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    Conjugate for treating malaria
    61.
    发明授权
    Conjugate for treating malaria 有权

    公开(公告)号：US10479854B2

    公开(公告)日：2019-11-19

    申请号：US15503175

    申请日：2015-08-12

    Applicant: Stellenbosch University

    Inventor： Lubertus Klumperman ,  Paul William Reader ,  Marina Rautenbach

    IPC: A61K38/08 ,  C08F226/10

    Abstract: A peptide-polymer conjugate is provided for use in treating malaria infections, and in particular terminal or drug resistant malaria infections. The conjugate is formed from a polymer to which a peptide having activity against a malaria parasite is co-valently attached. The peptide is a cyclic decapeptide from the closely-related group of tyrocidines, tryptocidines, phenycidines and gramicidin S, and the polymer is a hydrophilic and biocompatible polymer with a terminal thiol, such as poly(N-vinylpyrrolidone) (PVP). The polymer chains can be decorated with a hydrophilic targeting ligand that specifically targets an epitope on red blood cells, and in particular red blood cells infected with a plasmodial parasite. A method for synthesising the peptide-polymer conjugate is also provided.

    METHOD OF DETERMINING AUTOPHAGOSOME FLUX AND USES THEREOF
    63.
    发明申请
    METHOD OF DETERMINING AUTOPHAGOSOME FLUX AND USES THEREOF 审中-公开

    公开(公告)号：US20190113525A1

    公开(公告)日：2019-04-18

    申请号：US16099831

    申请日：2017-05-10

    Applicant: Stellenbosch University

    Inventor： Benjamin Loos ,  Andre Du Toit ,  Jan Hendrik Servaas Hofmeyr

    IPC: G01N33/68

    Abstract: A method for measuring autophagosome flux is provided. The autophagosome pool size in a single cell is quantified, where the pool size is the total number of autophagosomes in the cell. Fusion between the autophagosomes and lysosomes in the cell is then inhibited. The autophagosome pool size is quantified over one or more time points after fusion has been inhibited, and the autophagosome flux is calculated as the initial rate of change of the autophagosome pool size at the time point after fusion has been inhibited. The method can be used to determine basal autophagosome flux, whether a cell is diseased or dysfunctional, or to diagnose a subject with a disease, disorder or dysfunction. The transition time, the time required to clear an autophagosome pool, can also be derived from the autophagosome flux. A molecule can also be characterized according to its ability to modulate autophagosome flux in a cell.

    Method and system for determining fluid density
    64.
    发明授权
    Method and system for determining fluid density 有权

    公开(公告)号：US09933347B2

    公开(公告)日：2018-04-03

    申请号：US15511121

    申请日：2015-09-15

    Applicant: Stellenbosch University

    Inventor： Cornelius Louwrens Pieterse

    IPC: H01J49/00 ,  G01N9/24 ,  G01N27/00 ,  B05B5/025

    CPC classification number: G01N9/24 ,  B05B5/0255 ,  G01N9/00 ,  G01N27/002

    Abstract: A method and system for determining a density of a fluid is provided. The method is carried out using an electrospraying apparatus connected in the system. At a first step fluid is introduced into an emitter of the electrospraying apparatus. A voltage is applied between the emitter and a counter-electrode spaced apart from the emitter for a number of intermittent time periods, wherein the duration of at least some of the time periods during which the voltage is applied progressively decreases. The current between the emitter and the counter-electrode is measured for each time period during which a voltage is applied and the shortest time period for which a current reading is obtained is recorded. The shortest time period is used to calculate the density of the fluid in the emitter.

    IMAGING PHANTOM FOR RADIATION BASED EQUIPMENT
    65.
    发明申请
    IMAGING PHANTOM FOR RADIATION BASED EQUIPMENT 审中-公开

    公开(公告)号：US20180047303A1

    公开(公告)日：2018-02-15

    申请号：US15555932

    申请日：2016-03-02

    Applicant: Stellenbosch University

    Inventor： Annemari Groenewald

    IPC: G09B23/28 ,  A61B6/00

    CPC classification number: G09B23/286 ,  A61B6/03 ,  A61B6/502 ,  A61B6/583 ,  G06T2207/30168

    Abstract: A versatile phantom provides image quality control on multiple different types of medical x-ray imaging equipment. The phantom has a radiolucent housing including a first series of elements of the same shape and size wherein each element has a different electron density such that grey scale can be evaluated. A second series of elements of the same shape and material has a range of different sizes for assessing low contrast detectability. At least one position indicating item is selected from a central ball within the housing, position indicating lines on the housing and a unique flat peripheral face of the housing. The phantom also has at least one mammography dedicated item selected from elements representative of mammography fibres and mammography micro-calcifications. An instruction manual and optional result analysis program provides for semi-automatic result analysis for analyzing results and recommending corrective action for test results that are out of tolerance.

    ANKLE IMAGING ACCESSORY
    66.
    发明申请
    ANKLE IMAGING ACCESSORY 审中-公开

    公开(公告)号：US20170347977A1

    公开(公告)日：2017-12-07

    申请号：US15609359

    申请日：2017-05-31

    Applicant: Stellenbosch University

    Inventor： De la Rey Hertzog Scheepers Badenhorst

    IPC: A61B6/04 ,  A61B6/00

    CPC classification number: A61B6/505 ,  A61B6/0421 ,  A61B6/582

    Abstract: An ankle imaging accessory is provided by the present invention, particularly an ankle positioning device to facilitate the taking of X-ray views of a patient who had sustained an ankle fracture. The ankle imaging accessory is made from an X-ray translucent material and includes heel supports on which heels of a patient can locate. A pair of spaced apart stops defines the limits of an arc on which a foot pivoting on the heel support can move.

    THERMAL ENERGY STORAGE FACILITY
    70.
    发明申请
    THERMAL ENERGY STORAGE FACILITY 审中-公开

    公开(公告)号：US20170082380A1

    公开(公告)日：2017-03-23

    申请号：US15311774

    申请日：2015-05-12

    Applicant: Stellenbosch University

    Inventor： Paul Gauché ,  André du Randt Louw

    IPC: F28D20/00 ,  F28F21/08 ,  F28F21/04

    CPC classification number: F28D20/0056 ,  F28F21/04 ,  F28F21/08 ,  F28F2265/26 ,  Y02E60/142

    Abstract: A thermal energy storage facility is provided that consists of a packed bed with an essentially unconstrained outer region and a duct having a heat exchange end region located within a central lower region of the packed bed and a fluid supply end opposite the heat exchange end region. The heat exchange end region of the duct permits heat transfer fluid at an elevated temperature to pass from the duct to the packed bed during a charge cycle to heat the packed bed from an inner region outwards. The heat transfer fluid is drawn from the packed bed into the duct during a discharge cycle.

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