公开(公告)号：US20160200820A1

公开(公告)日：2016-07-14

申请号：US14914673

申请日：2014-08-26

Applicant: UCB BIOPHARMA SPRL

Inventor： Diane MARSHALL

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C12N15/113

CPC classification number: C07K16/2866 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1138 ,  C12N2320/30

Abstract: The present invention relates generally to methods of treating fibrotic disease and more specifically to an inhibitor of CSF-1R activity for the treatment and/or prophylaxis of fibrotic disease, wherein the inhibitor comprises a small chemical entity (NCE), a nucleic acid or an antibody or functionally active fragment or derivative thereof. The present invention further pertains to the use of an inhibitor of CSF-1R activity, for the manufacture of a medicament for the treatment and/or prophylaxis of fibrotic disease.

Abstract translation: 本发明一般涉及治疗纤维化疾病的方法，更具体地涉及用于治疗和/或预防纤维化疾病的CSF-1R活性抑制剂，其中所述抑制剂包括小化学实体（NCE），核酸或 抗体或其功能活性片段或衍生物。 本发明还涉及CSF-1R活性抑制剂在制备用于治疗和/或预防纤维化疾病的药物中的应用。

公开(公告)号：US20190330321A1

公开(公告)日：2019-10-31

申请号：US16307444

申请日：2017-06-07

Applicant: UCB BIOPHARMA SPRL

Inventor： Helene BON ,  Joanne Elizabeth COMPSON ,  Kate Louise DIXON ,  Carl Brendan DOYLE ,  Mark ELLIS ,  Maria Margarida GOUVEIA SANCHO ,  Raymond Anthony JUPP ,  Lara KEVORKIAN ,  Daniel John LIGHTWOOD ,  Diane MARSHALL ,  Andrew Charles PAYNE ,  Joseph Michael David RASTRICK ,  Monika-Sarah SCHULZE ,  Alison TURNER ,  Kerry Louise TYSON

IPC: C07K16/22 ,  A61K9/00 ,  A61P11/00

Abstract: The present disclosure relates to TGF-beta antibodies and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The disclosure also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment of various diseases including fibrosis.