公开(公告)号：US20190330321A1

公开(公告)日：2019-10-31

申请号：US16307444

申请日：2017-06-07

Applicant: UCB BIOPHARMA SPRL

Inventor： Helene BON ,  Joanne Elizabeth COMPSON ,  Kate Louise DIXON ,  Carl Brendan DOYLE ,  Mark ELLIS ,  Maria Margarida GOUVEIA SANCHO ,  Raymond Anthony JUPP ,  Lara KEVORKIAN ,  Daniel John LIGHTWOOD ,  Diane MARSHALL ,  Andrew Charles PAYNE ,  Joseph Michael David RASTRICK ,  Monika-Sarah SCHULZE ,  Alison TURNER ,  Kerry Louise TYSON

IPC: C07K16/22 ,  A61K9/00 ,  A61P11/00

Abstract: The present disclosure relates to TGF-beta antibodies and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The disclosure also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment of various diseases including fibrosis.