公开(公告)号：US10479998B2

公开(公告)日：2019-11-19

申请号：US15838556

申请日：2017-12-12

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Maria T. Arevalo

IPC: C07K16/28 ,  C12N15/11 ,  C12N15/113

Abstract: The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of treating anthrax exposure with the same.

公开(公告)号：US20180112223A1

公开(公告)日：2018-04-26

申请号：US15838556

申请日：2017-12-12

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Maria T. Arevalo

IPC: C12N15/113 ,  C07K16/28

CPC classification number: C12N15/1138 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/76 ,  C12N2310/14 ,  C12N2320/30

Abstract: The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of treating anthrax exposure with the same.

公开(公告)号：US20160145627A1

公开(公告)日：2016-05-26

申请号：US14898179

申请日：2014-06-12

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： Mingtao Zeng ,  Maria T. Arevalo

IPC: C12N15/113 ,  C07K16/28

CPC classification number: C12N15/1138 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/76 ,  C12N2310/14 ,  C12N2320/30

Abstract: The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of treating anthrax exposure with the same.

Abstract translation: 本发明包括阻断TEM8和/或CMG2细胞表面蛋白质和炭疽毒素之间的相互作用的siRNA和抗体以及用其处理炭疽暴露的方法。

公开(公告)号：US10370416B2

公开(公告)日：2019-08-06

申请号：US15446315

申请日：2017-03-01

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Maria T. Arevalo ,  Junwei Li

IPC: C07K14/005 ,  G01N33/50 ,  A61K39/07 ,  A61K39/12 ,  A61K39/00

Abstract: The present invention includes antigenic fusion proteins, nucleic acids encoding the fusion proteins and methods of making and using the same, wherein the fusion protein comprises three or more different influenza A ectodomains of Matrix Protein 2 (M2e); one or more stem regions of an influenza A hemagglutinin 2 (HA2) protein; and optionally an anthrax antigen, wherein the fusion protein is immunogenic across strains.

公开(公告)号：US09862951B2

公开(公告)日：2018-01-09

申请号：US14898179

申请日：2014-06-12

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Maria T. Arevalo

IPC: C12N15/113 ,  C07K16/28

CPC classification number: C12N15/1138 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/76 ,  C12N2310/14 ,  C12N2320/30

Abstract: The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of treating anthrax exposure with the same.

公开(公告)号：US20170253636A1

公开(公告)日：2017-09-07

申请号：US15446315

申请日：2017-03-01

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Maria T. Arevalo ,  Junwei Li

IPC: C07K14/005 ,  G01N33/50 ,  A61K39/145

CPC classification number: C07K14/005 ,  A61K39/07 ,  A61K39/12 ,  A61K2039/543 ,  A61K2039/572 ,  A61K2039/575 ,  A61K2039/70 ,  C07K2319/40 ,  C07K2319/55 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16162 ,  G01N33/5023 ,  G01N33/5088 ,  G01N2333/11 ,  G01N2333/32

Abstract: The present invention includes antigenic fusion proteins, nucleic acids encoding the fusion proteins and methods of making and using the same, wherein the fusion protein comprises three or more different influenza A ectodomains of Matrix Protein 2 (M2e); one or more stem regions of an influenza A hemagglutinin 2 (HA2) protein; and optionally an anthrax antigen, wherein the fusion protein is immunogenic across strains.