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    DE NOVO ANTIBODY DESIGN
    62.
    发明申请
    DE NOVO ANTIBODY DESIGN 审中-公开

    公开(公告)号：US20200168293A1

    公开(公告)日：2020-05-28

    申请号：US15781228

    申请日：2016-12-01

    Applicant: UCB Biopharma SPRL

    Inventor： Terence Seward Baker ,  Xiaofeng Liu ,  Jiye Shi ,  Richard David Taylor

    IPC: G16B20/30 ,  G16B15/00 ,  G06F30/20

    Abstract: Computer-implemented methods of designing an antibody that will bind to a target epitope are disclosed. In one arrangement, the method comprises identifying one or more hotspot residues that will each bind to a corresponding one of one or more hotspot sites on the target epitope. Candidate antibody structures are selected from a database such that characteristic atoms within the antibody structure and hotspot characteristic atoms can be superimposed computationally with an averaged spatial deviation less than a predetermined threshold. A designed antibody is generated by replacing matching residues with different residues such that a predicted affinity is increased.

    Single Linker FabFv Antibodies and Methods of Producing Same
    64.
    发明申请
    Single Linker FabFv Antibodies and Methods of Producing Same 审中-公开

    公开(公告)号：US20200055959A1

    公开(公告)日：2020-02-20

    申请号：US16573893

    申请日：2019-09-17

    Applicant: UCB Biopharma SPRL

    Inventor： Emma Dave ,  Sam Philip Heywood ,  David Paul Humphreys

    IPC: C07K16/46 ,  C07K16/18 ,  C07K16/28

    Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I):(Vxx)nVx-Cx-X-V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III):V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, nindependently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V1 and V2, in particular where a disulphide bond is present. The disclosure also extends to pharmaceutical formulation comprising the construct, DNA encoding the constructs and vectors comprising same. The disclosure further extends to a method of expressing the constructs, for example in a host cell and methods for formulating same as a pharmaceutical composition. The disclosure also relates to use of the constructs and formulations in treatment.

    HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION
    67.
    发明申请
    HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION 审中-公开

    公开(公告)号：US20190308965A1

    公开(公告)日：2019-10-10

    申请号：US16438348

    申请日：2019-06-11

    Applicant: UCB Biopharma SPRL

    Inventor： Wolfgang WRASIDLO ,  Emily M. Stocking

    IPC: C07D417/12 ,  C07D413/12 ,  C07D417/14 ,  C07D403/12

    Abstract: The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.

    Antibodies
    69.
    发明授权
    Antibodies 有权

    公开(公告)号：US10421814B2

    公开(公告)日：2019-09-24

    申请号：US15883130

    申请日：2018-01-30

    Applicant: UCB BIOPHARMA SPRL

    Inventor： Graham Craggs ,  Karine Jeannine Madeleine Herve ,  Diane Marshall

    IPC: C07K16/28 ,  C07K16/00 ,  A61K38/18 ,  A61K39/00

    Abstract: The present invention relates to an anti-CSF-1R antibody and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The present invention also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment.

    Process for reconstitution of a solid form of a pharmaceutical composition
    70.
    发明授权
    Process for reconstitution of a solid form of a pharmaceutical composition 有权

    公开(公告)号：US10376467B2

    公开(公告)日：2019-08-13

    申请号：US15112046

    申请日：2015-01-20

    Applicant: UCB BIOPHARMA SPRL ,  EVEON

    Inventor： Xavier Payet-Burin

    IPC: A61K9/19 ,  A61K9/00 ,  A61K47/60

    Abstract: The invention relates to a process for reconstitution of a solid form of a pharmaceutical composition, comprising the following successive steps: (i) providing the solid form of the pharmaceutical composition in a sealed container, the pressure within the container being an initial pressure (pi,) comprised between 0.5 Pa and 1.2×105 Pa; (ii) at a first time point (t0) introducing the solvent into said sealed container and maintaining the resulting pressure (pr) within the container during a controlled time Δt1; and (iii) at a second time point (t2) increasing the pressure within the container to a controlled pressure (p2) higher than said resulting pressure (pr) until complete reconstitution.

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