公开(公告)号：US20190270811A1

公开(公告)日：2019-09-05

申请号：US16299407

申请日：2019-03-12

Applicant: UCB BIOPHARMA SPRL

Inventor： Paul Alan ATHERFOLD ,  Thomas Allen CESKA ,  Helene Margaret FINNEY ,  Lara KEVORKIAN ,  Kaushik SARKAR ,  Bryan John SMITH ,  Kerry Louise TYSON

IPC: C07K16/28 ,  A61K47/68 ,  A61K47/60

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

公开(公告)号：US20220162311A1

公开(公告)日：2022-05-26

申请号：US17643506

申请日：2021-12-09

Applicant: UCB BIOPHARMA SPRL

Inventor： Paul Alan ATHERFOLD ,  Thomas Allen CESKA ,  Helene Margaret FINNEY ,  Lara KEVORKIAN ,  Kaushik SARKAR ,  Bryan John SMITH ,  Kerry Louise TYSON

IPC: C07K16/28 ,  A61K47/68 ,  A61K47/60

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

公开(公告)号：US20190330321A1

公开(公告)日：2019-10-31

申请号：US16307444

申请日：2017-06-07

Applicant: UCB BIOPHARMA SPRL

Inventor： Helene BON ,  Joanne Elizabeth COMPSON ,  Kate Louise DIXON ,  Carl Brendan DOYLE ,  Mark ELLIS ,  Maria Margarida GOUVEIA SANCHO ,  Raymond Anthony JUPP ,  Lara KEVORKIAN ,  Daniel John LIGHTWOOD ,  Diane MARSHALL ,  Andrew Charles PAYNE ,  Joseph Michael David RASTRICK ,  Monika-Sarah SCHULZE ,  Alison TURNER ,  Kerry Louise TYSON

IPC: C07K16/22 ,  A61K9/00 ,  A61P11/00

Abstract: The present disclosure relates to TGF-beta antibodies and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The disclosure also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment of various diseases including fibrosis.

公开(公告)号：US20160264668A1

公开(公告)日：2016-09-15

申请号：US15036209

申请日：2014-11-12

Applicant: UCB BIOPHARMA SPRL

Inventor： Paul Alan ATHERFOLD ,  Thomas Allen CESKA ,  Helene Margaret FINNEY ,  Lara KEVORKIAN ,  Kaushik SARKAR ,  Bryan John SMITH ,  Kerry Louise TYSON

IPC: C07K16/28 ,  A61K47/48

CPC classification number: C07K16/283 ,  A61K47/60 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/624 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.

Abstract translation: 本公开涉及对FcRn特异性的抗体，包含其的制剂，治疗中的每一种的使用，用于表达和任选配制所述抗体的方法，编码抗体的DNA和包含所述DNA的宿主。