公开(公告)号：US20180284017A1

公开(公告)日：2018-10-04

申请号：US15471852

申请日：2017-03-28

Applicant: TE Connectivity Corporation

Inventor： Soren Grinderslev ,  Igor Stouklov ,  Mark Benton

IPC: G01N21/41 ,  G01N21/94

CPC classification number: G01N21/4133 ,  G01F23/00 ,  G01N21/552 ,  G01N21/94 ,  G01N2021/945 ,  G01N2201/0826

Abstract: A sensor for detecting the level of accumulation of a material along an axis in a fluid environment, the sensor comprising (a) an optically transparent body having a third refractive index and an exposed surface defining a length extending at least partially in the direction of the axis; (b) at least one light delivery source for delivering light to the body such that the light is distributed along the length of the exposed surface; and at least one light receiver for receiving reflected light from the length of the exposed surface, wherein the amount of the reflected light depends on the level of the material accumulated along the length of the exposed surface

公开(公告)号：US20180223335A1

公开(公告)日：2018-08-09

申请号：US15941383

申请日：2018-03-30

Applicant: Streck, Inc.

Inventor： Matthew R. Kreifels ,  Scott E. Whitney ,  Joel R. TerMaat

IPC: C12Q1/686 ,  G01N21/64

CPC classification number: C12Q1/686 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate reduced sample read time and rapid reading of multiple light wavelengths.

公开(公告)号：US20180217048A1

公开(公告)日：2018-08-02

申请号：US15853022

申请日：2017-12-22

Applicant: TRUSTEES OF TUFTS COLLEGE

Inventor： DAVID R. WALT ,  KARRI LYNN MICHAEL-BALLARD

IPC: G01N15/14 ,  C12Q1/6837 ,  B01J19/00 ,  G01N33/543

CPC classification number: G01N15/1456 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B82Y30/00 ,  C12Q1/6837 ,  C40B40/06 ,  C40B40/10 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/7703 ,  G01N21/78 ,  G01N33/543 ,  G01N33/54313 ,  G01N2015/1438 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2035/0097 ,  G01N2201/0826 ,  Y02A50/55 ,  Y10S435/808 ,  Y10S436/805

Abstract: A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. A wide variety of modified substrates may be employed which provide either discrete or non-discrete sites for accommodating the microspheres in either random or patterned distributions. The substrates may be constructed from a variety of materials to form either two-dimensional or three-dimensional configurations. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents.

公开(公告)号：US09958325B2

公开(公告)日：2018-05-01

申请号：US15624008

申请日：2017-06-15

Applicant: Metal Power Analytical (I) Pvt. Ltd.

Inventor： Priyadarshan Divyadarshan Pant

IPC: G01J3/28 ,  G01J3/06 ,  G01J3/02 ,  G01J3/04 ,  G01J3/443 ,  G01N21/31 ,  G01N21/33 ,  G01J3/18 ,  G01J3/32

CPC classification number: G01J3/06 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/04 ,  G01J3/18 ,  G01J3/2803 ,  G01J3/32 ,  G01J3/443 ,  G01J2003/045 ,  G01J2003/061 ,  G01J2003/065 ,  G01J2003/282 ,  G01N21/3103 ,  G01N21/33 ,  G01N2201/0826

Abstract: The present disclosure relates to the field of optical systems. The envisaged multi-scan optical system is compact and stable. The system comprises an excitation source, a hydra fiber cable, a wavelength selector, an optical element, and a detector. The excitation source is configured to emit composite light. The hydra fiber cable has a head and a plurality of tentacles, and is configured to receive the composite light via a second lens. The plurality of tentacles is configured to emit the composite light towards the wavelength selector which includes a plurality of optical slits (s1-s8) and a plurality of shutters. The wavelength selector is configured to selectively collect and filter the composite light directed by a first lens and the plurality of tentacles by means of the plurality of shutters. The detector is configured to detect the plurality of spectral line scans reflected by the optical element for spectrometric analysis.

公开(公告)号：US09932632B2

公开(公告)日：2018-04-03

申请号：US13833349

申请日：2013-03-15

Applicant: Streck, Inc.

Inventor： Matthew R. Kreifels ,  Scott E. Whitney ,  Joel R. TerMaat

IPC: G01N21/00 ,  C12Q1/68 ,  G01N21/64

CPC classification number: C12Q1/686 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate reduced sample read time and rapid reading of multiple light wavelengths.

公开(公告)号：US20170248576A1

公开(公告)日：2017-08-31

申请号：US15441401

申请日：2017-02-24

Applicant: SYSMEX CORPORATION

Inventor： Naoto Nishimura ,  Tsuyoshi Fukuzaki

IPC: G01N33/49 ,  G01N21/13 ,  G01N21/27 ,  G01N15/06 ,  G01N21/25

CPC classification number: G01N33/4905 ,  G01N15/06 ,  G01N21/13 ,  G01N21/255 ,  G01N21/27 ,  G01N21/272 ,  G01N21/274 ,  G01N21/314 ,  G01N21/3151 ,  G01N21/59 ,  G01N21/77 ,  G01N21/78 ,  G01N33/492 ,  G01N33/86 ,  G01N2015/0693 ,  G01N2021/135 ,  G01N2021/3148 ,  G01N2021/3181 ,  G01N2021/3188 ,  G01N2021/7783 ,  G01N2201/06153 ,  G01N2201/0631 ,  G01N2201/0826 ,  G02B6/00 ,  G02B6/0008 ,  G02B6/4204 ,  G02B6/4228

Abstract: A blood coagulation analyzer comprises: a light irradiation unit configured to apply light onto a container configured to store a measurement specimen containing a sample and a reagent, and comprising: light sources including a first light source configured to generate light of a first wavelength for blood coagulation time measurement, a second light source configured to generate light of a second wavelength for synthetic substrate measurement, and a third light source configured to generate light of a third wavelength for immunonephelometry measurement; and optical fiber parts facing the respective light sources; a light reception part configured to receive light transmitted through the container; and an analysis unit configured to analyze the sample using an electric signal outputted from the light reception part.

公开(公告)号：US20170216846A1

公开(公告)日：2017-08-03

申请号：US15429765

申请日：2017-02-10

Applicant: STOKES BIO LIMITED

Inventor： Mark DAVIES ,  Tara DALTON

IPC: B01L7/00 ,  C12Q1/68 ,  B01L3/00

CPC classification number: B01L7/525 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/185 ,  B01L2400/0487 ,  C12Q1/686 ,  G01N21/6428 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A thermal cycling device comprising a number of fixed thermal zones and a fixed conduit passing through the thermal zones. A controller maintains each thermal zone including its section of conduit at a constant temperature. A series of droplets flows through the conduit so that each droplet is thermally cycled, and a detection system detects fluorescence from droplets at all of the thermal cycles. The conduit is in a single plane, and so a number of thermal cycling devices may be arranged together to achieve parallelism. The flow conduit comprises a channel and a capillary tube inserted into the channel. The detection system may perform scans along a direction to detect radiation from a plurality of cycles in a pass.

公开(公告)号：US09714899B2

公开(公告)日：2017-07-25

申请号：US15027179

申请日：2014-11-18

Applicant: versalis S.p.A.

Inventor： Francesco Bonacini ,  Erik Mantovani ,  Angelo Ferrando

IPC: C08F2/00 ,  C08F4/00 ,  C08F12/02 ,  G01N21/27 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/85 ,  C08F112/08

CPC classification number: G01N21/272 ,  C08F112/08 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/8507 ,  G01N2201/061 ,  G01N2201/0826 ,  G01N2201/13

Abstract: The present invention relates to a method for monitoring a control parameter of a polymerization reaction mixture in heterogeneous phase comprising the following steps: (a) acquiring at least one NIR reflectance spectrum of said mixture; (b) calculating a value of said control parameter by means of a calibration curve which correlates the NIR reflectance spectrum with the values of said control parameter measured with a reference measurement method. The present invention also relates to an apparatus for implementing said method.

公开(公告)号：US20170184578A1

公开(公告)日：2017-06-29

申请号：US15457728

申请日：2017-03-13

Applicant: TRUSTEES OF TUFTS COLLEGE

Inventor： DAVID R. WALT ,  KARRI LYNN MICHAEL-BALLARD

IPC: G01N33/543 ,  G01N21/77 ,  G01N21/64 ,  G01N21/78

CPC classification number: G01N15/1456 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B82Y30/00 ,  C12Q1/6837 ,  C40B40/06 ,  C40B40/10 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/7703 ,  G01N21/78 ,  G01N33/543 ,  G01N33/54313 ,  G01N2015/1438 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2035/0097 ,  G01N2201/0826 ,  Y02A50/55 ,  Y10S435/808 ,  Y10S436/805

Abstract: A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. A wide variety of modified substrates may be employed which provide either discrete or non-discrete sites for accommodating the microspheres in either random or patterned distributions. The substrates may be constructed from a variety of materials to form either two-dimensional or three-dimensional configurations. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents.

公开(公告)号：US09488574B2

公开(公告)日：2016-11-08

申请号：US12682939

申请日：2008-10-13

Applicant: Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

Inventor： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC: G01N21/47 ,  A61B5/00 ,  G01N21/17

CPC classification number: G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

Abstract translation: 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。