21/01 ,  G01N21/658 ,  G01N2201/02 ,  G01N2201/068

Abstract: The present disclosure describes a surface enhanced Raman spectroscopy (SERS) apparatus and methods of forming and using the SERS apparatus. An example of a SERS apparatus includes a nanoporous material on an upper surface of a substrate, a plurality of SERS-active structures on an upper surface of the nanoporous material, and a Raman-active material on a surface of each of SERS-active structures.

Abstract translation: 本公开描述了表面增强拉曼光谱（SERS）装置以及形成和使用SERS装置的方法。 SERS装置的实例包括在基底的上表面上的纳米多孔材料，在纳米多孔材料的上表面上的多个SERS-活性结构，以及每个SERS活性结构的表面上的拉曼活性物质 。