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    MULTIPLEXED SHRNAS AND USES THEREOF
    64.
    发明申请
    MULTIPLEXED SHRNAS AND USES THEREOF 审中-公开

    公开(公告)号：US20170240899A1

    公开(公告)日：2017-08-24

    申请号：US15519359

    申请日：2015-10-14

    Applicant: Texas Tech University System

    Inventor： Haoquan WU ,  Jang-gi CHOI

    IPC: C12N15/113 ,  A61K48/00

    CPC classification number: C12N15/1132 ,  A61K48/005 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/31 ,  C12N2310/3519 ,  C12N2310/51 ,  C12N2310/531 ,  C12N2330/51 ,  C12N2740/15042 ,  C12N2750/14142

    Abstract: Nucleic acid molecules such as shRNA clusters and artificial miRNA clusters are disclosed, Also disclosed are methods of use, compositions, cells, viral particles, and kits relating to the nucleic acid molecules disclosed herein. The disclosure provides, at least in part nucleic acid molecules such as shRNA clusters encoding shRNA-like molecules and artificial miRNA clusters encoding modified pri-miRNA-like molecules. The shRNA clusters and artificial miRNA clusters disclosed herein can be used, for example, to produce artificial RNA molecules, e.g., RNAi molecules. Cells, viral particles, compositions (e.g., pharmaceutical compositions), kits, and methods relating to the nucleic acid molecules, e.g., shRNA clusters and artificial miRNA clusters, are also disclosed. The nucleic acid molecules (e.g., shRNA clusters and artificial miRNA clusters), artificial RNA molecules (e.g., RNAi molecules), cells, viral particles, compositions (e.g., pharmaceutical compositions), and kits and methods disclosed herein can be used to treat or prevent a disease, e.g., HIV infection and/or AIDS.

    System and method for evaluating wind flow fields using remote sensing devices
    65.
    发明授权
    System and method for evaluating wind flow fields using remote sensing devices 有权
    使用遥感装置评估风流场的系统和方法

    公开(公告)号：US09519056B2

    公开(公告)日：2016-12-13

    申请号：US13952606

    申请日：2013-07-27

    Applicant: Texas Tech University System

    Inventor： John Schroeder ,  Brian Hirth ,  Jerry Guynes

    IPC: G01S13/95 ,  G01P5/00 ,  G01S13/87 ,  G01S13/58

    CPC classification number: G01S13/95 ,  F03D17/00 ,  F05B2270/32 ,  F05B2270/321 ,  G01P5/001 ,  G01S13/589 ,  G01S13/87 ,  G01S13/951 ,  G01S13/956 ,  Y02A90/18

    Abstract: The present invention provides a system and method for obtaining data to determine one or more characteristics of a wind field using a first remote sensing device and a second remote sensing device. Coordinated data is collected from the first and second remote sensing devices and analyzed to determine the one or more characteristics of the wind field. The first remote sensing device is positioned to have a portion of the wind field within a first scanning sector of the first remote sensing device. The second remote sensing device is positioned to have the portion of the wind field disposed within a second scanning sector of the second remote sensing device.

    Abstract translation: 本发明提供一种用于使用第一遥感装置和第二遥感装置获得数据以确定风场的一个或多个特性的系统和方法。 协调数据从第一和第二遥感装置收集并分析以确定风场的一个或多个特征。 第一遥感装置被定位成将风场的一部分置于第一遥感装置的第一扫描扇区内。 第二遥感装置被定位成使风场的部分设置在第二遥感装置的第二扫描扇区内。

    SYSTEM AND METHOD FOR CHEMICALLY PATTERNED PAPER MICROFLUIDIC DEVICES
    67.
    发明申请
    SYSTEM AND METHOD FOR CHEMICALLY PATTERNED PAPER MICROFLUIDIC DEVICES 审中-公开
    用于化学图案微流体装置的系统和方法

    公开(公告)号：US20160339428A1

    公开(公告)日：2016-11-24

    申请号：US15135326

    申请日：2016-04-21

    Applicant: Texas Tech University System

    Inventor： Jungkyu Kim ,  Ryan Howse

    IPC: B01L3/00 ,  C23C16/04 ,  C23C16/30

    CPC classification number: B01L3/502707 ,  B01L3/50273 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/126 ,  B01L2400/0406 ,  C23C16/04

    Abstract: Disclosed is a device and method for forming a chemically patterned paper microfluidic device (cPMD) having controllable hydrophobic regions for purposes of providing a repeatable and versatile production with no temperature limitations similar or expensive printers, enabling point of care sensor devices. The disclosed invention comprises multilayer capability, including the ability for various biomolecules to be immobilized with charge interaction. The paper-based microfluidic platform as disclosed repeatable, versatile, cost effective, and allows for the creation of complex channels using the settling time calculated from calibration results. The disclosed system supports a wide variety of scenarios for testing, diagnostics and drug delivery, and related products and services.

    Abstract translation: 公开了一种用于形成具有可控疏水区域的化学图案化纸微流体装置（cPMD）的装置和方法，用于提供无可重复和多功能的生产，没有类似或昂贵的打印机的温度限制，使得护理点传感器装置。 所公开的发明包括多层能力，包括各种生物分子用电荷相互作用固定的能力。 所公开的基于纸张的微流体平台可重复，通用，成本有效，并允许使用由校准结果计算的建立时间来创建复杂通道。 所公开的系统支持用于测试，诊断和药物递送以及相关产品和服务的各种场景。

    MICROWAVE-INDUCED LOCALIZED HEATING OF CNT FILLED POLYMER COMPOSITES FOR ENHANCED INTER-BEAD DIFFUSIVE BONDING OF FUSED FILAMENT FABRICATED PARTS
    68.
    发明申请
    MICROWAVE-INDUCED LOCALIZED HEATING OF CNT FILLED POLYMER COMPOSITES FOR ENHANCED INTER-BEAD DIFFUSIVE BONDING OF FUSED FILAMENT FABRICATED PARTS 审中-公开
    微波诱导的CNT填充聚合物复合材料的局部加热，用于增强熔融纤维织物的增强肋间连接

    公开(公告)号：US20160325491A1

    公开(公告)日：2016-11-10

    申请号：US15108217

    申请日：2014-12-26

    Applicant: TEXAS TECH UNIVERSITY SYSTEM

    Inventor： Charles B. Sweeney ,  Micah J. Green ,  Mohammad Saed

    IPC: B29C67/00 ,  B29B15/14 ,  B33Y80/00 ,  B33Y30/00 ,  B33Y70/00 ,  B29C35/08 ,  B33Y10/00

    Abstract: A microwave-induced heating of CNT filled (or coated) polymer composites for enhancing inter-bead diffusive bonding of fused filament fabricated parts. The technique incorporates microwave absorbing nanomaterials (carbon nanotubes (CNTs)) onto the surface or throughout the volume of 3D printer polymer filament to increase the inter-bead bond strength following a post microwave irradiation treatment and/or in-situ focused microwave beam during printing. The overall strength of the final 3D printed part will be dramatically increased and the isotropic mechanical properties of fused filament part will approach or exceed conventionally manufactured counterparts.

    Abstract translation: CNT填充（或涂覆）聚合物复合材料的微波诱导加热，用于增强熔丝长丝制造部件的珠间扩散接合。 该技术将微波吸收纳米材料（碳纳米管（CNTs））纳入到3D打印机聚合物长丝的表面或整个体积上，以在印刷后的微波辐射处理和/或原位聚焦微波束之后增加珠间粘合强度 。 最终3D印刷部件的总体强度将显着增加，并且熔丝部分的各向同性力学性能将接近或超过常规制造的对应物。

    Identification and quantification of intact glycopeptides in complex samples
    69.
    发明授权
    Identification and quantification of intact glycopeptides in complex samples 有权
    复杂样品中完整糖肽的鉴定和定量

    公开(公告)号：US09459258B2

    公开(公告)日：2016-10-04

    申请号：US14402686

    申请日：2013-05-21

    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION ,  TEXAS TECH UNIVERSITY SYSTEM

    Inventor： Haixu Tang ,  Yehia S. Mechref

    IPC: G06G7/58 ,  G01N33/68 ,  C12Q1/37 ,  G06F19/00 ,  G01N33/48

    CPC classification number: G01N33/6848 ,  C12Q1/37 ,  G01N33/6842 ,  G01N2440/38 ,  G06F19/70

    Abstract: Illustrative embodiments of methods and apparatus for identifying one or more intact glycopeptides in a sample are disclosed. According to one illustrative embodiment, a method may comprise receiving data representing a plurality of mass spectra obtained from mass spectrometry of the sample, scoring data representing each of the plurality of mass spectra against data associated with target glycopeptides, and identifying one or more intact glycopeptides in the sample based at least in part on the scoring of the data representing each of the plurality of mass spectra.

    Abstract translation: 公开了用于鉴定样品中一种或多种完整糖肽的方法和装置的说明性实施方案。 根据一个说明性实施例，方法可以包括接收表示从样品的质谱法获得的多个质谱的数据，根据与目标糖肽相关的数据表示表示多个质谱图中的每一个的评分数据，以及鉴定一个或多个完整的糖肽 所述样本至少部分地基于表示所述多个质谱图中的每一个的所述数据的评分。

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