公开(公告)号：US20060122378A1

公开(公告)日：2006-06-08

申请号：US11336748

申请日：2006-01-19

Applicant: Brian Perry ,  Paul Nelson ,  Te-Tuan Yang ,  Thomas Smith

Inventor： Brian Perry ,  Paul Nelson ,  Te-Tuan Yang ,  Thomas Smith

IPC: C07K1/10

CPC classification number: B01D15/3828 ,  B01J20/3265 ,  B01J45/00 ,  C07K1/22 ,  C07K14/43595 ,  C07K2319/21 ,  C12N9/003 ,  G01N30/02 ,  B01D15/3804

Abstract: Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2+ and a coordination number of 6. A method for synthesizing the metal ion-CM-Asp complex is also described. Further, the metal ion-CM-Asp complex can be used for screening protein function.

Abstract translation: 聚氨基酸标记的重组蛋白的纯化已通过使用与氧化状态为2 +和/或配位数6的第三嵌段过渡金属络合的羧甲基化天冬氨酸配体得到改善。 还描述了合成金属离子-CM-Asp络合物的方法。 此外，金属离子-CM-Asp复合物可用于筛选蛋白质功能。

公开(公告)号：US07041819B2

公开(公告)日：2006-05-09

申请号：US09939514

申请日：2001-08-24

Applicant: Jonathan L. Sessler ,  Manuel Marquez ,  Pavel Anzenbacher, Jr. ,  James A. Shriver

Inventor： Jonathan L. Sessler ,  Manuel Marquez ,  Pavel Anzenbacher, Jr. ,  James A. Shriver

IPC: C07D487/22

CPC classification number: C07F17/02 ,  B01J20/22 ,  B01J20/281 ,  B01J20/286 ,  B01J20/288 ,  B01J45/00 ,  B01J2220/54 ,  C07D487/22 ,  C07D495/22 ,  C07D498/22 ,  G01N30/02 ,  G01N30/482 ,  G01N30/88 ,  G01N2030/484 ,  G21F9/06 ,  G21F9/12 ,  B01D15/26

Abstract: The present invention provides halogenated calixpyrrole, calixpyridinopyrrole, and calixpyridine macrocycles having 4–12 pyrrolic rings with greater stability, enhanced anion and neutral molecule binding affinity, and different binding selectivites as compared to their non-halogenated congeners as judged from 1H NMR, 19F NMR and fluorescence emission spectroscopic analyses.

Abstract translation: 本发明提供了与其非卤化同源物相比，具有4-12个具有更大稳定性，增强的阴离子和中性分子结合亲和力的吡咯环的卤化杯芳吡咯，杯状吡啶并吡咯大环化合物， 1 H NMR，19 F NMR和荧光发射光谱分析。

公开(公告)号：US07008601B2

公开(公告)日：2006-03-07

申请号：US10405391

申请日：2003-04-02

Applicant: Edward Rosenberg ,  Robert J. Fischer

Inventor： Edward Rosenberg ,  Robert J. Fischer

IPC: C22B15/00 ,  C22B61/00

CPC classification number: B01J20/3242 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/328 ,  B01J45/00 ,  C22B3/24 ,  C22B15/0063 ,  C22B15/0089 ,  Y02P10/234 ,  Y02P10/236 ,  Y10T428/2995 ,  Y10T428/31663

Abstract: A silica-polyamine based extraction material removes selected transition metal ions from solution in the presence of iron ions. The silica-polyamine base is a reaction product of a polyamine and a covalently anchored trifunctional hydrocarbylsilyl that yields non-crosslinked amino groups to which pyridine function group is attached. The extraction material is particularly useful in selectively removing copper from low concentration, low pH leach solutions separating copper from ferric iron or chloride ions. The product is a durable, high capacity extraction material that selectively captures copper at high flow rates and releases that copper into highly concentrated solutions.

公开(公告)号：US20060027501A1

公开(公告)日：2006-02-09

申请号：US11244603

申请日：2005-10-06

Applicant: Lars Andersson ,  Ulf Tedebark ,  Tesfai Gebru ,  Andreas Axen ,  Jean-Luc Maloisel

Inventor： Lars Andersson ,  Ulf Tedebark ,  Tesfai Gebru ,  Andreas Axen ,  Jean-Luc Maloisel

IPC: B01D15/08

CPC classification number: B01J45/00 ,  B01D15/3828 ,  B01J20/286 ,  B01J20/3251 ,  B01J20/3265 ,  C07C323/58 ,  C07D333/36

Abstract: The present invention relates to a method of generating at least one polydentate metal chelating affinity ligand, which method comprises the steps of (a) providing at least one cyclic scaffold comprising a carbonyl, an adjacent sulphur and a nucleophile; (b) providing at least one polydentate metal chelating affinity ligand arm, optionally in a form wherein the metal chelating functionalities are protected, on each scaffold by derivatisation of the nucleophile of said scaffolds, while retaining the cyclic structure of the scaffold; (c) ring-opening at the bond between the carbonyl and the sulphur of the derivatised scaffold by adding a reagent that adds one or more metal chelating affinity ligand arms to the scaffold; and, if required, (d) deprotecting the functionalities of the ligand arm(s) provided in step (b). In the most preferred embodiment of the method, steps (c) and (d) are performed simultaneously as one single step.

Abstract translation: 本发明涉及产生至少一种多齿金属螯合亲和配体的方法，该方法包括以下步骤：（a）提供至少一种包含羰基，相邻硫和亲核试剂的环状支架; （b）在保留支架的环状结构的同时，通过衍生所述支架的亲核试剂，在每个支架上提供至少一种多金属金属螯合亲和配体臂，任选地以金属螯合官能团的形式被保护; （c）通过加入一种将一种或多种金属螯合亲和配体臂添加到支架中的试剂，在衍生化支架的羰基和硫之间的键上开环; 如果需要，（d）使步骤（b）中提供的配体臂的功能脱保护。 在该方法的最优选实施方案中，步骤（c）和（d）同时作为一个步骤进行。

公开(公告)号：US20060014722A1

公开(公告)日：2006-01-19

申请号：US10517582

申请日：2003-06-11

Applicant: Andree Gadelle

Inventor： Andree Gadelle

IPC: A61K31/728 ,  C08B37/16

CPC classification number: C08B37/0015 ,  A61K31/724 ,  B01J45/00 ,  C02F1/42 ,  C02F2101/20 ,  C02F2101/22 ,  C08B37/0012 ,  C08G18/3218 ,  C08G18/6484 ,  C08G18/71 ,  C08G18/73

Abstract: The invention relates to per(3,6-anhydro)cyclodextrin derivatives containing in C2 at least one carbamate group, polymers thereof, their preparation and their use for separating contaminating anions such as the anions CrO42−, Cr2O72− or MnO42−.

Abstract translation: 本发明涉及含有C 2至少一个氨基甲酸酯基团的每（3,6-脱水）环糊精衍生物，其聚合物，其制备及其用于分离污染性阴离子如阴离子CrO _{2 ，2 2 2或 / SUB> ^{2 - 。}}

公开(公告)号：US20050272116A1

公开(公告)日：2005-12-08

申请号：US10861660

申请日：2004-06-04

Applicant: Michael Ellison ,  Albert Abbott ,  Darren Baker

Inventor： Michael Ellison ,  Albert Abbott ,  Darren Baker

IPC: B01J45/00 ,  C07K1/10 ,  C07K1/22 ,  C12P21/06

CPC classification number: B01J45/00 ,  C07K1/22 ,  Y02P20/582

Abstract: A polymer substrate for recombinant protein purification is provided. A process for purifying recombinant proteins is also provided. In general, the present invention is directed to a chelating composition which may be used in a self-supported purification medium for recombinant protein purification. In another embodiment, a process for removal of transition metals from environmental waste is also provided.

Abstract translation: 提供了用于重组蛋白纯化的聚合物底物。 还提供了一种纯化重组蛋白的方法。 通常，本发明涉及可用于重组蛋白纯化的自支撑纯化介质中的螯合组合物。 在另一个实施方案中，还提供了从环境废物中除去过渡金属的方法。

公开(公告)号：US20050209444A1

公开(公告)日：2005-09-22

申请号：US11032281

申请日：2005-01-10

Applicant: Tonny Johnson ,  Rebecca Godat ,  Laurie Engel

Inventor： Tonny Johnson ,  Rebecca Godat ,  Laurie Engel

IPC: B01D15/38 ,  B01J45/00 ,  C07K1/14 ,  C07K1/22 ,  C07K1/16

CPC classification number: B01J45/00 ,  C07K1/22

Abstract: Disclosed are methods of separating a target molecule from a non-target molecule using zinc- or cobalt-charged solid supports.

公开(公告)号：US06867295B2

公开(公告)日：2005-03-15

申请号：US09949010

申请日：2001-09-07

Applicant: L. Andy Woodruff ,  Andrei V. Bordunov ,  Christopher A. Pohl

Inventor： L. Andy Woodruff ,  Andrei V. Bordunov ,  Christopher A. Pohl

IPC: G01N30/02 ,  B01D15/08 ,  B01J20/281 ,  B01J20/285 ,  B01J41/14 ,  B01J45/00 ,  C08J5/20 ,  G01N30/26 ,  G01N30/34 ,  G01N30/64 ,  G01N30/88 ,  C08B37/16

CPC classification number: B01J45/00 ,  B01J41/14

Abstract: One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween.In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.

Abstract translation: 本发明的一个实施方案包括通过使自由基活化条件下的不饱和碳与衍生的离子结合穴状物侧基的碳部分与支持底物反应而形成的离子交换组合物，在其间形成共价键。在另一个实施方案中，穴状离子交换组合物是 通过共价键合不饱和碳与从不饱和碳衍生的衍生化离子结合穴状结构的碳部分与自由基激活条件下从载体底物侧基形成共价键的碳部分共价键合。

公开(公告)号：US20050014654A1

公开(公告)日：2005-01-20

申请号：US10623044

申请日：2003-07-18

Applicant: Qi Qu ,  Paul Javora ,  Joel Boles ,  Sandra Berry

Inventor： Qi Qu ,  Paul Javora ,  Joel Boles ,  Sandra Berry

IPC: E21B21/06 ,  E21B43/00

CPC classification number: E21B21/068 ,  B01D19/04 ,  B01J45/00 ,  Y10S210/912

Abstract: A method of reclaiming a well completion brine solution by using an organic chelant that is capable of discriminating between (i) iron and non-zinc heavy metals; and (ii) calcium and zinc. The chelant contains a functional group selected from the group —CO2H or —PO(OH)R20 or a salt or ester thereof, —C(O)—, —OE, —SE, —N═C(R2)R3, EO—N═C(R2)R3, —N(R2)R3, and —N(C(O)R1)R2 group optionally substituted with a —COOH or —PO(OH)R20 or a salt or ester thereof, —SE or —OE group, wherein R2 and R3 are independently selected from E or forms, with nitrogen, phosphorous, oxygen or sulfur, a heterocyclic ring; E is R1 or —H; R1 is a C1-C30 alkyl or aralkyl group or a derivative thereof and R20 is —OH or R1.

Abstract translation: 通过使用能够区分（i）铁和非锌重金属的有机螯合剂回收完井盐水溶液的方法; 和（ii）钙和锌。 螯合剂含有选自-CO 2 H或-PO（OH）R 20的官能团或其盐或酯，-C（O） - ， - OE，-SE，-N = C（R 2） ）R 3，EO-N = C（R 2）R 3，-N（R 2）R 3和-N（C（O）R 1）R 任选被-COOH或-PO（OH）R 20或其盐或酯取代的基团，-SE或-OE基团，其中R 2和R 3独立地选自E或形式，与 氮，磷，氧或硫，杂环; E是R 1或-H; R 1是C 1 -C 30烷基或芳烷基或其衍生物，R 20是-OH或R 1。

公开(公告)号：US20040178385A1

公开(公告)日：2004-09-16

申请号：US10486829

申请日：2004-02-20

Inventor： Isabelle Bispo ,  Slobodan Milonjic

IPC: C02F005/02 ,  C09K003/00 ,  B32B027/00

CPC classification number: G21F9/12 ,  B01J39/17 ,  B01J45/00 ,  Y10T428/31721

Abstract: Process for the preparation of a composite solid material which fixes inorganic contaminants, based on metal hexacyanoferrate, comprising a solid support coated with a film of an anion-exchange polymer to which is fixed an insoluble metal hexacyanoferrate forming a thin layer, said process essentially comprising at least one step in which said solid support is brought into contact with at least one liquid reactant and at least one step in which washing is carried out with a washing liquid, characterized in that all of the steps of the process are carried out continuously in one and the same receptacle, such as a column, in which the support forms a fluidized bed, the fluidization of which is provided by said at least one reactant or washing liquid.

Abstract translation: 一种复合固体材料的制备方法，该复合固体材料固定了基于金属六氰基铁酸盐的无机污染物，其包含涂覆有阴离子交换聚合物膜的固体载体，固定了形成薄层的不溶性金属六氰基铁酸盐，所述方法基本上包括 至少一个步骤，其中所述固体支持物与至少一种液体反应物接触，以及至少一个步骤，其中用洗涤液进行洗涤，其特征在于，所述方法的所有步骤在 一个和相同的容器，例如塔，其中载体形成流化床，其流化由所述至少一种反应物或洗涤液体提供。